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Article: Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause

TitleEffects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause
Authors
KeywordsAnimal experiment
Chinese medicine
Cholesterol blood level
Down regulation
Lipid blood level
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/home
Citation
Chinese Medicine, 2011, v. 6 How to Cite?
AbstractBackground: The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.Methods: Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.Results: The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor. © 2011 Sze et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/161241
ISSN
2014 Impact Factor: 1.490
2014 SCImago Journal Rankings: 0.693
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorCheung, HPen_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorWong, KLen_HK
dc.contributor.authorWong, HKen_HK
dc.contributor.authorHu, YMen_HK
dc.contributor.authorYow, CMNen_HK
dc.contributor.authorTong, Yen_HK
dc.date.accessioned2012-08-16T07:38:47Z-
dc.date.available2012-08-16T07:38:47Z-
dc.date.issued2011en_HK
dc.identifier.citationChinese Medicine, 2011, v. 6en_HK
dc.identifier.issn1749-8546en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161241-
dc.description.abstractBackground: The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile in a menopausal rat model.Methods: Twenty-month-old female Sprague Dawley rats were treated with EXD and its constituent fractions. Premarin was administered for comparison. After eight weeks of treatment, rats were sacrificed and the serum levels of total cholesterol, triglyceride, high-density-lipoprotein cholesterol and low-density-lipoprotein cholesterol were determined. The hepatic protein levels of 3-hydroxy-3-methyl-glutaryl-CoA reductase and low-density-lipoprotein receptor were assessed with Western blot.Results: The serum levels of total cholesterol and low-density-lipoprotein cholesterol were significantly lower in the EXD-treated group than in the constituent fractions of EXD or premarin groups. However, the serum levels of triglyceride and high-density-lipoprotein cholesterol were not significantly different from the control groups. Results from Western blot suggest that EXD significantly down-regulated the protein level of 3-hydroxy-3-methyl-glutaryl-CoA reductase and up-regulated low-density-lipoprotein receptor. Conclusion EXD improves serum lipid profile in a menopausal rat model through the suppression of the serum levels of total cholesterol and low-density-lipoprotein cholesterol, possibly through the down-regulation of the 3-hydroxy-3-methyl-glutaryl-CoA and up-regulation of the low-density-lipoprotein receptor. © 2011 Sze et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cmjournal.org/homeen_HK
dc.relation.ispartofChinese Medicineen_HK
dc.rightsChinese Medicine. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnimal experiment-
dc.subjectChinese medicine-
dc.subjectCholesterol blood level-
dc.subjectDown regulation-
dc.subjectLipid blood level-
dc.titleEffects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopauseen_HK
dc.typeArticleen_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1749-8546-6-40en_HK
dc.identifier.pmid22047073-
dc.identifier.pmcidPMC3231803-
dc.identifier.scopuseid_2-s2.0-80055103742en_HK
dc.identifier.hkuros205010en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055103742&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.isiWOS:000208722100040-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridCheung, HP=37033470100en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridWong, KL=47861480700en_HK
dc.identifier.scopusauthoridWong, HK=36920239700en_HK
dc.identifier.scopusauthoridHu, YM=7407116890en_HK
dc.identifier.scopusauthoridYow, CMN=6602535418en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK

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