Article: Effects of water uptake on melamine renal stone formation in mice

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TitleEffects of water uptake on melamine renal stone formation in mice
AuthorsPeng, J1
Li, D1
Chan, YK2
Chen, Y1
Lamb, JR3
Tam, PKH1
ElNezami, H2
KeywordsMacrophage
Melamine renal stone
Mouse
Osteopontin
Water ingestion
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
CitationNephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ndt/gfr577
AbstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.
ISSN0931-0509
2011 Impact Factor: 3.396
2011 SCImago Journal Rankings: 0.277
DOIhttp://dx.doi.org/10.1093/ndt/gfr577
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorPeng, J
dc.contributor.authorLi, D
dc.contributor.authorChan, YK
dc.contributor.authorChen, Y
dc.contributor.authorLamb, JR
dc.contributor.authorTam, PKH
dc.contributor.authorElNezami, H
dc.date.accessioned2012-08-16T05:59:38Z
dc.date.available2012-08-16T05:59:38Z
dc.date.issued2012
dc.description.abstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ndt/gfr577
dc.identifier.doihttp://dx.doi.org/10.1093/ndt/gfr577
dc.identifier.epage2231
dc.identifier.hkuros203963
dc.identifier.issn0931-0509
2011 Impact Factor: 3.396
2011 SCImago Journal Rankings: 0.277
dc.identifier.issue6
dc.identifier.pmid21987538
dc.identifier.scopuseid_2-s2.0-84861867891
dc.identifier.spage2225
dc.identifier.urihttp://hdl.handle.net/10722/159933
dc.identifier.volume27
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofNephrology Dialysis Transplantation
dc.relation.referencesReferences in Scopus
dc.subject.meshAcute-Phase Proteins - genetics - metabolism
dc.subject.meshAnimals
dc.subject.meshBody Weight - drug effects
dc.subject.meshCreatinine - blood
dc.subject.meshDrinking Water - administration & dosage
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshKidney Calculi - chemically induced - prevention & control
dc.subject.meshLipocalins - genetics - metabolism
dc.subject.meshMembrane Proteins - genetics - metabolism
dc.subject.meshMice
dc.subject.meshMice, Inbred C57BL
dc.subject.meshOncogene Proteins - genetics - metabolism
dc.subject.meshOsteopontin - genetics - metabolism
dc.subject.meshRNA, Messenger - genetics
dc.subject.meshReal-Time Polymerase Chain Reaction
dc.subject.meshResins, Synthetic - toxicity
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
dc.subject.meshTriazines - toxicity
dc.subject.meshUrea - blood
dc.subjectMacrophage
dc.subjectMelamine renal stone
dc.subjectMouse
dc.subjectOsteopontin
dc.subjectWater ingestion
dc.titleEffects of water uptake on melamine renal stone formation in mice
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Imperial College London