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Article: The recombinant origin of emerging human norovirus GII.4/2008: Intra-genotypic exchange of the capsid P2 domain

TitleThe recombinant origin of emerging human norovirus GII.4/2008: Intra-genotypic exchange of the capsid P2 domain
Authors
Issue Date2012
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 2012, v. 93 n. 4, p. 817-822 How to Cite?
AbstractGII.4 noroviruses are a major cause of acute gastroenteritis in humans. A new variant of GII.4, the 2008 variant, has recently increased its prevalence on a global scale. A previous study of this variant in Japan suggested that it might be of recombinant origin, with a breakpoint at the ORF1-ORF2 junction. Here, examination of the evolutionary origin of the 2008 variant based on a larger sample of worldwide GII.4 norovirus sequences revealed a more complex pattern of recombination between the 2006a- and 2006b-like variants of genotype GII.4, involving the P2 antigenic domain. Double (termed '2008i') and triple (termed '2008ii') recombinant forms of 2008 variants were identified. This study highlights the possible importance of intra-genotypic recombination over antigenic regions in driving norovirus evolution, and is suggestive of a process analogous to the antigenic shift of influenza A virus by reassortment. © 2012 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/161147
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorSmith, DKen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorHolmes, ECen_HK
dc.contributor.authorPybus, OGen_HK
dc.date.accessioned2012-08-16T06:39:33Z-
dc.date.available2012-08-16T06:39:33Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of General Virology, 2012, v. 93 n. 4, p. 817-822en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/161147-
dc.description.abstractGII.4 noroviruses are a major cause of acute gastroenteritis in humans. A new variant of GII.4, the 2008 variant, has recently increased its prevalence on a global scale. A previous study of this variant in Japan suggested that it might be of recombinant origin, with a breakpoint at the ORF1-ORF2 junction. Here, examination of the evolutionary origin of the 2008 variant based on a larger sample of worldwide GII.4 norovirus sequences revealed a more complex pattern of recombination between the 2006a- and 2006b-like variants of genotype GII.4, involving the P2 antigenic domain. Double (termed '2008i') and triple (termed '2008ii') recombinant forms of 2008 variants were identified. This study highlights the possible importance of intra-genotypic recombination over antigenic regions in driving norovirus evolution, and is suggestive of a process analogous to the antigenic shift of influenza A virus by reassortment. © 2012 SGM.en_HK
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.rightsJournal of General Virology. Copyright © Society for General Microbiology.-
dc.subject.meshCaliciviridae Infections - virology-
dc.subject.meshCapsid Proteins - genetics-
dc.subject.meshCommunicable Diseases, Emerging - virology-
dc.subject.meshGastroenteritis - virology-
dc.subject.meshNorovirus - genetics-
dc.titleThe recombinant origin of emerging human norovirus GII.4/2008: Intra-genotypic exchange of the capsid P2 domainen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1099/vir.0.039057-0en_HK
dc.identifier.pmid22238233-
dc.identifier.scopuseid_2-s2.0-84863275705en_HK
dc.identifier.hkuros203142en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863275705&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume93en_HK
dc.identifier.issue4en_HK
dc.identifier.spage817en_HK
dc.identifier.epage822en_HK
dc.identifier.isiWOS:000303074500016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridSmith, DK=7410351143en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridHolmes, EC=35433598300en_HK
dc.identifier.scopusauthoridPybus, OG=6701390795en_HK

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