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Article: Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice

TitleDendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice
Authors
Issue Date2011
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimp
Citation
International Immunopharmacology, 2011, v. 11 n. 12, p. 2025-2032 How to Cite?
AbstractSjögren's syndrome (SS) is a chronic autoimmune disease with exocrine glands disorder. Our previous work demonstrated the protective effect of Dendrobium officinale polysaccharides (DP) both on the phenotypes of patients and animal model with SS. In this study, we expand these observations to explore the possible mechanisms. The experimental SS mice model was established with or without the administration of DP (20 mg/ml). The time frame of lymphocytes infiltration, apoptotic indicators such as Bax, Bcl-2 and caspase-3 were determined in submandibular gland (SG), as well as the subsequent mRNA expression of cytokines such as TNF-α, IL-1beta and IL-6. The expression and localization of aquaporin-5 (AQP-5) was examined by Western blot and immunofluorescent staining. As the result, DP could suppress the progressive lymphocytes infiltration and apoptosis, and balance the chaos of pro-inflammatory cytokines in the SG. Further, DP ameliorated the abnormalities of AQP-5 and maintained its functional importance of saliva secretion. In addition, the protection of AQP-5 by DP from human TNF-α was supported by an in vitro study on A-253 cell line. Our study further supported the efficacy of DP as the promising candidate for the therapy of SS. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/160702
ISSN
2015 Impact Factor: 2.551
2015 SCImago Journal Rankings: 0.941
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Xen_HK
dc.contributor.authorShaw, PCen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorZhang, Yen_HK
dc.date.accessioned2012-08-16T06:17:14Z-
dc.date.available2012-08-16T06:17:14Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Immunopharmacology, 2011, v. 11 n. 12, p. 2025-2032en_HK
dc.identifier.issn1567-5769en_HK
dc.identifier.urihttp://hdl.handle.net/10722/160702-
dc.description.abstractSjögren's syndrome (SS) is a chronic autoimmune disease with exocrine glands disorder. Our previous work demonstrated the protective effect of Dendrobium officinale polysaccharides (DP) both on the phenotypes of patients and animal model with SS. In this study, we expand these observations to explore the possible mechanisms. The experimental SS mice model was established with or without the administration of DP (20 mg/ml). The time frame of lymphocytes infiltration, apoptotic indicators such as Bax, Bcl-2 and caspase-3 were determined in submandibular gland (SG), as well as the subsequent mRNA expression of cytokines such as TNF-α, IL-1beta and IL-6. The expression and localization of aquaporin-5 (AQP-5) was examined by Western blot and immunofluorescent staining. As the result, DP could suppress the progressive lymphocytes infiltration and apoptosis, and balance the chaos of pro-inflammatory cytokines in the SG. Further, DP ameliorated the abnormalities of AQP-5 and maintained its functional importance of saliva secretion. In addition, the protection of AQP-5 by DP from human TNF-α was supported by an in vitro study on A-253 cell line. Our study further supported the efficacy of DP as the promising candidate for the therapy of SS. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimpen_HK
dc.relation.ispartofInternational Immunopharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshApoptosis - drug effectsen_HK
dc.subject.meshAquaporin 5 - metabolismen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCytokines - biosynthesisen_HK
dc.subject.meshDendrobium - chemistryen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInflammation - drug therapy - metabolismen_HK
dc.subject.meshLymphocytes - drug effectsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshPolysaccharides - therapeutic useen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - biosynthesisen_HK
dc.subject.meshSaliva - secretionen_HK
dc.subject.meshSjogren's Syndrome - therapyen_HK
dc.subject.meshSubmandibular Gland - drug effectsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshbcl-2-Associated X Protein - biosynthesisen_HK
dc.titleDendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome miceen_HK
dc.typeArticleen_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailZhang, Y: ybzhang@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityZhang, Y=rp01410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.intimp.2011.08.014en_HK
dc.identifier.pmid21890001-
dc.identifier.scopuseid_2-s2.0-81855164713en_HK
dc.identifier.hkuros202967en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81855164713&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2025en_HK
dc.identifier.epage2032en_HK
dc.identifier.isiWOS:000298460700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, X=36101204400en_HK
dc.identifier.scopusauthoridShaw, PC=35599523600en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridZhang, Y=23483121900en_HK
dc.identifier.citeulike9774969-

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