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Article: Effects of water uptake on melamine renal stone formation in mice
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TitleEffects of water uptake on melamine renal stone formation in mice
 
AuthorsPeng, J1
Li, D1
Chan, YK2
Chen, Y1
Lamb, JR3
Tam, PKH1
El-Nezami, H2
 
KeywordsMacrophage
Melamine renal stone
Mouse
Osteopontin
Water ingestion
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
 
CitationNephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ndt/gfr577
 
AbstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.
 
ISSN0931-0509
2012 Impact Factor: 3.371
2012 SCImago Journal Rankings: 1.426
 
DOIhttp://dx.doi.org/10.1093/ndt/gfr577
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorPeng, J
 
dc.contributor.authorLi, D
 
dc.contributor.authorChan, YK
 
dc.contributor.authorChen, Y
 
dc.contributor.authorLamb, JR
 
dc.contributor.authorTam, PKH
 
dc.contributor.authorEl-Nezami, H
 
dc.date.accessioned2012-08-16T05:59:38Z
 
dc.date.available2012-08-16T05:59:38Z
 
dc.date.issued2012
 
dc.description.abstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationNephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ndt/gfr577
 
dc.identifier.doihttp://dx.doi.org/10.1093/ndt/gfr577
 
dc.identifier.eissn1460-2385
 
dc.identifier.epage2231
 
dc.identifier.hkuros203963
 
dc.identifier.hkuros213442
 
dc.identifier.issn0931-0509
2012 Impact Factor: 3.371
2012 SCImago Journal Rankings: 1.426
 
dc.identifier.issue6
 
dc.identifier.pmid21987538
 
dc.identifier.scopuseid_2-s2.0-84861867891
 
dc.identifier.spage2225
 
dc.identifier.urihttp://hdl.handle.net/10722/159933
 
dc.identifier.volume27
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofNephrology Dialysis Transplantation
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAcute-Phase Proteins - genetics - metabolism
 
dc.subject.meshAnimals
 
dc.subject.meshBody Weight - drug effects
 
dc.subject.meshCreatinine - blood
 
dc.subject.meshDrinking Water - administration & dosage
 
dc.subject.meshImmunoenzyme Techniques
 
dc.subject.meshKidney Calculi - chemically induced - prevention & control
 
dc.subject.meshLipocalins - genetics - metabolism
 
dc.subject.meshMembrane Proteins - genetics - metabolism
 
dc.subject.meshMice
 
dc.subject.meshMice, Inbred C57BL
 
dc.subject.meshOncogene Proteins - genetics - metabolism
 
dc.subject.meshOsteopontin - genetics - metabolism
 
dc.subject.meshRNA, Messenger - genetics
 
dc.subject.meshReal-Time Polymerase Chain Reaction
 
dc.subject.meshResins, Synthetic - toxicity
 
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction
 
dc.subject.meshTriazines - toxicity
 
dc.subject.meshUrea - blood
 
dc.subjectMacrophage
 
dc.subjectMelamine renal stone
 
dc.subjectMouse
 
dc.subjectOsteopontin
 
dc.subjectWater ingestion
 
dc.titleEffects of water uptake on melamine renal stone formation in mice
 
dc.typeArticle
 
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<contributor.author>Lamb, JR</contributor.author>
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<description.abstract>Background. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. &#169; 2012 The Author.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Imperial College London