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Article: Fluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release

TitleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
Authors
KeywordsControlled drug release
Core/shell
Fluorine-containing
Microgel
pH-responsive
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htm
Citation
Colloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357 How to Cite?
Abstract
A kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/159750
ISSN
2013 Impact Factor: 2.410
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University
DC FieldValueLanguage
dc.contributor.authorLiu, Gen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorXiong, Sen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorChu, PKen_HK
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorWu, Sen_HK
dc.contributor.authorXu, Zen_HK
dc.date.accessioned2012-08-16T05:55:31Z-
dc.date.available2012-08-16T05:55:31Z-
dc.date.issued2012en_HK
dc.identifier.citationColloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357en_HK
dc.identifier.issn0303-402Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/159750-
dc.description.abstractA kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htmen_HK
dc.relation.ispartofColloid and Polymer Scienceen_HK
dc.subjectControlled drug releaseen_HK
dc.subjectCore/shellen_HK
dc.subjectFluorine-containingen_HK
dc.subjectMicrogelen_HK
dc.subjectpH-responsiveen_HK
dc.titleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug releaseen_HK
dc.typeArticleen_HK
dc.identifier.emailYeung, KWK:wkkyeung@hkucc.hku.hken_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00396-011-2558-xen_HK
dc.identifier.scopuseid_2-s2.0-84857635329en_HK
dc.identifier.hkuros204527en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857635329&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume290en_HK
dc.identifier.issue4en_HK
dc.identifier.spage349en_HK
dc.identifier.epage357en_HK
dc.identifier.isiWOS:000300056100008-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLiu, G=50461996200en_HK
dc.identifier.scopusauthoridLi, X=50461681200en_HK
dc.identifier.scopusauthoridXiong, S=35207489400en_HK
dc.identifier.scopusauthoridLi, L=50461855600en_HK
dc.identifier.scopusauthoridChu, PK=36040705700en_HK
dc.identifier.scopusauthoridYeung, KWK=13309584700en_HK
dc.identifier.scopusauthoridWu, S=15125218800en_HK
dc.identifier.scopusauthoridXu, Z=12760201200en_HK
dc.identifier.citeulike10112041-

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