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Article: Volume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
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TitleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
 
AuthorsLi, M3
Chen, Z3
Deng, W3
He, Z3
Wang, Q3
Jiang, L3
Ma, X3
Wang, Y3
Chua, SE2
Cheung, C2
McAlonan, GM2
Sham, PC2
Collier, DA1
Gong, Q3
Li, T3
 
KeywordsAntipsychotics
longitudinal
MRI scan
putamen
schizophrenia
 
Issue Date2012
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
CitationPsychological Medicine, 2012, v. 42 n. 7, p. 1475-1483 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291711002157
 
AbstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.
 
ISSN0033-2917
2013 Impact Factor: 5.428
 
DOIhttp://dx.doi.org/10.1017/S0033291711002157
 
ISI Accession Number IDWOS:000304441500012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, M
 
dc.contributor.authorChen, Z
 
dc.contributor.authorDeng, W
 
dc.contributor.authorHe, Z
 
dc.contributor.authorWang, Q
 
dc.contributor.authorJiang, L
 
dc.contributor.authorMa, X
 
dc.contributor.authorWang, Y
 
dc.contributor.authorChua, SE
 
dc.contributor.authorCheung, C
 
dc.contributor.authorMcAlonan, GM
 
dc.contributor.authorSham, PC
 
dc.contributor.authorCollier, DA
 
dc.contributor.authorGong, Q
 
dc.contributor.authorLi, T
 
dc.date.accessioned2012-08-16T05:57:34Z
 
dc.date.available2012-08-16T05:57:34Z
 
dc.date.issued2012
 
dc.description.abstractBackground Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. © 2011 Cambridge University Press.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPsychological Medicine, 2012, v. 42 n. 7, p. 1475-1483 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0033291711002157
 
dc.identifier.doihttp://dx.doi.org/10.1017/S0033291711002157
 
dc.identifier.epage1483
 
dc.identifier.hkuros203035
 
dc.identifier.isiWOS:000304441500012
 
dc.identifier.issn0033-2917
2013 Impact Factor: 5.428
 
dc.identifier.issue7
 
dc.identifier.pmid22030695
 
dc.identifier.scopuseid_2-s2.0-84861418968
 
dc.identifier.spage1475
 
dc.identifier.urihttp://hdl.handle.net/10722/159814
 
dc.identifier.volume42
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPsychological Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.rightsPsychological Medicine. Copyright © Cambridge University Press.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAntipsychotic Agents - administration and dosage - pharmacology - therapeutic use
 
dc.subject.meshPutamen - drug effects - pathology
 
dc.subject.meshSchizophrenia - drug therapy - pathology
 
dc.subject.meshSchizophrenic Psychology
 
dc.subject.meshTreatment Outcome
 
dc.subjectAntipsychotics
 
dc.subjectlongitudinal
 
dc.subjectMRI scan
 
dc.subjectputamen
 
dc.subjectschizophrenia
 
dc.titleVolume increases in putamen associated with positive symptom reduction in previously drug-naive schizophrenia after 6 weeks antipsychotic treatment
 
dc.typeArticle
 
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<contributor.author>Chen, Z</contributor.author>
<contributor.author>Deng, W</contributor.author>
<contributor.author>He, Z</contributor.author>
<contributor.author>Wang, Q</contributor.author>
<contributor.author>Jiang, L</contributor.author>
<contributor.author>Ma, X</contributor.author>
<contributor.author>Wang, Y</contributor.author>
<contributor.author>Chua, SE</contributor.author>
<contributor.author>Cheung, C</contributor.author>
<contributor.author>McAlonan, GM</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Collier, DA</contributor.author>
<contributor.author>Gong, Q</contributor.author>
<contributor.author>Li, T</contributor.author>
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<description.abstract>Background Brain structure appears to alter after antipsychotic administration, but it is unknown whether these alterations are associated with improvement of psychopathology in patients with schizophrenia. In this study, the authors explore this relationship.Method Altogether, 66 first-episode, drug-naive patients with schizophrenia and 23 well-matched healthy controls underwent brain magnetic resonance imaging scans at baseline. All 23 healthy controls and 42 of the patients were rescanned after 6 weeks follow-up. The patients received regular antipsychotic treatment during the 6-week period and their psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 6 weeks. The difference in PANSS scores between baseline and 6 weeks was expressed as a ratio of the scores at baseline a- a PANSS reduction ratio. A modified tensor-based morphometry procedure was applied to analyse longitudinal images. Correlations between regional volume changes, PANSS reduction ratio and antipsychotic drug dosages were explored.Results Compared with healthy controls, there was a significant increase in grey-matter volume of the right putamen in patients after 6 weeks treatment. This volume change was positively correlated with a positive PANSS reduction score but not related to drug dosages.Conclusions Putaminal volume increased after 6 weeks antipsychotic treatment in first-episode schizophrenia. The increased volume was closely correlated with improved psychopathology, suggesting the putamen might be a biomarker to predict the treatment response in schizophrenia. &#169; 2011 Cambridge University Press.</description.abstract>
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Author Affiliations
  1. King's College London
  2. The University of Hong Kong
  3. Sichuan University