Article: Novel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier

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TitleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
AuthorsLiu, G3
Fan, W3
Li, L3
Chu, PK2
Yeung, KWK1
Wu, S1 2 3
Xu, Z1 2 3
KeywordsAmphiphilic graft copolymer
Anionic
Fluoropolymer
Micelle
Protein drug carrier
Self-assembly
Issue Date2012
PublisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluor
CitationJournal Of Fluorine Chemistry, 2012, v. 141, p. 21-28 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jfluchem.2012.05.021
AbstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.
ISSN0022-1139
2011 Impact Factor: 2.033
2011 SCImago Journal Rankings: 0.148
DOIhttp://dx.doi.org/10.1016/j.jfluchem.2012.05.021
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLiu, G
dc.contributor.authorFan, W
dc.contributor.authorLi, L
dc.contributor.authorChu, PK
dc.contributor.authorYeung, KWK
dc.contributor.authorWu, S
dc.contributor.authorXu, Z
dc.date.accessioned2012-08-16T05:55:32Z
dc.date.available2012-08-16T05:55:32Z
dc.date.issued2012
dc.description.abstractA novel series of anionic fluorine-containing amphiphilic graft copolymers, poly(hexafluorobutyl methacrylate-co-sodium 4-vinylbenzenesulfonate)-g- poly(ethylene glycol) methyl ether methacrylate [poly(HFMA-co-NaSS)-g-PEG], were prepared via the free radical copolymerization. The micellization behavior of the copolymers was studied by critical micelle concentration (CMC), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The results showed that poly(HFMA-co-NaSS)-g-PEG copolymers could self-assemble into core/shell structure micelles in aqueous solution. Afterward, the micelles stability was studied by zeta potential measurement, which demonstrated that the copolymer micelles had good stability in biological milieu. The interaction between the copolymer micelles and BSA was characterized by fluorescence spectroscopy, and the morphology of the micelles/BSA complexes was observed by TEM. The results demonstrated that the adsorption could be easily achieved between the copolymer micelles and BSA. Furthermore, the cytotoxicity was evaluated via MTT viability assay, indicating that the copolymer had low toxicity. Our study suggests that poly(HFMA-co-NaSS)-g-PEG micelles have a potential application as the protein drug carrier. © 2012 Elsevier B.V. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Fluorine Chemistry, 2012, v. 141, p. 21-28 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jfluchem.2012.05.021
dc.identifier.citeulike10730433
dc.identifier.doihttp://dx.doi.org/10.1016/j.jfluchem.2012.05.021
dc.identifier.epage28
dc.identifier.hkuros204529
dc.identifier.issn0022-1139
2011 Impact Factor: 2.033
2011 SCImago Journal Rankings: 0.148
dc.identifier.scopuseid_2-s2.0-84864042578
dc.identifier.spage21
dc.identifier.urihttp://hdl.handle.net/10722/159751
dc.identifier.volume141
dc.languageeng
dc.publisherElsevier SA. The Journal's web site is located at http://www.elsevier.com/locate/fluor
dc.publisher.placeSwitzerland
dc.relation.ispartofJournal of Fluorine Chemistry
dc.relation.referencesReferences in Scopus
dc.subjectAmphiphilic graft copolymer
dc.subjectAnionic
dc.subjectFluoropolymer
dc.subjectMicelle
dc.subjectProtein drug carrier
dc.subjectSelf-assembly
dc.titleNovel anionic fluorine-containing amphiphilic self-assembly polymer micelles for potential application in protein drug carrier
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University