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Article: Bile duct anastomotic stricture after pediatric living donor liver transplantation

TitleBile duct anastomotic stricture after pediatric living donor liver transplantation
Authors
KeywordsAlagille syndrome
Bile duct atresia
Bile duct obstruction
Bile duct reconstruction
Bile leakage
Issue Date2012
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal of Pediatric Surgery, 2012, v. 47 n. 7, p. 1399-1403 How to Cite?
Abstract
BACKGROUND/PURPOSE: Hepaticojejunostomy is a well-accepted method, whereas duct-to-duct anastomosis is gaining popularity for bile duct reconstruction in pediatric living donor liver transplantation (LDLT). Biliary complications, especially biliary anastomotic stricture (BAS), are not clearly defined. The aim of the present study is to determine the rate of BAS and its associated risk factors. METHODS: The study included 78 pediatric patients (<18 years old) who underwent LDLT during the period from end of September 1993 to end of November 2010. The diagnosis of BAS was based on clinical, biochemical, histologic, and radiologic results. RESULTS: All patients received left-side grafts. Thirteen patients (16.7%) developed BAS after LDLT. Among them, 3 patients (23.1%) had duct-to-duct anastomosis during LDLT. The median follow-up period for the BAS group and the non-BAS group was 57.8 and 79.5 months, respectively (P = .683). Ten of the patients with BAS required percutaneous transhepatic biliary drainage with or without dilatation for treating the stricture. Multivariable analysis showed that hepatic artery thrombosis and duct-to-duct anastomosis were 2 risk factors associated with BAS. CONCLUSION: In pediatric LDLT, hepaticojejunostomy is the preferred method for bile duct reconstruction, but more large-scale research needs to be done to reconfirm this result.
Persistent Identifierhttp://hdl.handle.net/10722/159954
ISSN
2013 Impact Factor: 1.311
2013 SCImago Journal Rankings: 0.811
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorChan, SCen_HK
dc.contributor.authorChan, KLen_HK
dc.contributor.authorSharr, WWen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorLo, CMen_HK
dc.date.accessioned2012-08-16T05:59:45Z-
dc.date.available2012-08-16T05:59:45Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal of Pediatric Surgery, 2012, v. 47 n. 7, p. 1399-1403en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159954-
dc.description.abstractBACKGROUND/PURPOSE: Hepaticojejunostomy is a well-accepted method, whereas duct-to-duct anastomosis is gaining popularity for bile duct reconstruction in pediatric living donor liver transplantation (LDLT). Biliary complications, especially biliary anastomotic stricture (BAS), are not clearly defined. The aim of the present study is to determine the rate of BAS and its associated risk factors. METHODS: The study included 78 pediatric patients (<18 years old) who underwent LDLT during the period from end of September 1993 to end of November 2010. The diagnosis of BAS was based on clinical, biochemical, histologic, and radiologic results. RESULTS: All patients received left-side grafts. Thirteen patients (16.7%) developed BAS after LDLT. Among them, 3 patients (23.1%) had duct-to-duct anastomosis during LDLT. The median follow-up period for the BAS group and the non-BAS group was 57.8 and 79.5 months, respectively (P = .683). Ten of the patients with BAS required percutaneous transhepatic biliary drainage with or without dilatation for treating the stricture. Multivariable analysis showed that hepatic artery thrombosis and duct-to-duct anastomosis were 2 risk factors associated with BAS. CONCLUSION: In pediatric LDLT, hepaticojejunostomy is the preferred method for bile duct reconstruction, but more large-scale research needs to be done to reconfirm this result.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.subjectAlagille syndromeen_HK
dc.subjectBile duct atresiaen_HK
dc.subjectBile duct obstructionen_HK
dc.subjectBile duct reconstructionen_HK
dc.subjectBile leakageen_HK
dc.titleBile duct anastomotic stricture after pediatric living donor liver transplantationen_HK
dc.typeArticleen_HK
dc.identifier.emailChok, KSH: kennethchok@yahoo.com.hken_HK
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_HK
dc.identifier.emailChan, KL: klchan@hkucc.hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityChan, SC=rp01568en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpedsurg.2011.12.014en_HK
dc.identifier.pmid22813803-
dc.identifier.scopuseid_2-s2.0-84864121793en_HK
dc.identifier.hkuros205089en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864121793&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1399en_HK
dc.identifier.epage1403en_HK
dc.identifier.isiWOS:000306523300023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLo, CM=55261732500en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridSharr, WW=36864499000en_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK
dc.identifier.scopusauthoridChan, SC=7404255575en_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK

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