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Article: Transplacental transfer of melamine

TitleTransplacental transfer of melamine
Authors
Partanen, HVähäkangas, KWoo, CSJAuriola, SVeid, JChen, YMyllynen, PEl Nezami, H
KeywordsCyanuric acid
Fetal exposure
Human placental perfusion
Transporters
Issue Date2012
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placenta
Citation
Placenta, 2012, v. 33 n. 1, p. 60-66 How to Cite?
DOI: http://dx.doi.org/10.1016/j.placenta.2011.10.010
AbstractObjective: To characterize transplacental transfer of melamine and related mechanisms as well as toxicity using human placental perfusion and cultured cells. Methods: Transfer and toxicity were analyzed in 4-h perfusions with 10 μM or 1 mM melamine, or 10 μM melamine with 10 nM cyanuric acid (CYA). Efflux transporters were studied in accumulation assay and toxicity in BeWo cells by MTT assay. Results: Of added melamine 34-45% was transferred to fetal circulation and CYA made no difference. Histology, hCG production, and PLAP activity indicated functionality of placental tissue with no grave toxicity. Highest concentration of melamine used (2 mM) with CYA and long treatment time decreased viability of BeWo cells. Inhibitors of ABCB1, ABCG2, ABCC2 did not affect the accumulation of melamine in cells. Conclusion: Melamine goes through human term placenta with no contribution of efflux transporters. Toxicity of melamine is low in placental tissue and BeWo cells. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/159934
ISSN
0143-4004
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.983
ISI Accession Number ID
WOS:000299582700009
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorPartanen, Hen_HK
dc.contributor.authorVähäkangas, Ken_HK
dc.contributor.authorWoo, CSJen_HK
dc.contributor.authorAuriola, Sen_HK
dc.contributor.authorVeid, Jen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorMyllynen, Pen_HK
dc.contributor.authorEl Nezami, Hen_HK
dc.date.accessioned2012-08-16T05:59:39Z-
dc.date.available2012-08-16T05:59:39Z-
dc.date.issued2012en_HK
dc.identifier.citationPlacenta, 2012, v. 33 n. 1, p. 60-66en_HK
dc.identifier.issn0143-4004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159934-
dc.description.abstractObjective: To characterize transplacental transfer of melamine and related mechanisms as well as toxicity using human placental perfusion and cultured cells. Methods: Transfer and toxicity were analyzed in 4-h perfusions with 10 μM or 1 mM melamine, or 10 μM melamine with 10 nM cyanuric acid (CYA). Efflux transporters were studied in accumulation assay and toxicity in BeWo cells by MTT assay. Results: Of added melamine 34-45% was transferred to fetal circulation and CYA made no difference. Histology, hCG production, and PLAP activity indicated functionality of placental tissue with no grave toxicity. Highest concentration of melamine used (2 mM) with CYA and long treatment time decreased viability of BeWo cells. Inhibitors of ABCB1, ABCG2, ABCC2 did not affect the accumulation of melamine in cells. Conclusion: Melamine goes through human term placenta with no contribution of efflux transporters. Toxicity of melamine is low in placental tissue and BeWo cells. © 2011 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placentaen_HK
dc.relation.ispartofPlacentaen_HK
dc.subjectCyanuric acid-
dc.subjectFetal exposure-
dc.subjectHuman placental perfusion-
dc.subjectTransporters-
dc.subject.meshATP-Binding Cassette Transporters - antagonists & inhibitorsen_HK
dc.subject.meshBiological Transport - drug effectsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshChorionic Gonadotropin - secretionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMaternal-Fetal Exchange - drug effectsen_HK
dc.subject.meshMembrane Transport Modulators - pharmacologyen_HK
dc.subject.meshMultidrug Resistance-Associated Proteins - antagonists & inhibitorsen_HK
dc.subject.meshNeoplasm Proteins - antagonists & inhibitorsen_HK
dc.subject.meshP-Glycoprotein - antagonists & inhibitorsen_HK
dc.subject.meshPerfusion - methodsen_HK
dc.subject.meshPlacenta - blood supply - cytology - drug effects - physiologyen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Proteins - antagonists & inhibitors - metabolism - secretionen_HK
dc.subject.meshResins, Synthetic - metabolism - toxicityen_HK
dc.subject.meshTriazines - metabolism - pharmacology - toxicityen_HK
dc.subject.meshTrophoblasts - cytology - drug effects - metabolismen_HK
dc.titleTransplacental transfer of melamineen_HK
dc.typeArticleen_HK
dc.identifier.emailEl Nezami, H: elnezami@hkucc.hku.hken_HK
dc.identifier.authorityEl Nezami, H=rp00694en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.placenta.2011.10.010en_HK
dc.identifier.pmid22082655-
dc.identifier.scopuseid_2-s2.0-84655169780en_HK
dc.identifier.hkuros203969en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84655169780&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue1en_HK
dc.identifier.spage60en_HK
dc.identifier.epage66en_HK
dc.identifier.eissn1532-3102-
dc.identifier.isiWOS:000299582700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPartanen, H=35201638100en_HK
dc.identifier.scopusauthoridVähäkangas, K=7004284731en_HK
dc.identifier.scopusauthoridWoo, CSJ=54384477300en_HK
dc.identifier.scopusauthoridAuriola, S=7003495721en_HK
dc.identifier.scopusauthoridVeid, J=41961697200en_HK
dc.identifier.scopusauthoridChen, Y=54796389200en_HK
dc.identifier.scopusauthoridMyllynen, P=7004099488en_HK
dc.identifier.scopusauthoridEl Nezami, H=6603690577en_HK
dc.identifier.issnl0143-4004-

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