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Article: Overexpression of epstein-barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma

TitleOverexpression of epstein-barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinoma
Authors
KeywordsOncogenic role
NPC screening
Nasopharyngeal carcinoma
EBV-miR-BART7
EBV
Cancer-related pathways
Issue Date2012
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/
Citation
Anticancer Research, 2012, v. 32 n. 8, p. 3201-3210 How to Cite?
AbstractAIM: To validate Epstein-Barr virus BamHI-A rightward transcript 7 microRNA (ebv-miR-BART7) expression in plasma from patients with nasopharyngeal carcinoma (NPC) and explore the oncogenic role of ebv-miR-BART7 in NPC cells. PATIENTS AND METHODS: Plasma ebv-miR-BART7 levels were measured using real-time quantitative RT-PCR. Effects on cell proliferation, invasion, migration, and resistance to cisplatin were studied on NPC cells using real-time cell analyzer. RESULTS: The plasma ebv-miR-BART7 level was significantly higher in patients with NPC in comparison with that from healthy individuals. The ebv-miR-BART7 was detectable in all the patient plasma samples and was independent of the EBV DNA level. In vitro expression of ebv-miR-BART7 enhanced proliferation, migration, and invasion of NPC cells. Furthermore, NPC cells expressing ebv-miR-BART7 were more resistant to cisplatin. High-throughput gene expression analysis suggested that ebv-miR-BART7 affects multiple cancer-related pathways. CONCLUSION: Our results indicate that plasma ebv-miR-BART7 could be used in NPC screening, especially in cases where EBV DNA is not detectable. The association of ebv-miR-BART7 with common oncogenic pathways suggests that ebv-miR-BART7 is a potential biomarker for undifferentiated NPC.
Persistent Identifierhttp://hdl.handle.net/10722/159952
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_HK
dc.contributor.authorGao, Wen_HK
dc.contributor.authorHo, WKen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorWong, STSen_HK
dc.date.accessioned2012-08-16T05:59:45Z-
dc.date.available2012-08-16T05:59:45Z-
dc.date.issued2012en_HK
dc.identifier.citationAnticancer Research, 2012, v. 32 n. 8, p. 3201-3210en_HK
dc.identifier.issn0250-7005en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159952-
dc.description.abstractAIM: To validate Epstein-Barr virus BamHI-A rightward transcript 7 microRNA (ebv-miR-BART7) expression in plasma from patients with nasopharyngeal carcinoma (NPC) and explore the oncogenic role of ebv-miR-BART7 in NPC cells. PATIENTS AND METHODS: Plasma ebv-miR-BART7 levels were measured using real-time quantitative RT-PCR. Effects on cell proliferation, invasion, migration, and resistance to cisplatin were studied on NPC cells using real-time cell analyzer. RESULTS: The plasma ebv-miR-BART7 level was significantly higher in patients with NPC in comparison with that from healthy individuals. The ebv-miR-BART7 was detectable in all the patient plasma samples and was independent of the EBV DNA level. In vitro expression of ebv-miR-BART7 enhanced proliferation, migration, and invasion of NPC cells. Furthermore, NPC cells expressing ebv-miR-BART7 were more resistant to cisplatin. High-throughput gene expression analysis suggested that ebv-miR-BART7 affects multiple cancer-related pathways. CONCLUSION: Our results indicate that plasma ebv-miR-BART7 could be used in NPC screening, especially in cases where EBV DNA is not detectable. The association of ebv-miR-BART7 with common oncogenic pathways suggests that ebv-miR-BART7 is a potential biomarker for undifferentiated NPC.en_HK
dc.languageengen_US
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at http://ar.iiarjournals.org/en_HK
dc.relation.ispartofAnticancer Researchen_HK
dc.subjectOncogenic roleen_HK
dc.subjectNPC screeningen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectEBV-miR-BART7en_HK
dc.subjectEBVen_HK
dc.subjectCancer-related pathwaysen_HK
dc.subject.meshCarcinoma - pathology - virology-
dc.subject.meshCell movement-
dc.subject.meshHerpesvirus 4, Human - genetics-
dc.subject.meshMicroRNAs - genetics-
dc.subject.meshNasopharyngeal neoplasms - pathology - virology-
dc.subject.meshCell line, Tumor-
dc.subject.meshCell proliferation-
dc.subject.meshDNA, Viral - genetics-
dc.titleOverexpression of epstein-barr virus-encoded microRNA-BART7 in undifferentiated nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, JYW: jywchan1@hku.hken_HK
dc.identifier.emailGao, W: weigao@graduate.hku.hk-
dc.identifier.emailHo, WK: wkho@hkucc.hku.hk-
dc.identifier.emailWei, WI: hrmswwi@hku.hk-
dc.identifier.emailWong, STS: thiansze@graduate.hku.hk-
dc.identifier.authorityChan, JYW=rp01314en_HK
dc.identifier.authorityWei, WI=rp00323-
dc.identifier.authorityWong, STS=rp00478-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid22843893-
dc.identifier.scopuseid_2-s2.0-84865682751en_HK
dc.identifier.hkuros204994en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865682751&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue8en_HK
dc.identifier.spage3201en_HK
dc.identifier.epage3210en_HK
dc.identifier.isiWOS:000306892700025-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridWong, TS=7403531328en_HK
dc.identifier.scopusauthoridWei, WI=55251021200en_HK
dc.identifier.scopusauthoridHo, WK=7402968844en_HK
dc.identifier.scopusauthoridGao, W=55252457300en_HK
dc.identifier.scopusauthoridChan, JYW=55270446700en_HK

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