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Article: Population pharmacokinetics of alcohol on Chinese subjects using breath measures

TitlePopulation pharmacokinetics of alcohol on Chinese subjects using breath measures
Authors
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal is located at http://www.wiley.com/bw/journal.asp?ref=0269-4727
Citation
Journal Of Clinical Pharmacy And Therapeutics, 2011, v. 36 n. 6, p. 716-724 How to Cite?
AbstractSummary What is known and Objective: Alcohol is a widely used drug. Our objective was to examine alcohol pharmacokinetics in Chinese subjects through the breath measurement of blood alcohol concentration (BAC) to identify any measurable covariates that may help explain variability between subjects. Methods: Breath-alcohol measurements of 184 healthy Chinese subjects were collected. Compartmental models including one- and two-compartment process were examined. First-order kinetics was applied to model alcohol absorption and elimination phases. For the sake of simplicity, only the subject's body weight, sex and stomach condition were investigated as covariates in our random effects modelling. Results and Discussion: The body as a whole behaves as a single compartment, with the suggested one-compartment model being good enough to characterize the biological process. In line with other studies, food ingestion before/with the dose slowed down alcohol absorption into the central compartment. Female subjects exhibited a significantly higher BAC elimination rate than that of males. Body weight also contributed to the observed inter-subject variability in alcohol clearance. What is new and Conclusion: We present a model for estimating blood-alcohol levels from breath-alcohol measurements. The results of our study are useful particularly in relation to drink-driving prosecutions because of the routine use of breath-alcohol measurements as evidence in such cases through the world. © 2010 The Authors. JCPT © 2010 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/159906
ISSN
2015 Impact Factor: 1.833
2015 SCImago Journal Rankings: 0.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, CTen_HK
dc.contributor.authorFung, WKen_HK
dc.contributor.authorTam, TWMen_HK
dc.date.accessioned2012-08-16T05:59:10Z-
dc.date.available2012-08-16T05:59:10Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Clinical Pharmacy And Therapeutics, 2011, v. 36 n. 6, p. 716-724en_HK
dc.identifier.issn0269-4727en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159906-
dc.description.abstractSummary What is known and Objective: Alcohol is a widely used drug. Our objective was to examine alcohol pharmacokinetics in Chinese subjects through the breath measurement of blood alcohol concentration (BAC) to identify any measurable covariates that may help explain variability between subjects. Methods: Breath-alcohol measurements of 184 healthy Chinese subjects were collected. Compartmental models including one- and two-compartment process were examined. First-order kinetics was applied to model alcohol absorption and elimination phases. For the sake of simplicity, only the subject's body weight, sex and stomach condition were investigated as covariates in our random effects modelling. Results and Discussion: The body as a whole behaves as a single compartment, with the suggested one-compartment model being good enough to characterize the biological process. In line with other studies, food ingestion before/with the dose slowed down alcohol absorption into the central compartment. Female subjects exhibited a significantly higher BAC elimination rate than that of males. Body weight also contributed to the observed inter-subject variability in alcohol clearance. What is new and Conclusion: We present a model for estimating blood-alcohol levels from breath-alcohol measurements. The results of our study are useful particularly in relation to drink-driving prosecutions because of the routine use of breath-alcohol measurements as evidence in such cases through the world. © 2010 The Authors. JCPT © 2010 Blackwell Publishing Ltd.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal is located at http://www.wiley.com/bw/journal.asp?ref=0269-4727en_US
dc.relation.ispartofJournal of Clinical Pharmacy and Therapeuticsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_US
dc.subject.meshAlcohol Drinking - blooden_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBody Weighten_HK
dc.subject.meshBreath Testsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshEthanol - pharmacokineticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshSex Factorsen_HK
dc.titlePopulation pharmacokinetics of alcohol on Chinese subjects using breath measuresen_HK
dc.typeArticleen_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2710.2010.01226.xen_HK
dc.identifier.pmid21143613-
dc.identifier.scopuseid_2-s2.0-80055053099en_HK
dc.identifier.hkuros203735en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055053099&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue6en_HK
dc.identifier.spage716en_HK
dc.identifier.epage724en_HK
dc.identifier.isiWOS:000297023500011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYang, CT=54394863200en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.scopusauthoridTam, TWM=7102012763en_HK

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