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Article: Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China

TitleEvidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
Citation
Plos Pathogens, 2012, v. 8 n. 7, p. 26 How to Cite?
AbstractA key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life. © 2012 Lessler et al.
Persistent Identifierhttp://hdl.handle.net/10722/161148
ISSN
2015 Impact Factor: 7.003
2015 SCImago Journal Rankings: 5.185
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLessler, Jen_HK
dc.contributor.authorRiley, Sen_HK
dc.contributor.authorRead, JMen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorSmith, GJDen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorCummings, DATen_HK
dc.date.accessioned2012-08-16T06:39:34Z-
dc.date.available2012-08-16T06:39:34Z-
dc.date.issued2012en_HK
dc.identifier.citationPlos Pathogens, 2012, v. 8 n. 7, p. 26en_HK
dc.identifier.issn1553-7366en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161148-
dc.description.abstractA key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains - from the same sera - in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life. © 2012 Lessler et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374en_HK
dc.relation.ispartofPLoS Pathogensen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEvidence for antigenic seniority in influenza A (H3N2) antibody responses in southern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailRiley, S: steven.riley@hku.hken_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityRiley, S=rp00511en_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.ppat.1002802en_HK
dc.identifier.pmid22829765-
dc.identifier.pmcidPMC3400560-
dc.identifier.scopuseid_2-s2.0-84864612944en_HK
dc.identifier.hkuros203143en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864612944&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue7en_HK
dc.identifier.spage26en_HK
dc.identifier.epage26en_HK
dc.identifier.isiWOS:000306837700026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLessler, J=22951309100en_HK
dc.identifier.scopusauthoridRiley, S=7102619416en_HK
dc.identifier.scopusauthoridRead, JM=36761595400en_HK
dc.identifier.scopusauthoridWang, S=51261625200en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridSmith, GJD=24375486800en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridCummings, DAT=9842706300en_HK

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