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Article: Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy

TitleEmerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy
Authors
KeywordsCancer therapy
Cell proliferation
Chinese medicine
Glycolysis
Curcuma longa
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence - Based Complementary and Alternative Medicine, 2012, v. 2012, article no. 873175 How to Cite?
AbstractMolecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells. Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates. Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen. This alternative metabolic characteristic is known as the 'Warburg Effect.' Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery. With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds. A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment. Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment. Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/160724
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Zen_US
dc.contributor.authorWang, Nen_US
dc.contributor.authorChen, Jen_US
dc.contributor.authorShen, Jen_US
dc.date.accessioned2012-08-16T06:17:21Z-
dc.date.available2012-08-16T06:17:21Z-
dc.date.issued2012en_US
dc.identifier.citationEvidence - Based Complementary and Alternative Medicine, 2012, v. 2012, article no. 873175en_US
dc.identifier.issn1741-427X-
dc.identifier.urihttp://hdl.handle.net/10722/160724-
dc.description.abstractMolecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells. Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates. Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen. This alternative metabolic characteristic is known as the 'Warburg Effect.' Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery. With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds. A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment. Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment. Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/-
dc.relation.ispartofEvidence - Based Complementary and Alternative Medicineen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCancer therapy-
dc.subjectCell proliferation-
dc.subjectChinese medicine-
dc.subjectGlycolysis-
dc.subjectCurcuma longa-
dc.titleEmerging glycolysis targeting and drug discovery from chinese medicine in cancer therapyen_US
dc.typeArticleen_US
dc.identifier.emailChen, J: abchen@hku.hken_US
dc.identifier.emailShen, J: shenjg@hku.hken_US
dc.identifier.authorityChen, J=rp01316en_US
dc.identifier.authorityShen, J=rp00487en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2012/873175-
dc.identifier.pmid22844340-
dc.identifier.pmcidPMC3403522-
dc.identifier.scopuseid_2-s2.0-84864957283-
dc.identifier.hkuros203871en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864957283&selection=ref&src=s&origin=recordpage-
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000307577200001-
dc.publisher.placeUnited Kingdom-
dc.identifier.scopusauthoridWang, Z=7410054221-
dc.identifier.scopusauthoridWang, N=55251266100-
dc.identifier.scopusauthoridChen, J=22733695400-
dc.identifier.scopusauthoridShen, J=7404929947-

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