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Article: Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury

TitleTargeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury
Authors
KeywordsStroke
Cerebral ischemia-reperfusion injury
Reactive nitrogen species
Nitric oxide
Peroxynitrite
Issue Date2013
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2013, v. 34 n. 1, p. 67–77 How to Cite?
AbstractIschemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic therapy often companies with cerebral ischemia-reperfusion injury, which are mediated by free radicals. As an important component of free radicals, reactive nitrogen species (RNS), including nitric oxide (NO) and peroxynitrite (ONOO(-)), play important roles in the process of cerebral ischemia-reperfusion injury. Ischemia-reperfusion results in the production of nitric oxide (NO) and peroxynitrite (ONOO(-)) in ischemic brain, which trigger numerous molecular cascades and lead to disruption of the blood brain barrier and exacerbate brain damage. There are few therapeutic strategies available for saving ischemic brains and preventing the subsequent brain damage. Recent evidence suggests that RNS could be a therapeutic target for the treatment of cerebral ischemia-reperfusion injury. Herein, we reviewed the recent progress regarding the roles of RNS in the process of cerebral ischemic-reperfusion injury and discussed the potentials of drug development that target NO and ONOO(-) to treat ischemic stroke. We conclude that modulation for RNS level could be an important therapeutic strategy for preventing cerebral ischemia-reperfusion injury.
Persistent Identifierhttp://hdl.handle.net/10722/160726
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, XMen_US
dc.contributor.authorChen, HSen_US
dc.contributor.authorXu, MJen_US
dc.contributor.authorShen, JGen_US
dc.date.accessioned2012-08-16T06:17:22Z-
dc.date.available2012-08-16T06:17:22Z-
dc.date.issued2013en_US
dc.identifier.citationActa Pharmacologica Sinica, 2013, v. 34 n. 1, p. 67–77en_US
dc.identifier.issn1671-4083-
dc.identifier.urihttp://hdl.handle.net/10722/160726-
dc.description.abstractIschemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic therapy often companies with cerebral ischemia-reperfusion injury, which are mediated by free radicals. As an important component of free radicals, reactive nitrogen species (RNS), including nitric oxide (NO) and peroxynitrite (ONOO(-)), play important roles in the process of cerebral ischemia-reperfusion injury. Ischemia-reperfusion results in the production of nitric oxide (NO) and peroxynitrite (ONOO(-)) in ischemic brain, which trigger numerous molecular cascades and lead to disruption of the blood brain barrier and exacerbate brain damage. There are few therapeutic strategies available for saving ischemic brains and preventing the subsequent brain damage. Recent evidence suggests that RNS could be a therapeutic target for the treatment of cerebral ischemia-reperfusion injury. Herein, we reviewed the recent progress regarding the roles of RNS in the process of cerebral ischemic-reperfusion injury and discussed the potentials of drug development that target NO and ONOO(-) to treat ischemic stroke. We conclude that modulation for RNS level could be an important therapeutic strategy for preventing cerebral ischemia-reperfusion injury.-
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html-
dc.relation.ispartofActa Pharmacologica Sinicaen_US
dc.subjectStroke-
dc.subjectCerebral ischemia-reperfusion injury-
dc.subjectReactive nitrogen species-
dc.subjectNitric oxide-
dc.subjectPeroxynitrite-
dc.titleTargeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injuryen_US
dc.typeArticleen_US
dc.identifier.emailShen, JG: shenjg@hku.hken_US
dc.identifier.authorityShen, J=rp00487en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/aps.2012.82-
dc.identifier.pmid22842734-
dc.identifier.pmcidPMC4086503-
dc.identifier.scopuseid_2-s2.0-84872059301-
dc.identifier.hkuros204179en_US
dc.identifier.hkuros228219-
dc.identifier.isiWOS:000314191000012-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 150114-

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