Conference Paper: Age-specific incidence rate in severe or symptomatic infection due to pandemic H1N1 2009 influenza virus

TitleAge-specific incidence rate in severe or symptomatic infection due to pandemic H1N1 2009 influenza virus
Authors
Issue Date2011
PublisherIDSA Boston 2011. The Conference program's website is located at https://idsa.confex.com/idsa/2011/webprogram
Citation
The 49th Annual Meeting of the Infectious Diseases Society of America (IDSA 2011), Boston, MA., 20-23 October 2011. How to Cite?
AbstractBACKGROUND: Age-specific incidence of the 2009 pandemic influenza provides the scientific basis of public health policies and the basic science research on the age-related susceptibility to influenza. While previous epidemiological studies provided vital information for public health policies, most did not incorporate age-specific data of asymptomatic, symptomatic and severe infection in the analysis. In this study, we incorporated data from seroprevalence and microbiologically-confirmed infection to estimate the relative impact of the pandemic influenza on various age groups. METHODS: For the determination of pre-pandemic and post-pandemic seroprevalence, archived plasma samples randomly collected at the clinical biochemistry department of Queen Mary Hospital in the years 2007 and 2010 were used respectively. Microbiologically-confirmed cases and severe cases reported to the Centre for Health Protection (CHP) from May 1, 2009 to May 23, 2010 were included in our analysis. This study was approved by the institutional review board of the Hospital Authority of Hong Kong. RESULTS: 795 and 1000 plasma samples were collected in 2007 and 2010 respectively. In 2007, 8.7% and 14.2% of individuals had HI titers ≥40 and ≥10 respectively. The pre-existing cross-reactive antibodies were mainly found in patients aged >70 years old. In 2010, the overall proportion of individuals with HI titers ≥40 and ≥10 is 23.2% and 42.2%. The highest overall microbiologically-confirmed incidence rate was found in the 0-10 year age group, and decreased with increasing age (ρ=-1.0, p<0.01). A total of 282 severe cases were reported with a mean age was 47.6 years. The incidence rate of severe cases showed an apparent bimodal age distribution, with higher incidence rate in the age group 0-10 and those older than 50 years old, and the highest incidence rate being those between 51 and 60 years old. CONCLUSION: While the young adults were most commonly infected, the clinical consequence is most alarming in children and older adults aged over 50 years. Public policies should continue to target this high risk group.
DescriptionPoster Abstract Session - Influenza and H1N1 Diagnosis, Epidemiology, and Viral Outcome: abstract no. 1133
Persistent Identifierhttp://hdl.handle.net/10722/160355

 

DC FieldValueLanguage
dc.contributor.authorTo, KKW-
dc.contributor.authorZhang, AJX-
dc.contributor.authorTse, H-
dc.contributor.authorChan, KH-
dc.contributor.authorLi, CPY-
dc.contributor.authorGuo, KY-
dc.contributor.authorHung, IFN-
dc.contributor.authorChen, H-
dc.contributor.authorTam, S-
dc.contributor.authorTsang, THF-
dc.contributor.authorYuen, KY-
dc.date.accessioned2012-08-16T06:08:34Z-
dc.date.available2012-08-16T06:08:34Z-
dc.date.issued2011-
dc.identifier.citationThe 49th Annual Meeting of the Infectious Diseases Society of America (IDSA 2011), Boston, MA., 20-23 October 2011.-
dc.identifier.urihttp://hdl.handle.net/10722/160355-
dc.descriptionPoster Abstract Session - Influenza and H1N1 Diagnosis, Epidemiology, and Viral Outcome: abstract no. 1133-
dc.description.abstractBACKGROUND: Age-specific incidence of the 2009 pandemic influenza provides the scientific basis of public health policies and the basic science research on the age-related susceptibility to influenza. While previous epidemiological studies provided vital information for public health policies, most did not incorporate age-specific data of asymptomatic, symptomatic and severe infection in the analysis. In this study, we incorporated data from seroprevalence and microbiologically-confirmed infection to estimate the relative impact of the pandemic influenza on various age groups. METHODS: For the determination of pre-pandemic and post-pandemic seroprevalence, archived plasma samples randomly collected at the clinical biochemistry department of Queen Mary Hospital in the years 2007 and 2010 were used respectively. Microbiologically-confirmed cases and severe cases reported to the Centre for Health Protection (CHP) from May 1, 2009 to May 23, 2010 were included in our analysis. This study was approved by the institutional review board of the Hospital Authority of Hong Kong. RESULTS: 795 and 1000 plasma samples were collected in 2007 and 2010 respectively. In 2007, 8.7% and 14.2% of individuals had HI titers ≥40 and ≥10 respectively. The pre-existing cross-reactive antibodies were mainly found in patients aged >70 years old. In 2010, the overall proportion of individuals with HI titers ≥40 and ≥10 is 23.2% and 42.2%. The highest overall microbiologically-confirmed incidence rate was found in the 0-10 year age group, and decreased with increasing age (ρ=-1.0, p<0.01). A total of 282 severe cases were reported with a mean age was 47.6 years. The incidence rate of severe cases showed an apparent bimodal age distribution, with higher incidence rate in the age group 0-10 and those older than 50 years old, and the highest incidence rate being those between 51 and 60 years old. CONCLUSION: While the young adults were most commonly infected, the clinical consequence is most alarming in children and older adults aged over 50 years. Public policies should continue to target this high risk group.-
dc.languageeng-
dc.publisherIDSA Boston 2011. The Conference program's website is located at https://idsa.confex.com/idsa/2011/webprogram-
dc.relation.ispartofAnnual Meeting of the Infectious Diseases Society of America, IDSA 2011-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAge-specific incidence rate in severe or symptomatic infection due to pandemic H1N1 2009 influenza virus-
dc.typeConference_Paper-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailZhang, AJX: zhangajx@hkucc.hku.hk-
dc.identifier.emailTse, H: htse@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailLi, CPY: canlee@hku.hk-
dc.identifier.emailGuo, KY: guoky@hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hku.hk-
dc.identifier.emailChen, H: hlchen@hku.hk-
dc.identifier.emailTam, S: stam@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityZhang, AJX=rp00413-
dc.identifier.authorityTse, H=rp00519-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityChen, H=rp00383-
dc.identifier.authorityYuen, KY=rp00366-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros203979-
dc.identifier.hkuros232423-
dc.publisher.placeUnited States-
dc.description.otherThe 49th Annual Meeting of the Infectious Diseases Society of America (IDSA 2011), Boston, MA., 20-23 October 2011.-

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