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Article: Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern China
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TitleEstablishment and lineage replacement of h6 influenza viruses in domestic ducks in southern China
 
AuthorsHuang, K2 1
Zhu, H2 1
Fan, X1
Wang, J2 1
Cheung, CL1
Duan, L2 1
Hong, W2
Liu, Y1
Li, L1
Smith, DK2 1
Chen, H2 1
Webster, RG3
Webby, RJ3
Peiris, M1
Guan, Y2 1
 
Issue Date2012
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
CitationJournal Of Virology, 2012, v. 86 n. 11, p. 6075-6083 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.06389-11
 
AbstractDomestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs. © 2012, American Society for Microbiology.
 
ISSN0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
DOIhttp://dx.doi.org/10.1128/JVI.06389-11
 
PubMed Central IDPMC3372190
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHuang, K
 
dc.contributor.authorZhu, H
 
dc.contributor.authorFan, X
 
dc.contributor.authorWang, J
 
dc.contributor.authorCheung, CL
 
dc.contributor.authorDuan, L
 
dc.contributor.authorHong, W
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorLi, L
 
dc.contributor.authorSmith, DK
 
dc.contributor.authorChen, H
 
dc.contributor.authorWebster, RG
 
dc.contributor.authorWebby, RJ
 
dc.contributor.authorPeiris, M
 
dc.contributor.authorGuan, Y
 
dc.date.accessioned2012-08-16T06:39:32Z
 
dc.date.available2012-08-16T06:39:32Z
 
dc.date.issued2012
 
dc.description.abstractDomestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs. © 2012, American Society for Microbiology.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal Of Virology, 2012, v. 86 n. 11, p. 6075-6083 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.06389-11
 
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.06389-11
 
dc.identifier.eissn1098-5514
 
dc.identifier.epage6083
 
dc.identifier.hkuros203139
 
dc.identifier.issn0022-538X
2012 Impact Factor: 5.076
2012 SCImago Journal Rankings: 2.559
 
dc.identifier.issue11
 
dc.identifier.pmcidPMC3372190
 
dc.identifier.pmid22438558
 
dc.identifier.scopuseid_2-s2.0-84863603266
 
dc.identifier.spage6075
 
dc.identifier.urihttp://hdl.handle.net/10722/161145
 
dc.identifier.volume86
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Virology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.
 
dc.rightsCopyright © American Society for Microbiology, [Journal of Virology, 2012, v. 86 n. 11, p. 6075-6083]
 
dc.subject.meshAntigens, Viral - analysis
 
dc.subject.meshChina - epidemiology
 
dc.subject.meshInfluenza A virus - classification - genetics - immunology - isolation and purification
 
dc.subject.meshInfluenza in Birds - epidemiology - virology
 
dc.subject.meshDucks
 
dc.titleEstablishment and lineage replacement of h6 influenza viruses in domestic ducks in southern China
 
dc.typeArticle
 
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<description.abstract>Domestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs. &#169; 2012, American Society for Microbiology.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Shantou University, Medical College (SUMC)
  3. St. Jude Children Research Hospital