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Conference Paper: Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide

TitleEndoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide
Authors
KeywordsMedical sciences
Psychiatry and neurology gerontology and geriatrics
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.alzheimersanddementia.org/
Citation
The 2012 International Conference of the Alzheimer’s Association (AAIC), Vancouver, BC., Canada, 14-19 July 2012. In Alzheimer's & Dementia, 2012, v. 8 n. 4 suppl., p. P252-P253 How to Cite?
AbstractBACKGROUND: Autophagy has long been considered to be one of the mechanisms for cells to clear damaged intracellular organelles. It has not been clear of how autophagy or formation of autophagic vacuoles is initiated in Alzheimer's disease (AD) or β-amyloid (Aβ) peptide neurotoxicity in neurons. We have reported that cultured neurons exposed to oligomeric Aβ peptide display aggregation and collapse of the endoplasmic reticulum (ER). This is due to the instability of microtubules leading to detachment of the ER from microtubules. Concomitantly, increase of autophagic vacuoles can be observed after aggregation of the ER. The aim of this study is to investigate molecular mechanisms of how aggregation of the ER initiates formation of auto…
DescriptionThis journal suppl. contain abstracts of AAIC2012
Persistent Identifierhttp://hdl.handle.net/10722/160129
ISSN
2015 Impact Factor: 11.619
2015 SCImago Journal Rankings: 4.289

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_US
dc.contributor.authorZhang, NQen_US
dc.contributor.authorHung, Cen_US
dc.contributor.authorWuwongse, Sen_US
dc.contributor.authorHo, YSen_US
dc.date.accessioned2012-08-16T06:04:07Z-
dc.date.available2012-08-16T06:04:07Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 International Conference of the Alzheimer’s Association (AAIC), Vancouver, BC., Canada, 14-19 July 2012. In Alzheimer's & Dementia, 2012, v. 8 n. 4 suppl., p. P252-P253en_US
dc.identifier.issn1552-5260-
dc.identifier.urihttp://hdl.handle.net/10722/160129-
dc.descriptionThis journal suppl. contain abstracts of AAIC2012-
dc.description.abstractBACKGROUND: Autophagy has long been considered to be one of the mechanisms for cells to clear damaged intracellular organelles. It has not been clear of how autophagy or formation of autophagic vacuoles is initiated in Alzheimer's disease (AD) or β-amyloid (Aβ) peptide neurotoxicity in neurons. We have reported that cultured neurons exposed to oligomeric Aβ peptide display aggregation and collapse of the endoplasmic reticulum (ER). This is due to the instability of microtubules leading to detachment of the ER from microtubules. Concomitantly, increase of autophagic vacuoles can be observed after aggregation of the ER. The aim of this study is to investigate molecular mechanisms of how aggregation of the ER initiates formation of auto…-
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.alzheimersanddementia.org/-
dc.relation.ispartofAlzheimer's & Dementiaen_US
dc.subjectMedical sciences-
dc.subjectPsychiatry and neurology gerontology and geriatrics-
dc.titleEndoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptideen_US
dc.typeConference_Paperen_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.emailHo, YS: janiceys@hku.hken_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jalz.2012.05.673-
dc.identifier.hkuros204912en_US
dc.identifier.volume8en_US
dc.identifier.issue4 suppl.en_US
dc.identifier.spageP252en_US
dc.identifier.epageP253en_US
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 140122-

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