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Article: Discovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)

TitleDiscovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)
Authors
KeywordsFollicle-stimulating hormone (FSH)
Goldfish
Growth hormone (GH)
Luteinizing hormone (LH)
PACAP-related peptide (PRP)
Pituitary adenylate cyclase-activating polypeptide (PACAP)
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 2011, v. 173 n. 3, p. 405-410 How to Cite?
AbstractPituitary adenylate cyclase-activating polypeptide (PACAP)-related peptide (PRP) is a peptide encoded with PACAP in the same precursor protein. Non-mammalian PRPs were previously termed growth hormone-releasing hormone (GHRH)-like peptide, and was regarded as the mammalian GHRH homologue in non-mammalian vertebrates until the discovery of authentic GHRH genes in teleosts and amphibians. Although a highly specific receptor for PRP, which is lost in mammals, is present in non-mammals, a clear function of PRP in vertebrates remains unknown. Using goldfish as a model, here we show the expression of PRP and its cognate receptor in the brain-pituitary-gonadal (BPG) axis, thus suggesting a function of goldfish (gf) PRP in regulating reproduction. We found that gfPRP controls the expression of reproductive hormones in the brain, pituitary and ovary. Goldfish PRP exerts stimulatory effects on the expression of salmon gonadotropin-releasing hormone (sGnRH) in the brain, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in pituitary primary culture cells, but inhibits the expression of LH in the ovary. Using the same technique, we showed that gfPRP did not alter the mRNA level of growth hormone in the pituitary primary culture. In summary, we have discovered the first function of vertebrate PRP in regulating reproduction, which provides a new research direction in studying the neuroendocrine control of reproduction not only in teleosts, but also in other non-mammalian vertebrates. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/159803
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTam, JKVen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorCheng, CHKen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2012-08-16T05:57:02Z-
dc.date.available2012-08-16T05:57:02Z-
dc.date.issued2011en_HK
dc.identifier.citationGeneral And Comparative Endocrinology, 2011, v. 173 n. 3, p. 405-410en_HK
dc.identifier.issn0016-6480en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159803-
dc.description.abstractPituitary adenylate cyclase-activating polypeptide (PACAP)-related peptide (PRP) is a peptide encoded with PACAP in the same precursor protein. Non-mammalian PRPs were previously termed growth hormone-releasing hormone (GHRH)-like peptide, and was regarded as the mammalian GHRH homologue in non-mammalian vertebrates until the discovery of authentic GHRH genes in teleosts and amphibians. Although a highly specific receptor for PRP, which is lost in mammals, is present in non-mammals, a clear function of PRP in vertebrates remains unknown. Using goldfish as a model, here we show the expression of PRP and its cognate receptor in the brain-pituitary-gonadal (BPG) axis, thus suggesting a function of goldfish (gf) PRP in regulating reproduction. We found that gfPRP controls the expression of reproductive hormones in the brain, pituitary and ovary. Goldfish PRP exerts stimulatory effects on the expression of salmon gonadotropin-releasing hormone (sGnRH) in the brain, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in pituitary primary culture cells, but inhibits the expression of LH in the ovary. Using the same technique, we showed that gfPRP did not alter the mRNA level of growth hormone in the pituitary primary culture. In summary, we have discovered the first function of vertebrate PRP in regulating reproduction, which provides a new research direction in studying the neuroendocrine control of reproduction not only in teleosts, but also in other non-mammalian vertebrates. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_HK
dc.relation.ispartofGeneral and Comparative Endocrinologyen_HK
dc.subjectFollicle-stimulating hormone (FSH)en_HK
dc.subjectGoldfishen_HK
dc.subjectGrowth hormone (GH)en_HK
dc.subjectLuteinizing hormone (LH)en_HK
dc.subjectPACAP-related peptide (PRP)en_HK
dc.subjectPituitary adenylate cyclase-activating polypeptide (PACAP)en_HK
dc.subject.meshFish Proteins - genetics - metabolism - physiology-
dc.subject.meshGoldfish - genetics - metabolism - physiology-
dc.subject.meshPeptide Fragments - genetics - metabolism - physiology-
dc.subject.meshPituitary Adenylate Cyclase-Activating Polypeptide - genetics - metabolism - physiology-
dc.subject.meshProtein Precursors - genetics - metabolism - physiology-
dc.titleDiscovery of a new reproductive hormone in teleosts: Pituitary adenylate cyclase-activating polypeptide-related peptide (PRP)en_HK
dc.typeArticleen_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygcen.2011.06.003en_HK
dc.identifier.pmid21703272-
dc.identifier.scopuseid_2-s2.0-80052457987en_HK
dc.identifier.hkuros202445en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052457987&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume173en_HK
dc.identifier.issue3en_HK
dc.identifier.spage405en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000294978300005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTam, JKV=36830083000en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridCheng, CHK=7404798014en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.citeulike9488841-

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