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Article: Fluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
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TitleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
 
AuthorsLiu, G3
Li, X3
Xiong, S3
Li, L3
Chu, PK2
Yeung, KWK1
Wu, S3 2 1
Xu, Z3 2 1
 
KeywordsControlled drug release
Core/shell
Fluorine-containing
Microgel
pH-responsive
 
Issue Date2012
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htm
 
CitationColloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00396-011-2558-x
 
AbstractA kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.
 
ISSN0303-402X
2013 Impact Factor: 2.410
 
DOIhttp://dx.doi.org/10.1007/s00396-011-2558-x
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, G
 
dc.contributor.authorLi, X
 
dc.contributor.authorXiong, S
 
dc.contributor.authorLi, L
 
dc.contributor.authorChu, PK
 
dc.contributor.authorYeung, KWK
 
dc.contributor.authorWu, S
 
dc.contributor.authorXu, Z
 
dc.date.accessioned2012-08-16T05:55:31Z
 
dc.date.available2012-08-16T05:55:31Z
 
dc.date.issued2012
 
dc.description.abstractA kind of novel fluorine-containing pH-responsive core/shell microgels poly(DMAEMA-co-HFMA)-g-PEG were prepared via surfactant-free emulsion polymerization using water as the solvent. The well-defined chemical structure of the copolymers was characterized by FTIR, 1H-NMR, 19F-NMR, and elemental analysis. The microgel particles were studied by florescence probe technique, dynamic light scattering, and zeta potential measurement; the microgels displayed a significant pH-responsive behavior. Furthermore, the cytotoxicity assay indicated that the copolymer microgels had low toxicity, and 5-FU-loaded microgels offered a certain killing potency against cancer cells. In addition, the drug loading and in vitro drug release demonstrated that 5-FU was successfully incorporated into polymeric microgels, and the drug-loaded microgels showed a marked pH-dependent drug release behavior. This study suggests that the poly(DMAEMA-co-HFMA)-g-PEG microgels play an important role in the release mechanism stimulated by the change in the pH and have potential applications as a controlled drug release carrier. © 2011 Springer-Verlag.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationColloid And Polymer Science, 2012, v. 290 n. 4, p. 349-357 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00396-011-2558-x
 
dc.identifier.citeulike10112041
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00396-011-2558-x
 
dc.identifier.epage357
 
dc.identifier.hkuros204527
 
dc.identifier.issn0303-402X
2013 Impact Factor: 2.410
 
dc.identifier.issue4
 
dc.identifier.scopuseid_2-s2.0-84857635329
 
dc.identifier.spage349
 
dc.identifier.urihttp://hdl.handle.net/10722/159750
 
dc.identifier.volume290
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00396/index.htm
 
dc.publisher.placeGermany
 
dc.relation.ispartofColloid and Polymer Science
 
dc.relation.referencesReferences in Scopus
 
dc.subjectControlled drug release
 
dc.subjectCore/shell
 
dc.subjectFluorine-containing
 
dc.subjectMicrogel
 
dc.subjectpH-responsive
 
dc.titleFluorine-containing pH-responsive core/shell microgel particles: Preparation, characterization, and their applications in controlled drug release
 
dc.typeArticle
 
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<contributor.author>Li, L</contributor.author>
<contributor.author>Chu, PK</contributor.author>
<contributor.author>Yeung, KWK</contributor.author>
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<contributor.author>Xu, Z</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University