File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Detection of parent-of-origin effects for quantitative traits in complete and incomplete nuclear families with multiple children

TitleDetection of parent-of-origin effects for quantitative traits in complete and incomplete nuclear families with multiple children
Authors
Keywordsgenomic imprinting
quantitative trait loci
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
Citation
American Journal Of Epidemiology, 2011, v. 174 n. 2, p. 226-233 How to Cite?
AbstractFor a diallelic genetic marker locus, tests like the parental-asymmetry test (PAT) are simple and powerful for detecting parent-of-origin effects. However, these approaches are applicable only to qualitative traits and thus are currently not suitable for quantitative traits. In this paper, the authors propose a novel class of PAT-type parent-of-origin effects tests for quantitative traits in families with both parents and an arbitrary number of children, which is denoted by Q-PAT(c) for some constant c. The authors further develop Q-1-PAT(c) for detection of parent-of-origin effects when information is available on only 1 parent in each family. The authors suggest the Q-C-PAT(c) test for combining families with data on both parental genotypes and families with data on only 1 parental genotype. Simulation studies show that the proposed tests control the empirical type I error rates well under the null hypothesis of no parent-of-origin effects. Power comparison also demonstrates that the proposed methods are more powerful than the existing likelihood ratio test. Although normality is commonly assumed in methods for studying quantitative traits, the tests proposed in this paper do not make any assumption about the distribution of the quantitative trait. © 2011 The Author.
Persistent Identifierhttp://hdl.handle.net/10722/159905
ISSN
2015 Impact Factor: 5.036
2015 SCImago Journal Rankings: 3.047
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHe, Fen_HK
dc.contributor.authorZhou, JYen_HK
dc.contributor.authorHu, YQen_HK
dc.contributor.authorSun, Fen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorLin, Sen_HK
dc.contributor.authorFung, WKen_HK
dc.date.accessioned2012-08-16T05:59:10Z-
dc.date.available2012-08-16T05:59:10Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Journal Of Epidemiology, 2011, v. 174 n. 2, p. 226-233en_HK
dc.identifier.issn0002-9262en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159905-
dc.description.abstractFor a diallelic genetic marker locus, tests like the parental-asymmetry test (PAT) are simple and powerful for detecting parent-of-origin effects. However, these approaches are applicable only to qualitative traits and thus are currently not suitable for quantitative traits. In this paper, the authors propose a novel class of PAT-type parent-of-origin effects tests for quantitative traits in families with both parents and an arbitrary number of children, which is denoted by Q-PAT(c) for some constant c. The authors further develop Q-1-PAT(c) for detection of parent-of-origin effects when information is available on only 1 parent in each family. The authors suggest the Q-C-PAT(c) test for combining families with data on both parental genotypes and families with data on only 1 parental genotype. Simulation studies show that the proposed tests control the empirical type I error rates well under the null hypothesis of no parent-of-origin effects. Power comparison also demonstrates that the proposed methods are more powerful than the existing likelihood ratio test. Although normality is commonly assumed in methods for studying quantitative traits, the tests proposed in this paper do not make any assumption about the distribution of the quantitative trait. © 2011 The Author.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/en_HK
dc.relation.ispartofAmerican Journal of Epidemiologyen_HK
dc.subjectgenomic imprintingen_HK
dc.subjectquantitative trait locien_HK
dc.subject.meshGenomic Imprintingen_HK
dc.subject.meshLinkage Disequilibriumen_HK
dc.subject.meshNuclear Familyen_HK
dc.subject.meshParentsen_HK
dc.subject.meshQuantitative Trait Locien_HK
dc.titleDetection of parent-of-origin effects for quantitative traits in complete and incomplete nuclear families with multiple childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailHu, YQ: yqhu@hku.hken_HK
dc.identifier.emailFung, WK: wingfung@hku.hken_HK
dc.identifier.authorityHu, YQ=rp00708en_HK
dc.identifier.authorityFung, WK=rp00696en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/aje/kwr056en_HK
dc.identifier.pmid21633117-
dc.identifier.pmcidPMC3167678-
dc.identifier.scopuseid_2-s2.0-79960527502en_HK
dc.identifier.hkuros203706en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960527502&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume174en_HK
dc.identifier.issue2en_HK
dc.identifier.spage226en_HK
dc.identifier.epage233en_HK
dc.identifier.eissn1476-6256-
dc.identifier.isiWOS:000292778600013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHe, F=46761079700en_HK
dc.identifier.scopusauthoridZhou, JY=16240300900en_HK
dc.identifier.scopusauthoridHu, YQ=13410089000en_HK
dc.identifier.scopusauthoridSun, F=7401804190en_HK
dc.identifier.scopusauthoridYang, J=46761594400en_HK
dc.identifier.scopusauthoridLin, S=7407613676en_HK
dc.identifier.scopusauthoridFung, WK=13310399400en_HK
dc.identifier.citeulike9558522-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats