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Article: Constant size, variable density aerosol particles by ultrasonic spray freeze drying

TitleConstant size, variable density aerosol particles by ultrasonic spray freeze drying
Authors
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijpharm
Citation
International Journal of Pharmaceutics, 2012, v. 427 n. 2, p. 185-191 How to Cite?
AbstractThis work provides a new understanding of critical process parameters involved in the production of inhalation aerosol particles by ultrasonic spray freeze drying to enable precise control over particle size and aerodynamic properties. A series of highly porous mannitol, lysozyme, and bovine serum albumin (BSA) particles were produced, varying only the solute concentration in the liquid feed, cs, from 1 to 5 wt%. The particle sizes of mannitol, BSA, and lysozyme powders were independent of solute concentration, and depend only on the drop size produced by atomization. Both mannitol and lysozyme formulations showed a linear relationship between the computed Fine Particle Fraction (FPF) and the square root of cs, which is proportional to the particle density, ρ, given a constant particle size dg. The FPF decreased with increasing cs from 57.0% to 16.6% for mannitol and 44.5% to 17.2% for lysozyme. Due to cohesion, the BSA powder FPF measured by cascade impaction was less than 10% and independent of cs. Ultrasonic spray freeze drying enables separate control over particle size, dg, and aerodynamic size, da which has allowed us to make the first experimental demonstration of the widely accepted rule da = dg(ρ/ρo)1/2 with particles of constant dg, but variable density, ρ (ρo is unit density).
Persistent Identifierhttp://hdl.handle.net/10722/159772
ISSN
2015 Impact Factor: 3.994
2015 SCImago Journal Rankings: 1.315
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorD'Addio, SMen_HK
dc.contributor.authorChan, JGYen_HK
dc.contributor.authorKwok, PCLen_HK
dc.contributor.authorPrud'homme, RKen_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2012-08-16T05:56:15Z-
dc.date.available2012-08-16T05:56:15Z-
dc.date.issued2012en_HK
dc.identifier.citationInternational Journal of Pharmaceutics, 2012, v. 427 n. 2, p. 185-191en_HK
dc.identifier.issn0378-5173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159772-
dc.description.abstractThis work provides a new understanding of critical process parameters involved in the production of inhalation aerosol particles by ultrasonic spray freeze drying to enable precise control over particle size and aerodynamic properties. A series of highly porous mannitol, lysozyme, and bovine serum albumin (BSA) particles were produced, varying only the solute concentration in the liquid feed, cs, from 1 to 5 wt%. The particle sizes of mannitol, BSA, and lysozyme powders were independent of solute concentration, and depend only on the drop size produced by atomization. Both mannitol and lysozyme formulations showed a linear relationship between the computed Fine Particle Fraction (FPF) and the square root of cs, which is proportional to the particle density, ρ, given a constant particle size dg. The FPF decreased with increasing cs from 57.0% to 16.6% for mannitol and 44.5% to 17.2% for lysozyme. Due to cohesion, the BSA powder FPF measured by cascade impaction was less than 10% and independent of cs. Ultrasonic spray freeze drying enables separate control over particle size, dg, and aerodynamic size, da which has allowed us to make the first experimental demonstration of the widely accepted rule da = dg(ρ/ρo)1/2 with particles of constant dg, but variable density, ρ (ρo is unit density).en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijpharmen_HK
dc.relation.ispartofInternational Journal of Pharmaceuticsen_HK
dc.subject.meshFreeze Drying - methodsen_HK
dc.subject.meshAerosolsen_HK
dc.subject.meshCalorimetry, Differential Scanningen_HK
dc.subject.meshFreeze Drying - methodsen_HK
dc.subject.meshParticulate Matteren_HK
dc.subject.meshUltrasonics - methodsen_HK
dc.titleConstant size, variable density aerosol particles by ultrasonic spray freeze dryingen_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, PCL: pclkwok@hku.hken_HK
dc.identifier.emailChan, HK: kim.chan@sydney.edu.au-
dc.identifier.authorityKwok, PCL=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijpharm.2012.01.048en_HK
dc.identifier.pmid22322208-
dc.identifier.scopuseid_2-s2.0-84859106992en_HK
dc.identifier.hkuros204742en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859106992&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume427en_HK
dc.identifier.issue2en_HK
dc.identifier.spage185en_HK
dc.identifier.epage191en_HK
dc.identifier.isiWOS:000302364500006-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, HK=54986432800en_HK
dc.identifier.scopusauthoridPrud'Homme, RK=55152194200en_HK
dc.identifier.scopusauthoridKwok, PCL=12646007800en_HK
dc.identifier.scopusauthoridChan, JGY=26652516900en_HK
dc.identifier.scopusauthoridD'Addio, SM=26643763000en_HK
dc.identifier.citeulike10326239-

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