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Article: Exploiting p70 S6 kinase as a target for ovarian cancer

TitleExploiting p70 S6 kinase as a target for ovarian cancer
Authors
Keywordsovarian cancer
p70 S6 kinase
signaling networks
therapeutic target
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/ett
Citation
Expert Opinion On Therapeutic Targets, 2012, v. 16 n. 6, p. 619-630 How to Cite?
AbstractThe p70 S6 kinase (p70 S6K) is frequently active in ovarian and a wide range of cancer types, and it has a crucial role in several processes considered hallmarks of cancer. Therefore, blocking p70 S6K expression or activity may present a promising strategy for anticancer treatment. Areas covered: The current understanding of the molecular mechanisms that govern p70 S6K regulation as well as its tumorigenic effects, which are involved in the initiation and progression in ovarian cancer, in particular the emerging new role of p70 S6K in cell migration, which is a prerequisite of tumor metastasis. The p70 S6K cellular substrates and/or interacting proteins. The current state of drugs that target this kinase, either alone or in combination with other targeted agents. Expert opinion: Targeting p70 S6K through the use of small-molecule inhibitors, microRNAs and natural compounds may represent a beneficial new avenue for cancer therapy and opens new areas of investigation in p70 S6K biology. © 2012 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/160578
ISSN
2015 Impact Factor: 4.798
2015 SCImago Journal Rankings: 2.025
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, CKMen_HK
dc.contributor.authorWong, ASTen_HK
dc.date.accessioned2012-08-16T06:14:45Z-
dc.date.available2012-08-16T06:14:45Z-
dc.date.issued2012en_HK
dc.identifier.citationExpert Opinion On Therapeutic Targets, 2012, v. 16 n. 6, p. 619-630en_HK
dc.identifier.issn1472-8222en_HK
dc.identifier.urihttp://hdl.handle.net/10722/160578-
dc.description.abstractThe p70 S6 kinase (p70 S6K) is frequently active in ovarian and a wide range of cancer types, and it has a crucial role in several processes considered hallmarks of cancer. Therefore, blocking p70 S6K expression or activity may present a promising strategy for anticancer treatment. Areas covered: The current understanding of the molecular mechanisms that govern p70 S6K regulation as well as its tumorigenic effects, which are involved in the initiation and progression in ovarian cancer, in particular the emerging new role of p70 S6K in cell migration, which is a prerequisite of tumor metastasis. The p70 S6K cellular substrates and/or interacting proteins. The current state of drugs that target this kinase, either alone or in combination with other targeted agents. Expert opinion: Targeting p70 S6K through the use of small-molecule inhibitors, microRNAs and natural compounds may represent a beneficial new avenue for cancer therapy and opens new areas of investigation in p70 S6K biology. © 2012 Informa UK, Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/etten_HK
dc.relation.ispartofExpert Opinion on Therapeutic Targetsen_HK
dc.rightsExpert Opinion on Therapeutic Targets. Copyright © Informa Healthcare.-
dc.subjectovarian canceren_HK
dc.subjectp70 S6 kinaseen_HK
dc.subjectsignaling networksen_HK
dc.subjecttherapeutic targeten_HK
dc.subject.meshAnimals-
dc.subject.meshBiological Agents - therapeutic use-
dc.subject.meshFemale-
dc.subject.meshOvarian Neoplasms - drug therapy - metabolism-
dc.subject.meshRibosomal Protein S6 Kinases, 70-kDa - antagonists and inhibitors - metabolism-
dc.titleExploiting p70 S6 kinase as a target for ovarian canceren_HK
dc.typeArticleen_HK
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_HK
dc.identifier.authorityWong, AST=rp00805en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1517/14728222.2012.684680en_HK
dc.identifier.pmid22564017-
dc.identifier.scopuseid_2-s2.0-84861326416en_HK
dc.identifier.hkuros203400en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861326416&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue6en_HK
dc.identifier.spage619en_HK
dc.identifier.epage630en_HK
dc.identifier.isiWOS:000304091400008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridIp, CKM=23987652100en_HK
dc.identifier.scopusauthoridWong, AST=23987963300en_HK

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