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Article: Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment

TitleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
Authors
KeywordsAntipsychotics
longitudinal
MRI scan
putamen
schizophrenia
Issue Date2012
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2012, v. 42 n. 7, p. 1475-1483 How to Cite?
AbstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/159814
ISSN
2014 Impact Factor: 5.938
2014 SCImago Journal Rankings: 2.592
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Men_HK
dc.contributor.authorChen, Zen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorHe, Zen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorJiang, Len_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorChua, SEen_HK
dc.contributor.authorCheung, Cen_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorGong, Qen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2012-08-16T05:57:34Z-
dc.date.available2012-08-16T05:57:34Z-
dc.date.issued2012en_HK
dc.identifier.citationPsychological Medicine, 2012, v. 42 n. 7, p. 1475-1483en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159814-
dc.description.abstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAntipsychoticsen_HK
dc.subjectlongitudinalen_HK
dc.subjectMRI scanen_HK
dc.subjectputamenen_HK
dc.subjectschizophreniaen_HK
dc.subject.meshAntipsychotic Agents - administration and dosage - pharmacology - therapeutic use-
dc.subject.meshPutamen - drug effects - pathology-
dc.subject.meshSchizophrenia - drug therapy - pathology-
dc.subject.meshSchizophrenic Psychology-
dc.subject.meshTreatment Outcome-
dc.titleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatmenten_HK
dc.typeArticleen_HK
dc.identifier.emailChua, SE: sechua@hku.hken_HK
dc.identifier.emailCheung, C: charlton@hkucc.hku.hken_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityChua, SE=rp00438en_HK
dc.identifier.authorityCheung, C=rp01574en_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/S0033291711002157en_HK
dc.identifier.pmid22030695-
dc.identifier.scopuseid_2-s2.0-84861418968en_HK
dc.identifier.hkuros203035en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861418968&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1475en_HK
dc.identifier.epage1483en_HK
dc.identifier.isiWOS:000304441500012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, M=52264053100en_HK
dc.identifier.scopusauthoridChen, Z=54796380100en_HK
dc.identifier.scopusauthoridDeng, W=36598255000en_HK
dc.identifier.scopusauthoridHe, Z=52263908600en_HK
dc.identifier.scopusauthoridWang, Q=54402018500en_HK
dc.identifier.scopusauthoridJiang, L=36801738800en_HK
dc.identifier.scopusauthoridMa, X=35354066000en_HK
dc.identifier.scopusauthoridWang, Y=35363144300en_HK
dc.identifier.scopusauthoridChua, SE=7201550427en_HK
dc.identifier.scopusauthoridCheung, C=7202061845en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridGong, Q=7201440871en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK

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