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Article: Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause
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TitleEffects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause
 
AuthorsSze, SCW1
Cheung, HP1
Ng, TB3
Zhang, ZJ1
Wong, KL1
Wong, HK1
Hu, YM1
Yow, CMN2
Tong, Y1
 
KeywordsAnimal experiment
Chinese medicine
Cholesterol blood level
Down regulation
Lipid blood level
 
Issue Date2011
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
 
CitationChinese Medicine, 2011, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-8546-6-40
 
AbstractBackground: The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.Methods: Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.Results: The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor. © 2011 Sze et al; licensee BioMed Central Ltd.
 
ISSN1749-8546
2013 Impact Factor: 2.343
2013 SCImago Journal Rankings: 0.810
 
DOIhttp://dx.doi.org/10.1186/1749-8546-6-40
 
PubMed Central IDPMC3231803
 
ISI Accession Number IDWOS:000208722100040
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSze, SCW
 
dc.contributor.authorCheung, HP
 
dc.contributor.authorNg, TB
 
dc.contributor.authorZhang, ZJ
 
dc.contributor.authorWong, KL
 
dc.contributor.authorWong, HK
 
dc.contributor.authorHu, YM
 
dc.contributor.authorYow, CMN
 
dc.contributor.authorTong, Y
 
dc.date.accessioned2012-08-16T07:38:47Z
 
dc.date.available2012-08-16T07:38:47Z
 
dc.date.issued2011
 
dc.description.abstractBackground: The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.Methods: Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.Results: The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor. © 2011 Sze et al; licensee BioMed Central Ltd.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationChinese Medicine, 2011, v. 6 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-8546-6-40
 
dc.identifier.doihttp://dx.doi.org/10.1186/1749-8546-6-40
 
dc.identifier.hkuros205010
 
dc.identifier.isiWOS:000208722100040
 
dc.identifier.issn1749-8546
2013 Impact Factor: 2.343
2013 SCImago Journal Rankings: 0.810
 
dc.identifier.pmcidPMC3231803
 
dc.identifier.pmid22047073
 
dc.identifier.scopuseid_2-s2.0-80055103742
 
dc.identifier.urihttp://hdl.handle.net/10722/161241
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofChinese Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectAnimal experiment
 
dc.subjectChinese medicine
 
dc.subjectCholesterol blood level
 
dc.subjectDown regulation
 
dc.subjectLipid blood level
 
dc.titleEffects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause
 
dc.typeArticle
 
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<contributor.author>Zhang, ZJ</contributor.author>
<contributor.author>Wong, KL</contributor.author>
<contributor.author>Wong, HK</contributor.author>
<contributor.author>Hu, YM</contributor.author>
<contributor.author>Yow, CMN</contributor.author>
<contributor.author>Tong, Y</contributor.author>
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<description.abstract>Background: The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.Methods: Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.Results: The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor. &#169; 2011 Sze et al; licensee BioMed Central Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Hong Kong Polytechnic University
  3. Chinese University of Hong Kong