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Conference Paper: Treatment with cromolyn sodium at early reperfusion but not before ischemia attenuates intestinal ischemia/reperfusion induced lung injury in mice

TitleTreatment with cromolyn sodium at early reperfusion but not before ischemia attenuates intestinal ischemia/reperfusion induced lung injury in mice
Authors
KeywordsBiology
Issue Date2012
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Experimental Biology Annual Meeting (EB 2012), San Diego, CA., 21-25 April 2012. in The FASEB Journal, 2012, v. 26 Meeting abstracts suppl., abstract no. lb553 How to Cite?
AbstractMast cell degranulation plays a key role in small intestinal ischemia/reperfusion (IIR)-induced lung injury. Studies showed that administration of mast cell stabilizers both before ischemia and at reperfusion can dramatically attenuate IIR injury. However, the relative effectiveness of mast cell inhibition before ischemia or during reperfusion on IIR-induced lung injury has yet to be determined. Cromolyn Sodium (mast cell stabilizer, 25mg/kg i.v.) was administrated either for 15 min before inducing small intestinal ischemia in mice by occluding the superior mesenteric artery for 30 min, or for 15 min upon reperfusion. Small IIR resulted in significant intestinal injury manifested as increased Chiu's scores with concomitant lung injury evidenced as elevations in lung injury scores, lung wet/dry weight ratio and increases in lung tissue tryptase and mast cell protease 7 protein expressions in lung in 3 hours after reperfusion, accompanied with decreased survival rates at 3 day after reperfusion (all P<0.05, vs. Sham control). All these changes were significantly alleviated in mice treated with Cromolyn Sodium on reperfusion (P<0.05, vs. IIR untreated) but not in mice pre-treated with Cromolyn Sodium. The results indicate mast cell inhibition at early reperfusion is an effective therapeutic approach in attenuating intestinal IR mediated remote organ injury.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/160561
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorGan, Xen_US
dc.contributor.authorLuo, CFen_US
dc.contributor.authorLuo, GJen_US
dc.contributor.authorLi, Sen_US
dc.contributor.authorHei, Zen_US
dc.contributor.authorXia, Zen_US
dc.date.accessioned2012-08-16T06:14:22Z-
dc.date.available2012-08-16T06:14:22Z-
dc.date.issued2012en_US
dc.identifier.citationExperimental Biology Annual Meeting (EB 2012), San Diego, CA., 21-25 April 2012. in The FASEB Journal, 2012, v. 26 Meeting abstracts suppl., abstract no. lb553en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/160561-
dc.descriptionOpen Access Journal-
dc.description.abstractMast cell degranulation plays a key role in small intestinal ischemia/reperfusion (IIR)-induced lung injury. Studies showed that administration of mast cell stabilizers both before ischemia and at reperfusion can dramatically attenuate IIR injury. However, the relative effectiveness of mast cell inhibition before ischemia or during reperfusion on IIR-induced lung injury has yet to be determined. Cromolyn Sodium (mast cell stabilizer, 25mg/kg i.v.) was administrated either for 15 min before inducing small intestinal ischemia in mice by occluding the superior mesenteric artery for 30 min, or for 15 min upon reperfusion. Small IIR resulted in significant intestinal injury manifested as increased Chiu's scores with concomitant lung injury evidenced as elevations in lung injury scores, lung wet/dry weight ratio and increases in lung tissue tryptase and mast cell protease 7 protein expressions in lung in 3 hours after reperfusion, accompanied with decreased survival rates at 3 day after reperfusion (all P<0.05, vs. Sham control). All these changes were significantly alleviated in mice treated with Cromolyn Sodium on reperfusion (P<0.05, vs. IIR untreated) but not in mice pre-treated with Cromolyn Sodium. The results indicate mast cell inhibition at early reperfusion is an effective therapeutic approach in attenuating intestinal IR mediated remote organ injury.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titleTreatment with cromolyn sodium at early reperfusion but not before ischemia attenuates intestinal ischemia/reperfusion induced lung injury in miceen_US
dc.typeConference_Paperen_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros205137en_US
dc.identifier.volume26en_US
dc.identifier.issueMeeting abstracts suppl.-
dc.publisher.placeUnited States-
dc.description.otherExperimental Biology Annual Meeting (EB 2012), San Diego, CA., 21-25 April 2012. in The FASEB Journal, 2012, v. 26 Meeting abstracts suppl., abstract no. lb553-

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