Article: Cationic lanthanide luminescent copolymer: Design, synthesis and interaction with DNA

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Publisher Website: 10.1080/10601325.2011.603638
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Title	Cationic lanthanide luminescent copolymer: Design, synthesis and interaction with DNA
Authors	Li, P3 Hu, X3 Wu, S2 3 Chu, PK2 Yeung, KWK1 Xu, Z2 3
Keywords	Cationic DNA lanthanide complex luminescent copolymer
Issue Date	2011
Publisher	Taylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10601325.asp
Citation	Journal Of Macromolecular Science, Part A: Pure And Applied Chemistry, 2011, v. 48 n. 10, p. 832-839 [How to Cite?] DOI: http://dx.doi.org/10.1080/10601325.2011.603638
Abstract	Polymerizable rare earth complex Eu(AA)3Phen was synthesized by complexion of europium ion, acrylic acid (AA), and 1,10-phenanthroline (Phen). The structure and fluorescence properties of the complex were studied by elemental analysis, 1H-NMR spectroscopy, and fluorescence spectroscopy. Eu-containing copolymer poly(PEGMA-co-MMA-co-METAC-co-Eu(AA)3Phen) (PPMMEu) was then synthesized by free radical copolymerization of Eu(AA)3Phen and other functional monomers including poly(ethylene glycol) methyl ether methacrylate (PEGMA) and [2-(Methacryloyloxy) ethyl] trimethylammonium chloride (METAC). 1H-NMR spectroscopy and fluorescence spectroscopy were used to characterize the copolymer and the interactions between the copolymer and DNA was investigated by TEM, fluorescence spectroscopy, and agarose gel electrophoresis. The desired luminescent cationic copolymer was successfully obtained. The copolymer can form micelles in water solution and can efficiently bind to DNA molecules through electrostatic interaction. The results suggest the potential use of PPMMEu in bioprobes and gene vectors. © 2011 Taylor & Francis Group, LLC.
ISSN	1060-1325 2011 Impact Factor: 0.887 2011 SCImago Journal Rankings: 0.057
DOI	http://dx.doi.org/10.1080/10601325.2011.603638
References	References in Scopus

DC Field	Value
dc.contributor.author	Li, P
dc.contributor.author	Hu, X
dc.contributor.author	Wu, S
dc.contributor.author	Chu, PK
dc.contributor.author	Yeung, KWK
dc.contributor.author	Xu, Z
dc.date.accessioned	2012-08-16T05:55:29Z
dc.date.available	2012-08-16T05:55:29Z
dc.date.issued	2011
dc.description.abstract	Polymerizable rare earth complex Eu(AA)3Phen was synthesized by complexion of europium ion, acrylic acid (AA), and 1,10-phenanthroline (Phen). The structure and fluorescence properties of the complex were studied by elemental analysis, 1H-NMR spectroscopy, and fluorescence spectroscopy. Eu-containing copolymer poly(PEGMA-co-MMA-co-METAC-co-Eu(AA)3Phen) (PPMMEu) was then synthesized by free radical copolymerization of Eu(AA)3Phen and other functional monomers including poly(ethylene glycol) methyl ether methacrylate (PEGMA) and [2-(Methacryloyloxy) ethyl] trimethylammonium chloride (METAC). 1H-NMR spectroscopy and fluorescence spectroscopy were used to characterize the copolymer and the interactions between the copolymer and DNA was investigated by TEM, fluorescence spectroscopy, and agarose gel electrophoresis. The desired luminescent cationic copolymer was successfully obtained. The copolymer can form micelles in water solution and can efficiently bind to DNA molecules through electrostatic interaction. The results suggest the potential use of PPMMEu in bioprobes and gene vectors. © 2011 Taylor & Francis Group, LLC.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Journal Of Macromolecular Science, Part A: Pure And Applied Chemistry, 2011, v. 48 n. 10, p. 832-839 [How to Cite?] DOI: http://dx.doi.org/10.1080/10601325.2011.603638
dc.identifier.doi	http://dx.doi.org/10.1080/10601325.2011.603638
dc.identifier.epage	839
dc.identifier.hkuros	204521
dc.identifier.issn	1060-1325 2011 Impact Factor: 0.887 2011 SCImago Journal Rankings: 0.057
dc.identifier.issue	10
dc.identifier.scopus	eid_2-s2.0-80052317101
dc.identifier.spage	832
dc.identifier.uri	http://hdl.handle.net/10722/159746
dc.identifier.volume	48
dc.language	eng
dc.publisher	Taylor & Francis Inc. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10601325.asp
dc.publisher.place	United States
dc.relation.ispartof	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
dc.relation.references	References in Scopus
dc.subject	Cationic
dc.subject	DNA
dc.subject	lanthanide complex
dc.subject	luminescent copolymer
dc.title	Cationic lanthanide luminescent copolymer: Design, synthesis and interaction with DNA
dc.type	Article

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Author Affiliations

The University of Hong Kong
City University of Hong Kong
Hubei University

Article: Cationic lanthanide luminescent copolymer: Design, synthesis and interaction with DNA

The HKU Scholars Hub has contact details for these author(s).