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Article: Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia

TitlePrefrontal deviations in function but not volume are putative endophenotypes for schizophrenia
Authors
KeywordsFamily
Genetic
MRI
Prefrontal
Twin
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://brain.oxfordjournals.org/
Citation
Brain, 2012, v. 135 n. 7, p. 2231-2244 How to Cite?
AbstractThis study sought to systematically investigate whether prefrontal cortex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investigating their presence in unaffected relatives, heritability, genetic overlap with the disorder itself and finally to contrast their performance on these criteria with putative neuropsychological indices of prefrontal functioning. We used a combined twin and family design and examined four prefrontal cortical regions of interest. Superior and inferior regions were significantly smaller in patients. However, the volumes of these same regions were normal in unaffected relatives and therefore, we could confirm that such deficits were not due to familial effects. Volumes of the prefrontal and orbital cortices were, however, moderately heritable, but neither shared a genetic overlap with schizophrenia. Total prefrontal cortical volume reductions shared a significant unique environmental overlap with the disorder, suggesting that the reductions were not familial. In contrast, prefrontal (executive) functioning deficits were present in the unaffected relatives, were moderately heritable and shared a substantial genetic overlap with liability to schizophrenia. These results suggest that the well recognized prefrontal volume reductions are not related to the same familial influences that increase schizophrenia liability and instead may be attributable to illness related biological changes or indeed confounded by illness trajectory, chronicity, medication or substance abuse, or in fact a combination of some or all of them. © The Author (2012). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/160678
ISSN
2015 Impact Factor: 10.103
2015 SCImago Journal Rankings: 6.097
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOwens, SFen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorSchmechtig, Aen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2012-08-16T06:16:20Z-
dc.date.available2012-08-16T06:16:20Z-
dc.date.issued2012en_HK
dc.identifier.citationBrain, 2012, v. 135 n. 7, p. 2231-2244en_HK
dc.identifier.issn0006-8950en_HK
dc.identifier.urihttp://hdl.handle.net/10722/160678-
dc.description.abstractThis study sought to systematically investigate whether prefrontal cortex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investigating their presence in unaffected relatives, heritability, genetic overlap with the disorder itself and finally to contrast their performance on these criteria with putative neuropsychological indices of prefrontal functioning. We used a combined twin and family design and examined four prefrontal cortical regions of interest. Superior and inferior regions were significantly smaller in patients. However, the volumes of these same regions were normal in unaffected relatives and therefore, we could confirm that such deficits were not due to familial effects. Volumes of the prefrontal and orbital cortices were, however, moderately heritable, but neither shared a genetic overlap with schizophrenia. Total prefrontal cortical volume reductions shared a significant unique environmental overlap with the disorder, suggesting that the reductions were not familial. In contrast, prefrontal (executive) functioning deficits were present in the unaffected relatives, were moderately heritable and shared a substantial genetic overlap with liability to schizophrenia. These results suggest that the well recognized prefrontal volume reductions are not related to the same familial influences that increase schizophrenia liability and instead may be attributable to illness related biological changes or indeed confounded by illness trajectory, chronicity, medication or substance abuse, or in fact a combination of some or all of them. © The Author (2012). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://brain.oxfordjournals.org/en_HK
dc.relation.ispartofBrainen_HK
dc.subjectFamilyen_HK
dc.subjectGeneticen_HK
dc.subjectMRIen_HK
dc.subjectPrefrontalen_HK
dc.subjectTwinen_HK
dc.titlePrefrontal deviations in function but not volume are putative endophenotypes for schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/brain/aws138en_HK
dc.identifier.pmid22693145-
dc.identifier.pmcidPMC3381723-
dc.identifier.scopuseid_2-s2.0-84863191771en_HK
dc.identifier.hkuros205264en_US
dc.identifier.hkuros223332-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863191771&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue7en_HK
dc.identifier.spage2231en_HK
dc.identifier.epage2244en_HK
dc.identifier.isiWOS:000305826300021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOwens, SF=36027261600en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridSchmechtig, A=26646923700en_HK
dc.identifier.scopusauthoridMurray, RM=46761365300en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK

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