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Article: Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern China

TitleEstablishment and lineage replacement of h6 influenza viruses in domestic ducks in southern China
Authors
Issue Date2012
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2012, v. 86 n. 11, p. 6075-6083 How to Cite?
Abstract
Domestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs. © 2012, American Society for Microbiology.
Persistent Identifierhttp://hdl.handle.net/10722/161145
ISSN
2013 Impact Factor: 4.648
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Shantou University, Medical College (SUMC)
  3. St. Jude Children Research Hospital
DC FieldValueLanguage
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorZhu, Hen_HK
dc.contributor.authorFan, Xen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorHong, Wen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorSmith, DKen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorWebby, RJen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2012-08-16T06:39:32Z-
dc.date.available2012-08-16T06:39:32Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Virology, 2012, v. 86 n. 11, p. 6075-6083en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/161145-
dc.description.abstractDomestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs. © 2012, American Society for Microbiology.en_HK
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2012, v. 86 n. 11, p. 6075-6083]-
dc.subject.meshAntigens, Viral - analysis-
dc.subject.meshChina - epidemiology-
dc.subject.meshInfluenza A virus - classification - genetics - immunology - isolation and purification-
dc.subject.meshInfluenza in Birds - epidemiology - virology-
dc.subject.meshDucks-
dc.titleEstablishment and lineage replacement of h6 influenza viruses in domestic ducks in southern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailZhu, H: zhuhch@hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityZhu, H=rp01535en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.06389-11en_HK
dc.identifier.pmid22438558-
dc.identifier.pmcidPMC3372190-
dc.identifier.scopuseid_2-s2.0-84863603266en_HK
dc.identifier.hkuros203139en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863603266&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume86en_HK
dc.identifier.issue11en_HK
dc.identifier.spage6075en_HK
dc.identifier.epage6083en_HK
dc.identifier.eissn1098-5514-
dc.identifier.isiWOS:000304229300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, K=44961130600en_HK
dc.identifier.scopusauthoridZhu, H=25724029300en_HK
dc.identifier.scopusauthoridFan, X=55272437100en_HK
dc.identifier.scopusauthoridWang, J=55142467100en_HK
dc.identifier.scopusauthoridCheung, CL=34975244700en_HK
dc.identifier.scopusauthoridDuan, L=55303068800en_HK
dc.identifier.scopusauthoridHong, W=55143833500en_HK
dc.identifier.scopusauthoridLiu, Y=55303418100en_HK
dc.identifier.scopusauthoridLi, L=44961381600en_HK
dc.identifier.scopusauthoridSmith, DK=36464390700en_HK
dc.identifier.scopusauthoridChen, H=55303920600en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridWebby, RJ=35448064800en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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