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Article: Comparision of Two Determination Methods for Astragaloside Ⅳ in Radix Astragali

TitleComparision of Two Determination Methods for Astragaloside Ⅳ in Radix Astragali
黃芪藥材中黃芪甲苷含量測定的兩種方法的比較研究
Authors
KeywordsVolatilization (揮發作用)
Astragalus membranaceus (黃芪)
Hong Kong (香港)
Pharmacopoeias (藥典)
Light (光)
Issue Date2012
PublisherGuangzhou University of Chinese Medicine (廣州中醫藥大學).
Citation
Traditional Chinese Drug Research and Clinical Pharmacology, 2012, v. 22 n. 6, p. 659-662 How to Cite?
中药新药与临床药理, 2012, v. 22 n. 6, p. 659-662 How to Cite?
Abstractobjective To simplify the sample preparation method and to establish a rapid and accurate method for detemination of astragaloside IV in Radix Astragali. Methods Two methods described in Chinese Pharmacopoeia (2010)(ChP) and Hong Kong Chinese Materia Medica Standards(2005)(HKCMMS)were compared.Results: The content of astragaloside IV determined by HKCMMS showed a good linearity in the range of 20.56 411.20 μg/mL. The average recovery was 102.14% and RSD was 3.1%. SPSS 13.0 software was used for the statistical analysis of determination of astragaloside IV in 3 batches of Radix Astragali by the two methods, and T test results showed P= 0.951 > 0.05. Radix Astragali in 19 groups bought from Qingping market were determined by HKCMMS, and the results showed content of astragaloside IV was in the range of 0.15 0.84 mg/g. Conclusion The sample preparation method utilized in HKCMMS is simple, accurate, reliable and with good reproducibility, and there are no significant differences of the detemination results between Chp and HKCMMS.
目的 簡化樣品前處理方法,確立一種簡便快速、準確的黃芪藥材中黃芪甲苷的含量測定方法.方法 比較《中國藥典》和《香港中藥材標準》(港標)中黃芪甲苷的含量測定方法.結果 港標方法測定黃芪甲苷對照品濃度在20.56~411.20 μg/mL之間呈良好線性關系,r=0.9973.平均加樣回收率為102.14%,RSD為3.1%.采用SPSS 13.0軟件對兩種分析方法測得的3批藥材黃芪甲苷含量作統計分析,T檢驗結果P=0.951>0.05.采用港標方法對購自清平藥材市場19批藥材中黃芪甲苷含量進行測定,結果含量在0.15 ~ 0.84 mg/g之間.結論 港標方法重現性良好,結果準確可靠,且樣品前處理方法簡便,測得黃芪藥材中黃芪甲苷含量與中國藥典方法相比沒有統計學差異.
Persistent Identifierhttp://hdl.handle.net/10722/160723
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLiu, Hen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authoryang, Men_US
dc.contributor.authorChen, Jen_US
dc.contributor.authorWang, Den_US
dc.date.accessioned2012-08-16T06:17:21Z-
dc.date.available2012-08-16T06:17:21Z-
dc.date.issued2012en_US
dc.identifier.citationTraditional Chinese Drug Research and Clinical Pharmacology, 2012, v. 22 n. 6, p. 659-662en_US
dc.identifier.citation中药新药与临床药理, 2012, v. 22 n. 6, p. 659-662-
dc.identifier.issn1003-9783-
dc.identifier.urihttp://hdl.handle.net/10722/160723-
dc.description.abstractobjective To simplify the sample preparation method and to establish a rapid and accurate method for detemination of astragaloside IV in Radix Astragali. Methods Two methods described in Chinese Pharmacopoeia (2010)(ChP) and Hong Kong Chinese Materia Medica Standards(2005)(HKCMMS)were compared.Results: The content of astragaloside IV determined by HKCMMS showed a good linearity in the range of 20.56 411.20 μg/mL. The average recovery was 102.14% and RSD was 3.1%. SPSS 13.0 software was used for the statistical analysis of determination of astragaloside IV in 3 batches of Radix Astragali by the two methods, and T test results showed P= 0.951 > 0.05. Radix Astragali in 19 groups bought from Qingping market were determined by HKCMMS, and the results showed content of astragaloside IV was in the range of 0.15 0.84 mg/g. Conclusion The sample preparation method utilized in HKCMMS is simple, accurate, reliable and with good reproducibility, and there are no significant differences of the detemination results between Chp and HKCMMS.-
dc.description.abstract目的 簡化樣品前處理方法,確立一種簡便快速、準確的黃芪藥材中黃芪甲苷的含量測定方法.方法 比較《中國藥典》和《香港中藥材標準》(港標)中黃芪甲苷的含量測定方法.結果 港標方法測定黃芪甲苷對照品濃度在20.56~411.20 μg/mL之間呈良好線性關系,r=0.9973.平均加樣回收率為102.14%,RSD為3.1%.采用SPSS 13.0軟件對兩種分析方法測得的3批藥材黃芪甲苷含量作統計分析,T檢驗結果P=0.951>0.05.采用港標方法對購自清平藥材市場19批藥材中黃芪甲苷含量進行測定,結果含量在0.15 ~ 0.84 mg/g之間.結論 港標方法重現性良好,結果準確可靠,且樣品前處理方法簡便,測得黃芪藥材中黃芪甲苷含量與中國藥典方法相比沒有統計學差異.-
dc.languageengen_US
dc.publisherGuangzhou University of Chinese Medicine (廣州中醫藥大學).-
dc.relation.ispartofTraditional Chinese Drug Research and Clinical Pharmacologyen_US
dc.relation.ispartof中药新药与临床药理-
dc.subjectVolatilization (揮發作用)-
dc.subjectAstragalus membranaceus (黃芪)-
dc.subjectHong Kong (香港)-
dc.subjectPharmacopoeias (藥典)-
dc.subjectLight (光)-
dc.titleComparision of Two Determination Methods for Astragaloside Ⅳ in Radix Astragali-
dc.title黃芪藥材中黃芪甲苷含量測定的兩種方法的比較研究-
dc.typeArticleen_US
dc.identifier.emailChen, J: abchen@hku.hken_US
dc.identifier.authorityChen, J=rp01316en_US
dc.identifier.hkuros203870en_US
dc.identifier.volume22-
dc.identifier.issue6-
dc.identifier.spage659-
dc.identifier.epage662-
dc.publisher.placeGuangzhou (廣州)-

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