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Article: Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China
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TitleEvidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China
 
AuthorsLessler, J7
Riley, S6
Read, JM2
Wang, S4
Zhu, H5 3
Smith, GJD1
Guan, Y5 3
Jiang, CQ4
Cummings, DAT7
 
Issue Date2012
 
PublisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
 
CitationPlos Pathogens, 2012, v. 8 n. 7, p. 26 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.ppat.1002802
 
AbstractA key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life. © 2012 Lessler et al.
 
ISSN1553-7366
 
DOIhttp://dx.doi.org/10.1371/journal.ppat.1002802
 
PubMed Central IDPMC3400560
 
ISI Accession Number IDWOS:000306837700026
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLessler, J
 
dc.contributor.authorRiley, S
 
dc.contributor.authorRead, JM
 
dc.contributor.authorWang, S
 
dc.contributor.authorZhu, H
 
dc.contributor.authorSmith, GJD
 
dc.contributor.authorGuan, Y
 
dc.contributor.authorJiang, CQ
 
dc.contributor.authorCummings, DAT
 
dc.date.accessioned2012-08-16T06:39:34Z
 
dc.date.available2012-08-16T06:39:34Z
 
dc.date.issued2012
 
dc.description.abstractA key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life. © 2012 Lessler et al.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPlos Pathogens, 2012, v. 8 n. 7, p. 26 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.ppat.1002802
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.ppat.1002802
 
dc.identifier.epage26
 
dc.identifier.hkuros203143
 
dc.identifier.isiWOS:000306837700026
 
dc.identifier.issn1553-7366
 
dc.identifier.issue7
 
dc.identifier.pmcidPMC3400560
 
dc.identifier.pmid22829765
 
dc.identifier.scopuseid_2-s2.0-84864612944
 
dc.identifier.spage26
 
dc.identifier.urihttp://hdl.handle.net/10722/161148
 
dc.identifier.volume8
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS Pathogens
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleEvidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China
 
dc.typeArticle
 
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<description.abstract>A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual&apos;s first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (&lt;1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more &apos;senior&apos; strains encountered earlier in life. &#169; 2012 Lessler et al.</description.abstract>
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Author Affiliations
  1. Duke-NUS Graduate Medical School Singapore
  2. University of Liverpool
  3. The University of Hong Kong
  4. Guangzhou No. 12 Hospital
  5. Shantou University, Medical College (SUMC)
  6. Imperial College London
  7. Johns Hopkins Bloomberg School of Public Health