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Conference Paper: Application of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysis

TitleApplication of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysis
Authors
Issue Date2012
PublisherAmerican Association of Cancer Research.
Citation
The 103rd Annual Meeting of American Association of Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. How to Cite?
AbstractBACKGROUND AND AIMS: Esophageal cancer (EC) is a deadly disease with a very low 5-year survival rate. The incidence of EC shows great geographical variations with high prevalence in Northern China. Although epidemiological studies suggest that environmental factors may be etiologic factors of EC, strong evidence supporting a causative role of genetic factors in familial EC comes from i) familial aggregation of EC in Yangcheng County, ii) the distinct high EC incidence in Chaoshan migrants to Nanao, and iii) molecular genetic studies such as BRCA2 germline mutations. Recent technological advances allow the identification of long regions of homozygosity (known as IBD segments) in genomic DNAs, which represent the sharing of a common ancestor in those regions, using the high density SNP arrays. Previous studies suggest that a high rate of consanguinity, which produces germline genomic homozygosity, is associated with cancers. We aim to use the IBD approach for mapping the susceptibility locus with low-penetrance SNPs in hereditary ESCC patients in Henan, one of the highest ESCC risk regions in the world. Screening programs based on knowledge of founder mutations may reduce cancer mortality by prevention. Thus, our second aim is to assess if a founder effect exists and predisposes individual…
DescriptionPoster Section 23 - Genetic Studies of Risk or Prognosis: abstract no. 2637
Persistent Identifierhttp://hdl.handle.net/10722/160409

 

DC FieldValueLanguage
dc.contributor.authorKo, JMYen_US
dc.contributor.authorWang, LDen_US
dc.contributor.authorSong, Xen_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-08-16T06:10:14Z-
dc.date.available2012-08-16T06:10:14Z-
dc.date.issued2012en_US
dc.identifier.citationThe 103rd Annual Meeting of American Association of Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/160409-
dc.descriptionPoster Section 23 - Genetic Studies of Risk or Prognosis: abstract no. 2637-
dc.description.abstractBACKGROUND AND AIMS: Esophageal cancer (EC) is a deadly disease with a very low 5-year survival rate. The incidence of EC shows great geographical variations with high prevalence in Northern China. Although epidemiological studies suggest that environmental factors may be etiologic factors of EC, strong evidence supporting a causative role of genetic factors in familial EC comes from i) familial aggregation of EC in Yangcheng County, ii) the distinct high EC incidence in Chaoshan migrants to Nanao, and iii) molecular genetic studies such as BRCA2 germline mutations. Recent technological advances allow the identification of long regions of homozygosity (known as IBD segments) in genomic DNAs, which represent the sharing of a common ancestor in those regions, using the high density SNP arrays. Previous studies suggest that a high rate of consanguinity, which produces germline genomic homozygosity, is associated with cancers. We aim to use the IBD approach for mapping the susceptibility locus with low-penetrance SNPs in hereditary ESCC patients in Henan, one of the highest ESCC risk regions in the world. Screening programs based on knowledge of founder mutations may reduce cancer mortality by prevention. Thus, our second aim is to assess if a founder effect exists and predisposes individual…-
dc.languageengen_US
dc.publisherAmerican Association of Cancer Research.-
dc.relation.ispartofProceedings of the 103rd Annual Meeting of American Association of Cancer Research, AACR 2012en_US
dc.titleApplication of identity-by-descent (IBD) approach to genetic mapping of susceptibility locus in hereditary esophageal squamous cell carcinoma (ESCC) by high density SNP array analysisen_US
dc.typeConference_Paperen_US
dc.identifier.emailKo, JMY: joko@hku.hken_US
dc.identifier.emailLung, ML: mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros202635en_US
dc.publisher.placeUnited States-

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