Article: Fluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release

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TitleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
AuthorsLiu, G3
Li, X3
Xiong, S3
Li, L3
Chu, PK2
Yeung, KWK1
Wu, S1 2 3
Xu, Z1 2 3
KeywordsControlled drug release
Core/shell
Fluorine-containing
Microgel
pH-responsive
Issue Date2012
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htm
CitationColloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00396-011-2558-x
AbstractA kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.
ISSN0303-402X
2011 Impact Factor: 2.331
2011 SCImago Journal Rankings: 0.126
DOIhttp://dx.doi.org/10.1007/s00396-011-2558-x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLiu, G
dc.contributor.authorLi, X
dc.contributor.authorXiong, S
dc.contributor.authorLi, L
dc.contributor.authorChu, PK
dc.contributor.authorYeung, KWK
dc.contributor.authorWu, S
dc.contributor.authorXu, Z
dc.date.accessioned2012-08-16T05:55:31Z
dc.date.available2012-08-16T05:55:31Z
dc.date.issued2012
dc.description.abstractA kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationColloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00396-011-2558-x
dc.identifier.citeulike10112041
dc.identifier.doihttp://dx.doi.org/10.1007/s00396-011-2558-x
dc.identifier.epage357
dc.identifier.hkuros204527
dc.identifier.issn0303-402X
2011 Impact Factor: 2.331
2011 SCImago Journal Rankings: 0.126
dc.identifier.issue4
dc.identifier.scopuseid_2-s2.0-84857635329
dc.identifier.spage349
dc.identifier.urihttp://hdl.handle.net/10722/159750
dc.identifier.volume290
dc.languageeng
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htm
dc.publisher.placeGermany
dc.relation.ispartofColloid and Polymer Science
dc.relation.referencesReferences in Scopus
dc.subjectControlled drug release
dc.subjectCore/shell
dc.subjectFluorine-containing
dc.subjectMicrogel
dc.subjectpH-responsive
dc.titleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University