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Article: Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers?

TitleDoes the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers?
Authors
Keywordsde-agglomeration
dry powder inhaler
powder aerosol
USP throat
Issue Date2012
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2012, p. 1-11 How to Cite?
AbstractPurpose: We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Methods: Aerosols emitting from a range of DPIs (Spinhaler ®, Turbuhaler ® and Osmohaler TM) and induction ports (USP throat, straight tube, Alberta idealized mouth-throat geometry (AG)) were sized by laser diffraction. Total drug recovery was obtained by HPLC and fine particle fraction computed. Air flow patterns were simulated using Computational Fluid Dynamics (CFD). Results: The straight tube did not de-agglomerate emitted powder. However, the USP throat and AG further de-agglomerated powders from the Spinhaler, but not the Turbuhaler and Osmohaler. While budesonide powder deposited similarly in all induction ports, deposition was significantly higher in the AG for both DSCG and mannitol. CFD revealed agglomerates impacting on the USP throat with higher localized velocity compared with the straight tube. CFD further showed a more complex flow pattern with high-velocity air jets in the AG, which explains the higher FPF for DSCG and the lower FPF for mannitol using the AG. Conclusion: The USP throat further de-agglomerated the emitted powder from the DPI when it did not sufficiently disperse the powder. Other tools such as laser diffraction may be used for cross-examining to avoid artifacts in the results. © 2012 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/159773
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Pen_HK
dc.contributor.authorKwok, PCLen_HK
dc.contributor.authorTong, Zen_HK
dc.contributor.authorYang, Ren_HK
dc.contributor.authorRaper, JAen_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2012-08-16T05:56:16Z-
dc.date.available2012-08-16T05:56:16Z-
dc.date.issued2012en_HK
dc.identifier.citationPharmaceutical Research, 2012, p. 1-11en_HK
dc.identifier.issn0724-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159773-
dc.description.abstractPurpose: We hypothesize that the USP induction port may de-agglomerate carrier-free powder emitting from dry powder inhalers (DPIs). Methods: Aerosols emitting from a range of DPIs (Spinhaler ®, Turbuhaler ® and Osmohaler TM) and induction ports (USP throat, straight tube, Alberta idealized mouth-throat geometry (AG)) were sized by laser diffraction. Total drug recovery was obtained by HPLC and fine particle fraction computed. Air flow patterns were simulated using Computational Fluid Dynamics (CFD). Results: The straight tube did not de-agglomerate emitted powder. However, the USP throat and AG further de-agglomerated powders from the Spinhaler, but not the Turbuhaler and Osmohaler. While budesonide powder deposited similarly in all induction ports, deposition was significantly higher in the AG for both DSCG and mannitol. CFD revealed agglomerates impacting on the USP throat with higher localized velocity compared with the straight tube. CFD further showed a more complex flow pattern with high-velocity air jets in the AG, which explains the higher FPF for DSCG and the lower FPF for mannitol using the AG. Conclusion: The USP throat further de-agglomerated the emitted powder from the DPI when it did not sufficiently disperse the powder. Other tools such as laser diffraction may be used for cross-examining to avoid artifacts in the results. © 2012 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_HK
dc.relation.ispartofPharmaceutical Researchen_HK
dc.subjectde-agglomerationen_HK
dc.subjectdry powder inhaleren_HK
dc.subjectpowder aerosolen_HK
dc.subjectUSP throaten_HK
dc.titleDoes the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers?en_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, PCL: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, PCL=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11095-012-0703-yen_HK
dc.identifier.pmid22327971-
dc.identifier.scopuseid_2-s2.0-84856781012en_HK
dc.identifier.hkuros204743en_US
dc.identifier.volume29en_US
dc.identifier.spage1en_HK
dc.identifier.epage11en_HK
dc.identifier.isiWOS:000305222000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, P=8346889100en_HK
dc.identifier.scopusauthoridKwok, PCL=12646007800en_HK
dc.identifier.scopusauthoridTong, Z=35118320100en_HK
dc.identifier.scopusauthoridYang, R=7403923760en_HK
dc.identifier.scopusauthoridRaper, JA=7102297927en_HK
dc.identifier.scopusauthoridChan, HK=54968980100en_HK
dc.identifier.citeulike10376308-

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