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Article: Fate of the teratogenic and carcinogenic ochratoxin A in human perfused placenta

TitleFate of the teratogenic and carcinogenic ochratoxin A in human perfused placenta
Authors
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/toxlet
Citation
Toxicology Letters, 2012, v. 208 n. 1, p. 92-99 How to Cite?
AbstractOchratoxin A (OTA) is one of the most frequent mycotoxins detected in human blood worldwide. Apart from its well known nephrotoxicity, OTA-induced teratogenicity and carcinogenicity proven in animals are potential effects also in humans. Pregnant women have been exposed to this food contaminant via dietary exposure in a continuous and widespread manner. Although the transplacental transfer of OTA has been demonstrated in laboratory animals and the presence of OTA in human fetal samples has been reported, little is known about the role of human placenta in OTA toxicokinetics. In this study, human perfused placenta was used to reveal the actual placental toxicokinetics of OTA using concentrations found in serum of pregnant women. Moreover, the effect of protein concentration and biological significance of placental transporters on the OTA transfer in human placenta were also determined. Our study is the first to pursue the transfer of OTA through perfused human placenta. The transfer of OTA through term human placenta was barely detectable in all perfusions. Inhibitors of neither ABCG2 nor ABCC2 increased the transport of OTA to fetal circulation in placental perfusion, and thus these transporters apparently do not have biological significance in inhibiting transplacental transfer of OTA. Human albumin has inhibited OTA transfer through a tight monolayer of BeWo b30 cells. Finding from this study clearly contradict the existing epidemiological studies reporting higher OTA levels in fetal than in maternal circulation in vivo. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/160584
ISSN
2015 Impact Factor: 3.522
2015 SCImago Journal Rankings: 1.267
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWoo, CSJen_HK
dc.contributor.authorPartanen, Hen_HK
dc.contributor.authorMyllynen, Pen_HK
dc.contributor.authorVähäkangas, Ken_HK
dc.contributor.authorElNezami, Hen_HK
dc.date.accessioned2012-08-16T06:14:47Z-
dc.date.available2012-08-16T06:14:47Z-
dc.date.issued2012en_HK
dc.identifier.citationToxicology Letters, 2012, v. 208 n. 1, p. 92-99en_HK
dc.identifier.issn0378-4274en_HK
dc.identifier.urihttp://hdl.handle.net/10722/160584-
dc.description.abstractOchratoxin A (OTA) is one of the most frequent mycotoxins detected in human blood worldwide. Apart from its well known nephrotoxicity, OTA-induced teratogenicity and carcinogenicity proven in animals are potential effects also in humans. Pregnant women have been exposed to this food contaminant via dietary exposure in a continuous and widespread manner. Although the transplacental transfer of OTA has been demonstrated in laboratory animals and the presence of OTA in human fetal samples has been reported, little is known about the role of human placenta in OTA toxicokinetics. In this study, human perfused placenta was used to reveal the actual placental toxicokinetics of OTA using concentrations found in serum of pregnant women. Moreover, the effect of protein concentration and biological significance of placental transporters on the OTA transfer in human placenta were also determined. Our study is the first to pursue the transfer of OTA through perfused human placenta. The transfer of OTA through term human placenta was barely detectable in all perfusions. Inhibitors of neither ABCG2 nor ABCC2 increased the transport of OTA to fetal circulation in placental perfusion, and thus these transporters apparently do not have biological significance in inhibiting transplacental transfer of OTA. Human albumin has inhibited OTA transfer through a tight monolayer of BeWo b30 cells. Finding from this study clearly contradict the existing epidemiological studies reporting higher OTA levels in fetal than in maternal circulation in vivo. © 2011 Elsevier Ireland Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/toxleten_HK
dc.relation.ispartofToxicology Lettersen_HK
dc.subject.meshATP-Binding Cassette Transporters - metabolismen_HK
dc.subject.meshAlbumins - metabolismen_HK
dc.subject.meshCarcinogens - pharmacokineticsen_HK
dc.subject.meshCarrier Proteins - metabolismen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaternal-Fetal Exchangeen_HK
dc.subject.meshMultidrug Resistance-Associated Proteins - metabolismen_HK
dc.subject.meshNeoplasm Proteins - metabolismen_HK
dc.subject.meshOchratoxins - pharmacokineticsen_HK
dc.subject.meshOrganic Anion Transporters, Sodium-Independent - metabolismen_HK
dc.subject.meshPerfusionen_HK
dc.subject.meshPlacenta - metabolismen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshTeratogens - pharmacokineticsen_HK
dc.titleFate of the teratogenic and carcinogenic ochratoxin A in human perfused placentaen_HK
dc.typeArticleen_HK
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_HK
dc.identifier.authorityElNezami, H=rp00694en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.toxlet.2011.10.013en_HK
dc.identifier.pmid22037670-
dc.identifier.scopuseid_2-s2.0-80755184754en_HK
dc.identifier.hkuros203972en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80755184754&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume208en_HK
dc.identifier.issue1en_HK
dc.identifier.spage92en_HK
dc.identifier.epage99en_HK
dc.identifier.eissn1879-3169-
dc.identifier.isiWOS:000300121800014-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridWoo, CSJ=54384477300en_HK
dc.identifier.scopusauthoridPartanen, H=35201638100en_HK
dc.identifier.scopusauthoridMyllynen, P=7004099488en_HK
dc.identifier.scopusauthoridVähäkangas, K=7004284731en_HK
dc.identifier.scopusauthoridElNezami, H=6603690577en_HK
dc.identifier.citeulike9952806-

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