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Conference Paper: Surface enhanced polyetheretherketone materials for orthopaedic implantation

TitleSurface enhanced polyetheretherketone materials for orthopaedic implantation
Authors
Issue Date2010
PublisherThe Conference.
Citation
The 7th SICOT/SIROT Annual International Conference combined Meeting with the Swedish Orthopaedic Association (SOF), Gothenburg, Sweden, 31 August-3 September 2010. In Abstracts of Oral Presentations, 2010, p. 440, abstract no. 26041 How to Cite?
AbstractPolyetheretherketone (PEEK) has been widely applied as bone substitute in various orthopaedic implantations. However, its bioinertness associates with the unsatisfactory bone-implant integration. Although its bioactivity can be improved by incorporating additional bioactive substance into PEEK matrix, alternation of its original mechanical properties is concerned. Alternatively, surface modification using plasma implantation has been developed in order to incorporate new biofunctional groups onto PEEK surface. This study aims at investigating the feasibility of ammonia and water plasma treatment in enhancing the surface bioactivity of PEEK. The samples measured 5mm in diameter and 3 mm thick were prepared. Water and Ammonia plasma treatments were applied at implantation energy of 10kV, 20kV and 30kV for 2 hours. Surface bioactivity assessments including cell adhesion and proliferation were conducted by using SaOs-2 cells. Alkaline phosphatase (ALP) expression and mineralization assay were applied. The minerals formed on the surfaces were qualified by energy-dispersive X-ray spectroscopy (EDX). The result of cell adhesion testing revealed that more cells attached to all the samples except NH3 10kV as compared with the untreated (p<0.05). The ALP expression of all 30kV samples was higher at Day 7 (p<0.05). However, the ALP expression and mineralization of the 30kV treated samples were not significantly different from the untreated. Apatite-like structure found on the NH3 treated surface was Ca and P rich substances. Our biological testing results suggested that the bioactivity of PEEK could be enhanced by water and ammonia plasma treatments in particular to the initial cell attachment and proliferation.
DescriptionSession - Biomaterials / Cartilage Repair: abstract no. 26041
Persistent Identifierhttp://hdl.handle.net/10722/160387

 

DC FieldValueLanguage
dc.contributor.authorYeung, Ken_US
dc.contributor.authorLui, SCen_US
dc.contributor.authorChu, Pen_US
dc.contributor.authorLuk, Ken_US
dc.contributor.authorCheung, Ken_US
dc.date.accessioned2012-08-16T06:09:15Z-
dc.date.available2012-08-16T06:09:15Z-
dc.date.issued2010en_US
dc.identifier.citationThe 7th SICOT/SIROT Annual International Conference combined Meeting with the Swedish Orthopaedic Association (SOF), Gothenburg, Sweden, 31 August-3 September 2010. In Abstracts of Oral Presentations, 2010, p. 440, abstract no. 26041en_US
dc.identifier.urihttp://hdl.handle.net/10722/160387-
dc.descriptionSession - Biomaterials / Cartilage Repair: abstract no. 26041-
dc.description.abstractPolyetheretherketone (PEEK) has been widely applied as bone substitute in various orthopaedic implantations. However, its bioinertness associates with the unsatisfactory bone-implant integration. Although its bioactivity can be improved by incorporating additional bioactive substance into PEEK matrix, alternation of its original mechanical properties is concerned. Alternatively, surface modification using plasma implantation has been developed in order to incorporate new biofunctional groups onto PEEK surface. This study aims at investigating the feasibility of ammonia and water plasma treatment in enhancing the surface bioactivity of PEEK. The samples measured 5mm in diameter and 3 mm thick were prepared. Water and Ammonia plasma treatments were applied at implantation energy of 10kV, 20kV and 30kV for 2 hours. Surface bioactivity assessments including cell adhesion and proliferation were conducted by using SaOs-2 cells. Alkaline phosphatase (ALP) expression and mineralization assay were applied. The minerals formed on the surfaces were qualified by energy-dispersive X-ray spectroscopy (EDX). The result of cell adhesion testing revealed that more cells attached to all the samples except NH3 10kV as compared with the untreated (p<0.05). The ALP expression of all 30kV samples was higher at Day 7 (p<0.05). However, the ALP expression and mineralization of the 30kV treated samples were not significantly different from the untreated. Apatite-like structure found on the NH3 treated surface was Ca and P rich substances. Our biological testing results suggested that the bioactivity of PEEK could be enhanced by water and ammonia plasma treatments in particular to the initial cell attachment and proliferation.-
dc.languageengen_US
dc.publisherThe Conference.-
dc.relation.ispartofAbstracts of Oral Presentationsen_US
dc.titleSurface enhanced polyetheretherketone materials for orthopaedic implantationen_US
dc.typeConference_Paperen_US
dc.identifier.emailYeung, K: wkkyeung@hku.hken_US
dc.identifier.emailLuk, K: hcm21000@hku.hken_US
dc.identifier.emailCheung, K: cheungmc@hku.hken_US
dc.identifier.authorityYeung, K=rp00309en_US
dc.identifier.authorityLuk, K=rp00333en_US
dc.identifier.authorityCheung, K=rp00387en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros197024en_US
dc.identifier.hkuros204568-
dc.identifier.spage440-
dc.identifier.epage440-
dc.publisher.placeSweden-

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