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Article: Roles of cADPR and NAADP in pancreatic cells

TitleRoles of cADPR and NAADP in pancreatic cells
Authors
KeywordsADP-ribosyl cyclase
Ca2+ signaling
cADPR
NAADP
Pancreatic acinar cell
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://abbs.oxfordjournals.org/
Citation
Acta Biochimica et Biophysica Sinica, 2012, v. 44 n. 9, p. 719-729 How to Cite?
AbstractCyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca(2+)-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca(2+) signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.
Persistent Identifierhttp://hdl.handle.net/10722/159804
ISSN
2015 Impact Factor: 2.124
2015 SCImago Journal Rankings: 0.881
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Yen_US
dc.contributor.authorGraeff, Ren_US
dc.contributor.authorLee, HCen_US
dc.date.accessioned2012-08-16T05:57:02Z-
dc.date.available2012-08-16T05:57:02Z-
dc.date.issued2012en_US
dc.identifier.citationActa Biochimica et Biophysica Sinica, 2012, v. 44 n. 9, p. 719-729en_US
dc.identifier.issn1672-9145-
dc.identifier.urihttp://hdl.handle.net/10722/159804-
dc.description.abstractCyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca(2+)-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca(2+) signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://abbs.oxfordjournals.org/-
dc.relation.ispartofActa Biochimica et Biophysica Sinicaen_US
dc.subjectADP-ribosyl cyclase-
dc.subjectCa2+ signaling-
dc.subjectcADPR-
dc.subjectNAADP-
dc.subjectPancreatic acinar cell-
dc.subject.meshCalcium - metabolism-
dc.subject.meshCyclic ADP-ribose - metabolism - physiology-
dc.subject.meshNADP - analogs and derivatives - metabolism - physiology-
dc.subject.meshPancreas - cytology - metabolism-
dc.subject.meshSecond messenger systems - physiology-
dc.titleRoles of cADPR and NAADP in pancreatic cellsen_US
dc.typeArticleen_US
dc.identifier.emailZhao, Y: yongjuan@hkucc.hku.hken_US
dc.identifier.emailGraeff, R: graeffr@hku.hken_US
dc.identifier.emailLee, HC: leehc@hku.hken_US
dc.identifier.authorityGraeff, R=rp01464en_US
dc.identifier.authorityLee, HC=rp00545en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/abbs/gms044-
dc.identifier.pmid22677461-
dc.identifier.scopuseid_2-s2.0-84865597951-
dc.identifier.hkuros202949en_US
dc.identifier.volume44-
dc.identifier.issue9-
dc.identifier.spage719-
dc.identifier.epage729-
dc.identifier.isiWOS:000308010400001-
dc.publisher.placeUnited States-

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