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Article: The relationship between tuberculosis and influenza death during the influenza (H1N1) pandemic from 1918-19

TitleThe relationship between tuberculosis and influenza death during the influenza (H1N1) pandemic from 1918-19
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cmmm/
Citation
Computational and Mathematical Methods in Medicine, 2012, v. 2012, article no. 124861 How to Cite?
AbstractThe epidemiological mechanisms behind the W-shaped age-specific influenza mortality during the Spanish influenza (H1N1) pandemic 1918-19 have yet to be fully clarified. The present study aimed to develop a formal hypothesis: tuberculosis (TB) was associated with the W-shaped influenza mortality from 1918-19. Three pieces of epidemiological information were assessed: (i) the epidemic records containing the age-specific numbers of cases and deaths of influenza from 1918-19, (ii) an outbreak record of influenza in a Swiss TB sanatorium during the pandemic, and (iii) the age-dependent TB mortality over time in the early 20th century. Analyzing the data (i), we found that the W-shaped pattern was not only seen in mortality but also in the age-specific case fatality ratio, suggesting the presence of underlying age-specific risk factor(s) of influenza death among young adults. From the data (ii), TB was shown to be associated with influenza death (P = 0.09), and there was no influenza death among non-TB controls. The data (iii) were analyzed by employing the age-period-cohort model, revealing harvesting effect in the period function of TB mortality shortly after the 1918-19 pandemic. These findings suggest that it is worthwhile to further explore the role of TB in characterizing the age-specific risk of influenza death.
Persistent Identifierhttp://hdl.handle.net/10722/160036
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.415
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOei, Wen_US
dc.contributor.authorNishiura, Hen_US
dc.date.accessioned2012-08-16T06:01:30Z-
dc.date.available2012-08-16T06:01:30Z-
dc.date.issued2012en_US
dc.identifier.citationComputational and Mathematical Methods in Medicine, 2012, v. 2012, article no. 124861en_US
dc.identifier.issn1748-670X-
dc.identifier.urihttp://hdl.handle.net/10722/160036-
dc.description.abstractThe epidemiological mechanisms behind the W-shaped age-specific influenza mortality during the Spanish influenza (H1N1) pandemic 1918-19 have yet to be fully clarified. The present study aimed to develop a formal hypothesis: tuberculosis (TB) was associated with the W-shaped influenza mortality from 1918-19. Three pieces of epidemiological information were assessed: (i) the epidemic records containing the age-specific numbers of cases and deaths of influenza from 1918-19, (ii) an outbreak record of influenza in a Swiss TB sanatorium during the pandemic, and (iii) the age-dependent TB mortality over time in the early 20th century. Analyzing the data (i), we found that the W-shaped pattern was not only seen in mortality but also in the age-specific case fatality ratio, suggesting the presence of underlying age-specific risk factor(s) of influenza death among young adults. From the data (ii), TB was shown to be associated with influenza death (P = 0.09), and there was no influenza death among non-TB controls. The data (iii) were analyzed by employing the age-period-cohort model, revealing harvesting effect in the period function of TB mortality shortly after the 1918-19 pandemic. These findings suggest that it is worthwhile to further explore the role of TB in characterizing the age-specific risk of influenza death.-
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cmmm/-
dc.relation.ispartofComputational and Mathematical Methods in Medicineen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCytokines - metabolism-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - metabolism-
dc.subject.meshInfluenza, Human - complications - mortality-
dc.subject.meshModels, Statistical-
dc.subject.meshTuberculosis - complications - mortality-
dc.titleThe relationship between tuberculosis and influenza death during the influenza (H1N1) pandemic from 1918-19en_US
dc.typeArticleen_US
dc.identifier.emailNishiura, H: nishiura@hku.hken_US
dc.identifier.authorityNishiura, H=rp01488en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2012/124861-
dc.identifier.pmid22848231-
dc.identifier.pmcidPMC3405656-
dc.identifier.scopuseid_2-s2.0-84864913582-
dc.identifier.hkuros203810en_US
dc.identifier.volume2012, article no. 124861en_US
dc.identifier.isiWOS:000307700900001-
dc.publisher.placeUnited Kingdom-

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