Article: Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment

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TitleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
AuthorsLi, M3
Chen, Z3
Deng, W3
He, Z3
Wang, Q3
Jiang, L3
Ma, X3
Wang, Y3
Chua, SE2
Cheung, C2
McAlonan, GM2
Sham, PC2
Collier, DA1
Gong, Q3
Li, T3
KeywordsAntipsychotics
longitudinal
MRI scan
putamen
schizophrenia
Issue Date2012
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
CitationPsychological Medicine, 2012, v. 42 n. 7, p. 1475-1483 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291711002157
AbstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.
ISSN0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
DOIhttp://dx.doi.org/10.1017/S0033291711002157
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, M
dc.contributor.authorChen, Z
dc.contributor.authorDeng, W
dc.contributor.authorHe, Z
dc.contributor.authorWang, Q
dc.contributor.authorJiang, L
dc.contributor.authorMa, X
dc.contributor.authorWang, Y
dc.contributor.authorChua, SE
dc.contributor.authorCheung, C
dc.contributor.authorMcAlonan, GM
dc.contributor.authorSham, PC
dc.contributor.authorCollier, DA
dc.contributor.authorGong, Q
dc.contributor.authorLi, T
dc.date.accessioned2012-08-16T05:57:34Z
dc.date.available2012-08-16T05:57:34Z
dc.date.issued2012
dc.description.abstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationPsychological Medicine, 2012, v. 42 n. 7, p. 1475-1483 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291711002157
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291711002157
dc.identifier.epage1483
dc.identifier.hkuros203035
dc.identifier.issn0033-2917
2011 Impact Factor: 6.159
2011 SCImago Journal Rankings: 0.269
dc.identifier.issue7
dc.identifier.pmid22030695
dc.identifier.scopuseid_2-s2.0-84861418968
dc.identifier.spage1475
dc.identifier.urihttp://hdl.handle.net/10722/159814
dc.identifier.volume42
dc.languageeng
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
dc.publisher.placeUnited Kingdom
dc.relation.ispartofPsychological Medicine
dc.relation.referencesReferences in Scopus
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.
dc.subject.meshAntipsychotic Agents - administration and dosage - pharmacology - therapeutic use
dc.subject.meshPutamen - drug effects - pathology
dc.subject.meshSchizophrenia - drug therapy - pathology
dc.subject.meshSchizophrenic Psychology
dc.subject.meshTreatment Outcome
dc.subjectAntipsychotics
dc.subjectlongitudinal
dc.subjectMRI scan
dc.subjectputamen
dc.subjectschizophrenia
dc.titleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
dc.typeArticle
Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sichuan University