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Article: Randomized non-invasive sham-controlled pilot trial of electroacupuncture for postpartum depression

TitleRandomized non-invasive sham-controlled pilot trial of electroacupuncture for postpartum depression
Authors
KeywordsAcupuncture
Depression
Postpartum
Randomized Controlled Trial
Traditional Chinese medicine
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad
Citation
Journal Of Affective Disorders, 2012, v. 142 n. 1-3, p. 115-121 How to Cite?
AbstractBackground: Postpartum depression affects 10-15% of mothers. Although acupuncture was efficacious for major depressive disorder in pregnancy and in women outside the perinatal period, there has been no randomized controlled study on the feasibility, tolerability, and efficacy of acupuncture for postpartum depression. Methods: This was a randomized, subject- and assessor-blind, parallel-group, sham-controlled trial. Twenty women within six months postpartum with DSM-IV-diagnosed major depressive disorder of mild severity, defined as a 17-item Hamilton Depression Rating Scale (HDRS 17) score of 12 to 19, were randomly assigned to either electroacupuncture or non-invasive sham acupuncture two sessions weekly for four weeks. Results: There was significant reduction in HDRS 17 score from baseline to 4-week posttreatment in both groups, with an effect size 1.4 and 1.8 for electroacupuncture and sham acupuncture, respectively. Improvement was observed as early as two weeks after commencing acupuncture. The response and remission rate in the electroacupuncture group at 4-week posttreatment was 33% and 44%, respectively; for the sham acupuncture group, it was 60% and 50%, respectively. There was no significant between-group difference in all outcome measures, including the HDRS 17, Edinburgh Postnatal Depression Scale, Hospital Anxiety and Depression Scale, Clinical Global Impression, and Sheehan Disability Scale. Treatment credibility, success of blinding, and adverse events were similar between groups. Limitation: Small sample size and high attrition rate. No waiting list observation group. Conclusion: Both electroacupuncture and non-invasive sham acupuncture were effective for postpartum depression. Further studies utilizing larger sample size, better recruitment strategies, and home-based acupuncture treatment are warranted. Clinical trial information: Pilot Study on the Use of Acupuncture for Postpartum Depression; ClinicalTrials.gov Registration #NCT01178008; URL - http://clinicaltrials.gov/ct2/show/NCT01178008?term=postpartum+acupuncture&rank=1. © 2012 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/159819
ISSN
2015 Impact Factor: 3.57
2015 SCImago Journal Rankings: 1.927
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, KFen_HK
dc.contributor.authorYeung, WFen_HK
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorYung, KPen_HK
dc.contributor.authorMan, SCen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorLeung, TWen_HK
dc.contributor.authorLeung, KYen_HK
dc.contributor.authorZiea, ETCen_HK
dc.contributor.authorTaam Wong, Ven_HK
dc.date.accessioned2012-08-16T05:57:37Z-
dc.date.available2012-08-16T05:57:37Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Affective Disorders, 2012, v. 142 n. 1-3, p. 115-121en_HK
dc.identifier.issn0165-0327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159819-
dc.description.abstractBackground: Postpartum depression affects 10-15% of mothers. Although acupuncture was efficacious for major depressive disorder in pregnancy and in women outside the perinatal period, there has been no randomized controlled study on the feasibility, tolerability, and efficacy of acupuncture for postpartum depression. Methods: This was a randomized, subject- and assessor-blind, parallel-group, sham-controlled trial. Twenty women within six months postpartum with DSM-IV-diagnosed major depressive disorder of mild severity, defined as a 17-item Hamilton Depression Rating Scale (HDRS 17) score of 12 to 19, were randomly assigned to either electroacupuncture or non-invasive sham acupuncture two sessions weekly for four weeks. Results: There was significant reduction in HDRS 17 score from baseline to 4-week posttreatment in both groups, with an effect size 1.4 and 1.8 for electroacupuncture and sham acupuncture, respectively. Improvement was observed as early as two weeks after commencing acupuncture. The response and remission rate in the electroacupuncture group at 4-week posttreatment was 33% and 44%, respectively; for the sham acupuncture group, it was 60% and 50%, respectively. There was no significant between-group difference in all outcome measures, including the HDRS 17, Edinburgh Postnatal Depression Scale, Hospital Anxiety and Depression Scale, Clinical Global Impression, and Sheehan Disability Scale. Treatment credibility, success of blinding, and adverse events were similar between groups. Limitation: Small sample size and high attrition rate. No waiting list observation group. Conclusion: Both electroacupuncture and non-invasive sham acupuncture were effective for postpartum depression. Further studies utilizing larger sample size, better recruitment strategies, and home-based acupuncture treatment are warranted. Clinical trial information: Pilot Study on the Use of Acupuncture for Postpartum Depression; ClinicalTrials.gov Registration #NCT01178008; URL - http://clinicaltrials.gov/ct2/show/NCT01178008?term=postpartum+acupuncture&rank=1. © 2012 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jaden_HK
dc.relation.ispartofJournal of Affective Disordersen_HK
dc.subjectAcupunctureen_HK
dc.subjectDepressionen_HK
dc.subjectPostpartumen_HK
dc.subjectRandomized Controlled Trialen_HK
dc.subjectTraditional Chinese medicineen_HK
dc.titleRandomized non-invasive sham-controlled pilot trial of electroacupuncture for postpartum depressionen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, KF: kfchung@hkucc.hku.hken_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityChung, KF=rp00377en_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jad.2012.04.008en_HK
dc.identifier.pmid22840621-
dc.identifier.scopuseid_2-s2.0-84868120692en_HK
dc.identifier.hkuros204320en_US
dc.identifier.hkuros218364-
dc.identifier.volume[Epub ahead of print]en_US
dc.identifier.isiWOS:000310565900017-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChung, KF=7404086681en_HK
dc.identifier.scopusauthoridYeung, WF=24345897100en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridYung, KP=55318618000en_HK
dc.identifier.scopusauthoridMan, SC=54884459700en_HK
dc.identifier.scopusauthoridLee, CP=55214582400en_HK
dc.identifier.scopusauthoridLam, SK=36854227400en_HK
dc.identifier.scopusauthoridLeung, TW=55318271900en_HK
dc.identifier.scopusauthoridLeung, KY=8247106900en_HK
dc.identifier.scopusauthoridZiea, ETC=6507982323en_HK
dc.identifier.scopusauthoridTaam Wong, V=55286164800en_HK
dc.identifier.citeulike11636328-

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