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Article: What made her give up her breasts: a qualitative study on decisional considerations for contralateral prophylactic mastectomy among breast cancer survivors undergoing BRCA1/2 genetic testing

TitleWhat made her give up her breasts: a qualitative study on decisional considerations for contralateral prophylactic mastectomy among breast cancer survivors undergoing BRCA1/2 genetic testing
Authors
KeywordsBreast and ovarian cancer
Qualitative
Prophylactic mastectomy
BRCA1 and BRCA2
Genetic testing
Issue Date2012
PublisherAsian Pacific Organization for Cancer Prevention. The Journal's web site is located at http://www.apocp.org
Citation
Asian Pacific Journal of Cancer Prevention, 2012, v. 13 n. 5, p. 2241-2247 How to Cite?
AbstractOBJECTIVE: This qualitative study retrospectively examined the experience and psychological impact of contralateral prophylactic mastectomy (CPM) among Southern Chinese females with unilateral breast cancer history who underwent BRCA1/2 genetic testing. Limited knowledge is available on this topic especially among Asians; therefore, the aim of this study was to acquire insight from Chinese females' subjective perspectives. METHODS: A total of 12 semi-structured in-depth interviews, with 11 female BRCA1/BRCA 2 mutated gene carriers and 1 non-carrier with a history of one-sided breast cancer and genetic testing performed by the Hong Kong Hereditary Breast Cancer Family Registry, who subsequently underwent CPM, were assessed using thematic analysis and a Stage Conceptual Model. Breast cancer history, procedures conducted, cosmetic satisfaction, pain, body image and sexuality issues, and cancer risk perception were discussed. Retrieval of medical records using a prospective database was also performed. RESULTS: All participants opted for prophylaxis due to their reservations concerning the efficacy of surveillance and worries of recurrent breast cancer risk. Most participants were satisfied with the overall results and their decision. One-fourth expressed different extents of regrets. Psychological relief and decreased breast cancer risk were stated as major benefits. Spouses' reactions and support were crucial for post-surgery sexual satisfaction and long-term adjustment. CONCLUSIONS: Our findings indicate that thorough education on cancer risk and realistic expectations of surgery outcomes are crucial for positive adjustment after CPM. Appropriate genetic counseling and pre-and post-surgery psychological counseling were necessary. This study adds valuable contextual insights into the experiences of living with breast cancer fear and the importance of involving spouses when counseling these patients.
DescriptionResearch Communication
Persistent Identifierhttp://hdl.handle.net/10722/159956
ISSN
2014 Impact Factor: 2.514
2015 SCImago Journal Rankings: 0.813
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, Aen_US
dc.contributor.authorChu, ATWen_US
dc.date.accessioned2012-08-16T05:59:46Z-
dc.date.available2012-08-16T05:59:46Z-
dc.date.issued2012en_US
dc.identifier.citationAsian Pacific Journal of Cancer Prevention, 2012, v. 13 n. 5, p. 2241-2247en_US
dc.identifier.issn1513-7368-
dc.identifier.urihttp://hdl.handle.net/10722/159956-
dc.descriptionResearch Communication-
dc.description.abstractOBJECTIVE: This qualitative study retrospectively examined the experience and psychological impact of contralateral prophylactic mastectomy (CPM) among Southern Chinese females with unilateral breast cancer history who underwent BRCA1/2 genetic testing. Limited knowledge is available on this topic especially among Asians; therefore, the aim of this study was to acquire insight from Chinese females' subjective perspectives. METHODS: A total of 12 semi-structured in-depth interviews, with 11 female BRCA1/BRCA 2 mutated gene carriers and 1 non-carrier with a history of one-sided breast cancer and genetic testing performed by the Hong Kong Hereditary Breast Cancer Family Registry, who subsequently underwent CPM, were assessed using thematic analysis and a Stage Conceptual Model. Breast cancer history, procedures conducted, cosmetic satisfaction, pain, body image and sexuality issues, and cancer risk perception were discussed. Retrieval of medical records using a prospective database was also performed. RESULTS: All participants opted for prophylaxis due to their reservations concerning the efficacy of surveillance and worries of recurrent breast cancer risk. Most participants were satisfied with the overall results and their decision. One-fourth expressed different extents of regrets. Psychological relief and decreased breast cancer risk were stated as major benefits. Spouses' reactions and support were crucial for post-surgery sexual satisfaction and long-term adjustment. CONCLUSIONS: Our findings indicate that thorough education on cancer risk and realistic expectations of surgery outcomes are crucial for positive adjustment after CPM. Appropriate genetic counseling and pre-and post-surgery psychological counseling were necessary. This study adds valuable contextual insights into the experiences of living with breast cancer fear and the importance of involving spouses when counseling these patients.-
dc.languageengen_US
dc.publisherAsian Pacific Organization for Cancer Prevention. The Journal's web site is located at http://www.apocp.orgen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.subjectBreast and ovarian cancer-
dc.subjectQualitative-
dc.subjectProphylactic mastectomy-
dc.subjectBRCA1 and BRCA2-
dc.subjectGenetic testing-
dc.subject.meshBRCA1 Protein - genetics-
dc.subject.meshBreast Neoplasms - genetics - mortality - psychology - surgery-
dc.subject.meshChoice Behavior-
dc.subject.meshGenetic Testing - utilization-
dc.subject.meshMastectomy - mortality-
dc.subject.meshBRCA2 Protein - genetics-
dc.subject.meshDecision Making-
dc.titleWhat made her give up her breasts: a qualitative study on decisional considerations for contralateral prophylactic mastectomy among breast cancer survivors undergoing BRCA1/2 genetic testingen_US
dc.typeArticleen_US
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_US
dc.identifier.emailChu, ATW: atwchu@hkucc.hku.hken_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.7314/APJCP.2012.13.5.2241-
dc.identifier.pmid22901201-
dc.identifier.scopuseid_2-s2.0-84872677040-
dc.identifier.hkuros205583en_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.spage2241-
dc.identifier.epage2247-
dc.identifier.isiWOS:000309470100093-
dc.publisher.placeThailand-

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