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Conference Paper: Genetic deletion or pharmacological inhibition of aldose reductase protects the retina in a mouse model of ischemia-induced retinopathy

TitleGenetic deletion or pharmacological inhibition of aldose reductase protects the retina in a mouse model of ischemia-induced retinopathy
Authors
Keywords571 ischemia
606 neovascularization
594 microglia
Issue Date2012
PublisherAssociation for Research in Vision and Ophthalmology, Inc..
Citation
The 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, 6-10 May 2012. How to Cite?
AbstractPURPOSE: Retinal neovascularization is a major pathologic process leading to blindness in many ocular diseases including retinopathy of prematurity. Oxidative stress has been reported to be highly related to its pathogenesis. We previously demonstrated that genetic deletion or pharmacological inhibition of aldose reductase (AR), a rate limiting enzyme in the polyol pathway, prevented oxidative stress and blood vessel leakage in ...
DescriptionPoster Session 520 - Retinopathy of Prematurity II: 5883/A503
Persistent Identifierhttp://hdl.handle.net/10722/160134

 

DC FieldValueLanguage
dc.contributor.authorFu, Zen_US
dc.contributor.authorLi, SYen_US
dc.contributor.authorChung, SKen_US
dc.contributor.authorWong, Den_US
dc.contributor.authorLo, ACYen_US
dc.date.accessioned2012-08-16T06:04:09Z-
dc.date.available2012-08-16T06:04:09Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, 6-10 May 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/160134-
dc.descriptionPoster Session 520 - Retinopathy of Prematurity II: 5883/A503-
dc.description.abstractPURPOSE: Retinal neovascularization is a major pathologic process leading to blindness in many ocular diseases including retinopathy of prematurity. Oxidative stress has been reported to be highly related to its pathogenesis. We previously demonstrated that genetic deletion or pharmacological inhibition of aldose reductase (AR), a rate limiting enzyme in the polyol pathway, prevented oxidative stress and blood vessel leakage in ...-
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology, Inc..-
dc.relation.ispartofARVO 2012 Annual Meetingen_US
dc.subject571 ischemia-
dc.subject606 neovascularization-
dc.subject594 microglia-
dc.titleGenetic deletion or pharmacological inhibition of aldose reductase protects the retina in a mouse model of ischemia-induced retinopathyen_US
dc.typeConference_Paperen_US
dc.identifier.emailFu, Z: h0794142@hku.hken_US
dc.identifier.emailLi, SY: sukyeeli@hku.hken_US
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_US
dc.identifier.emailWong, D: shdwong@hku.hken_US
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hk-
dc.identifier.authorityChung, SK=rp00381en_US
dc.identifier.authorityWong, D=rp00516en_US
dc.identifier.authorityLo, ACY=rp00425en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros205732en_US
dc.publisher.placeUnited States-
dc.description.otherThe 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL, 6-10 May 2012.-

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