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Article: Novel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
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TitleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
 
AuthorsLiu, G3
Fan, W3
Li, L3
Chu, PK2
Yeung, KWK1
Wu, S3 2 1
Xu, Z3 2 1
 
KeywordsAmphiphilic graft copolymer
Anionic
Fluoropolymer
Micelle
Protein drug carrier
Self-assembly
 
Issue Date2012
 
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluor
 
CitationJournal Of Fluorine Chemistry, 2012, v. 141, p. 21-28 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jfluchem.2012.05.021
 
AbstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.
 
ISSN0022-1139
2013 Impact Factor: 1.952
2013 SCImago Journal Rankings: 0.865
 
DOIhttp://dx.doi.org/10.1016/j.jfluchem.2012.05.021
 
ISI Accession Number IDWOS:000308120100004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, G
 
dc.contributor.authorFan, W
 
dc.contributor.authorLi, L
 
dc.contributor.authorChu, PK
 
dc.contributor.authorYeung, KWK
 
dc.contributor.authorWu, S
 
dc.contributor.authorXu, Z
 
dc.date.accessioned2012-08-16T05:55:32Z
 
dc.date.available2012-08-16T05:55:32Z
 
dc.date.issued2012
 
dc.description.abstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Fluorine Chemistry, 2012, v. 141, p. 21-28 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jfluchem.2012.05.021
 
dc.identifier.citeulike10730433
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jfluchem.2012.05.021
 
dc.identifier.epage28
 
dc.identifier.hkuros204529
 
dc.identifier.isiWOS:000308120100004
 
dc.identifier.issn0022-1139
2013 Impact Factor: 1.952
2013 SCImago Journal Rankings: 0.865
 
dc.identifier.scopuseid_2-s2.0-84864042578
 
dc.identifier.spage21
 
dc.identifier.urihttp://hdl.handle.net/10722/159751
 
dc.identifier.volume141
 
dc.languageeng
 
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluor
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofJournal of Fluorine Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAmphiphilic graft copolymer
 
dc.subjectAnionic
 
dc.subjectFluoropolymer
 
dc.subjectMicelle
 
dc.subjectProtein drug carrier
 
dc.subjectSelf-assembly
 
dc.titleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
 
dc.typeArticle
 
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<contributor.author>Fan, W</contributor.author>
<contributor.author>Li, L</contributor.author>
<contributor.author>Chu, PK</contributor.author>
<contributor.author>Yeung, KWK</contributor.author>
<contributor.author>Wu, S</contributor.author>
<contributor.author>Xu, Z</contributor.author>
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<description.abstract>A novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. &#169; 2012 Elsevier B.V. All rights reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University