Article: Bile duct anastomotic stricture after pediatric living donor liver transplantation

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TitleBile duct anastomotic stricture after pediatric living donor liver transplantation
AuthorsChok, KSH1
Chan, SC1
Chan, KL1
Sharr, WW1
Tam, PKH1
Fan, ST1
Lo, CM1
KeywordsAlagille syndrome
Bile duct atresia
Bile duct obstruction
Bile duct reconstruction
Bile leakage
Issue Date2012
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
CitationJournal of Pediatric Surgery, 2012, v. 47 n. 7, p. 1399-1403 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpedsurg.2011.12.014
AbstractBACKGROUND/PURPOSE: Hepaticojejunostomy is a well-accepted method, whereas duct-to-duct anastomosis is gaining popularity for bile duct reconstruction in pediatric living donor liver transplantation (LDLT). Biliary complications, especially biliary anastomotic stricture (BAS), are not clearly defined. The aim of the present study is to determine the rate of BAS and its associated risk factors. METHODS: The study included 78 pediatric patients (<18 years old) who underwent LDLT during the period from end of September 1993 to end of November 2010. The diagnosis of BAS was based on clinical, biochemical, histologic, and radiologic results. RESULTS: All patients received left-side grafts. Thirteen patients (16.7%) developed BAS after LDLT. Among them, 3 patients (23.1%) had duct-to-duct anastomosis during LDLT. The median follow-up period for the BAS group and the non-BAS group was 57.8 and 79.5 months, respectively (P = .683). Ten of the patients with BAS required percutaneous transhepatic biliary drainage with or without dilatation for treating the stricture. Multivariable analysis showed that hepatic artery thrombosis and duct-to-duct anastomosis were 2 risk factors associated with BAS. CONCLUSION: In pediatric LDLT, hepaticojejunostomy is the preferred method for bile duct reconstruction, but more large-scale research needs to be done to reconfirm this result.
ISSN0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
DOIhttp://dx.doi.org/10.1016/j.jpedsurg.2011.12.014
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChok, KSH
dc.contributor.authorChan, SC
dc.contributor.authorChan, KL
dc.contributor.authorSharr, WW
dc.contributor.authorTam, PKH
dc.contributor.authorFan, ST
dc.contributor.authorLo, CM
dc.date.accessioned2012-08-16T05:59:45Z
dc.date.available2012-08-16T05:59:45Z
dc.date.issued2012
dc.description.abstractBACKGROUND/PURPOSE: Hepaticojejunostomy is a well-accepted method, whereas duct-to-duct anastomosis is gaining popularity for bile duct reconstruction in pediatric living donor liver transplantation (LDLT). Biliary complications, especially biliary anastomotic stricture (BAS), are not clearly defined. The aim of the present study is to determine the rate of BAS and its associated risk factors. METHODS: The study included 78 pediatric patients (<18 years old) who underwent LDLT during the period from end of September 1993 to end of November 2010. The diagnosis of BAS was based on clinical, biochemical, histologic, and radiologic results. RESULTS: All patients received left-side grafts. Thirteen patients (16.7%) developed BAS after LDLT. Among them, 3 patients (23.1%) had duct-to-duct anastomosis during LDLT. The median follow-up period for the BAS group and the non-BAS group was 57.8 and 79.5 months, respectively (P = .683). Ten of the patients with BAS required percutaneous transhepatic biliary drainage with or without dilatation for treating the stricture. Multivariable analysis showed that hepatic artery thrombosis and duct-to-duct anastomosis were 2 risk factors associated with BAS. CONCLUSION: In pediatric LDLT, hepaticojejunostomy is the preferred method for bile duct reconstruction, but more large-scale research needs to be done to reconfirm this result.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal of Pediatric Surgery, 2012, v. 47 n. 7, p. 1399-1403 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpedsurg.2011.12.014
dc.identifier.doihttp://dx.doi.org/10.1016/j.jpedsurg.2011.12.014
dc.identifier.epage1403
dc.identifier.hkuros205089
dc.identifier.issn0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
dc.identifier.issue7
dc.identifier.pmid22813803
dc.identifier.scopuseid_2-s2.0-84864121793
dc.identifier.spage1399
dc.identifier.urihttp://hdl.handle.net/10722/159954
dc.identifier.volume47
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.referencesReferences in Scopus
dc.subjectAlagille syndrome
dc.subjectBile duct atresia
dc.subjectBile duct obstruction
dc.subjectBile duct reconstruction
dc.subjectBile leakage
dc.titleBile duct anastomotic stricture after pediatric living donor liver transplantation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong