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Article: Novel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier

TitleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
Authors
KeywordsAmphiphilic graft copolymer
Anionic
Fluoropolymer
Micelle
Protein drug carrier
Self-assembly
Issue Date2012
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluor
Citation
Journal Of Fluorine Chemistry, 2012, v. 141, p. 21-28 How to Cite?
AbstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/159751
ISSN
2015 Impact Factor: 2.213
2015 SCImago Journal Rankings: 0.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Gen_HK
dc.contributor.authorFan, Wen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorChu, PKen_HK
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorWu, Sen_HK
dc.contributor.authorXu, Zen_HK
dc.date.accessioned2012-08-16T05:55:32Z-
dc.date.available2012-08-16T05:55:32Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Fluorine Chemistry, 2012, v. 141, p. 21-28en_HK
dc.identifier.issn0022-1139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159751-
dc.description.abstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluoren_HK
dc.relation.ispartofJournal of Fluorine Chemistryen_HK
dc.subjectAmphiphilic graft copolymeren_HK
dc.subjectAnionicen_HK
dc.subjectFluoropolymeren_HK
dc.subjectMicelleen_HK
dc.subjectProtein drug carrieren_HK
dc.subjectSelf-assemblyen_HK
dc.titleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrieren_HK
dc.typeArticleen_HK
dc.identifier.emailYeung, KWK:wkkyeung@hkucc.hku.hken_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jfluchem.2012.05.021en_HK
dc.identifier.scopuseid_2-s2.0-84864042578en_HK
dc.identifier.hkuros204529en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864042578&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume141en_HK
dc.identifier.spage21en_HK
dc.identifier.epage28en_HK
dc.identifier.isiWOS:000308120100004-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLiu, G=50461996200en_HK
dc.identifier.scopusauthoridFan, W=54779666300en_HK
dc.identifier.scopusauthoridLi, L=36076849300en_HK
dc.identifier.scopusauthoridChu, PK=55012538700en_HK
dc.identifier.scopusauthoridYeung, KWK=13309584700en_HK
dc.identifier.scopusauthoridWu, S=36678457200en_HK
dc.identifier.scopusauthoridXu, Z=7405427789en_HK
dc.identifier.citeulike10730433-

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