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Article: Effects of water uptake on melamine renal stone formation in mice

TitleEffects of water uptake on melamine renal stone formation in mice
Authors
KeywordsMacrophage
Melamine renal stone
Mouse
Osteopontin
Water ingestion
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231 How to Cite?
AbstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/159933
ISSN
2014 Impact Factor: 3.577
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPeng, Jen_HK
dc.contributor.authorLi, Den_HK
dc.contributor.authorChan, YKen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorLamb, JRen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorEl-Nezami, Hen_HK
dc.date.accessioned2012-08-16T05:59:38Z-
dc.date.available2012-08-16T05:59:38Z-
dc.date.issued2012en_HK
dc.identifier.citationNephrology Dialysis Transplantation, 2012, v. 27 n. 6, p. 2225-2231en_HK
dc.identifier.issn0931-0509en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159933-
dc.description.abstractBackground. Melamine-tainted food can induce kidney stones both in humans and animals and in domestic animals, severe cases caused acute kidney failure and death. Although increasing water intake can ameliorate kidney stone formation, its effect on melamine (Mel)-induced kidney stones has not been studied.Methods.We have analysed the effect of restricted ingestion of drinking water on melamine stone formation in mice. They were given melamine and cyanuric acid orally and received drinking water either freely or for a restricted time. Kidney stone formation and renal function were monitored.Results.Mice receiving drinking water for a restricted 10-h period initially lost body weight, which returned to normal within 2 days. No other abnormalities were observed. Ingestion of melamine alone failed to induce kidney stones even under conditions of restricted drinking water. In mice treated with melamine together with cyanuric acid for 3 days, no renal stones were formed when the supply of drinking was normal. However, when drinking water was limited, stone formation was observed and accompanied by high levels of serum urea and creatinine. An increase in urine haemoglobin and glucose levels was also found. The administration resulted in up-regulated tissue osteopontin, kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin messenger RNA expression and macrophage infiltration.Conclusions.Our results indicate the importance of water intake in the formation of melamine-induced renal stone formation in the mouse and provide new information on the mechanisms of melamine stone formation. © 2012 The Author.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_HK
dc.relation.ispartofNephrology Dialysis Transplantationen_HK
dc.subjectMacrophageen_HK
dc.subjectMelamine renal stoneen_HK
dc.subjectMouseen_HK
dc.subjectOsteopontinen_HK
dc.subjectWater ingestionen_HK
dc.subject.meshAcute-Phase Proteins - genetics - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBody Weight - drug effectsen_HK
dc.subject.meshCreatinine - blooden_HK
dc.subject.meshDrinking Water - administration & dosageen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshKidney Calculi - chemically induced - prevention & controlen_HK
dc.subject.meshLipocalins - genetics - metabolismen_HK
dc.subject.meshMembrane Proteins - genetics - metabolismen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshOncogene Proteins - genetics - metabolismen_HK
dc.subject.meshOsteopontin - genetics - metabolismen_HK
dc.subject.meshRNA, Messenger - geneticsen_HK
dc.subject.meshReal-Time Polymerase Chain Reactionen_HK
dc.subject.meshResins, Synthetic - toxicityen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTriazines - toxicityen_HK
dc.subject.meshUrea - blooden_HK
dc.titleEffects of water uptake on melamine renal stone formation in miceen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y: ychenc@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.emailEl-Nezami, H: elnezami@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp01318en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityEl-Nezami, H=rp00694en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ndt/gfr577en_HK
dc.identifier.pmid21987538en_HK
dc.identifier.scopuseid_2-s2.0-84861867891en_HK
dc.identifier.hkuros203963en_US
dc.identifier.hkuros213442-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861867891&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2225en_HK
dc.identifier.epage2231en_HK
dc.identifier.eissn1460-2385-
dc.identifier.isiWOS:000304832100018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPeng, J=49961959700en_HK
dc.identifier.scopusauthoridLi, D=53264079000en_HK
dc.identifier.scopusauthoridChan, YK=55242314700en_HK
dc.identifier.scopusauthoridChen, Y=36463185300en_HK
dc.identifier.scopusauthoridLamb, JR=7201524642en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK
dc.identifier.scopusauthoridElNezami, H=6603690577en_HK

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