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Article: The primary somatosensory cortex largely contributes to the early part of the cortical response elicited by nociceptive stimuli

TitleThe primary somatosensory cortex largely contributes to the early part of the cortical response elicited by nociceptive stimuli
Authors
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2012, v. 59 n. 2, p. 1571-1581 How to Cite?
AbstractResearch on the cortical sources of nociceptive laser-evoked brain potentials (LEPs) began almost two decades ago (Tarkka and Treede, 1993). Whereas there is a large consensus on the sources of the late part of the LEP waveform (N2 and P2 waves), the relative contribution of the primary somatosensory cortex (S1) to the early part of the LEP waveform (N1 wave) is still debated. To address this issue we recorded LEPs elicited by the stimulation of four limbs in a large population (n=35). Early LEP generators were estimated both at single-subject and group level, using three different approaches: distributed source analysis, dipolar source modeling, and probabilistic independent component analysis (ICA). We show that the scalp distribution of the earliest LEP response to hand stimulation was maximal over the central-parietal electrodes contralateral to the stimulated side, while that of the earliest LEP response to foot stimulation was maximal over the central-parietal midline electrodes. Crucially, all three approaches indicated hand and foot S1 areas as generators of the earliest LEP response. Altogether, these findings indicate that the earliest part of the scalp response elicited by a selective nociceptive stimulus is largely explained by activity in the contralateral S1, with negligible contribution from the secondary somatosensory cortex (S2).
Persistent Identifierhttp://hdl.handle.net/10722/159743
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorValentini, Een_HK
dc.contributor.authorHu, Len_HK
dc.contributor.authorChakrabarti, Ben_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorAglioti, SMen_HK
dc.contributor.authorIannetti, GDen_HK
dc.date.accessioned2012-08-16T05:55:27Z-
dc.date.available2012-08-16T05:55:27Z-
dc.date.issued2012en_HK
dc.identifier.citationNeuroimage, 2012, v. 59 n. 2, p. 1571-1581en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159743-
dc.description.abstractResearch on the cortical sources of nociceptive laser-evoked brain potentials (LEPs) began almost two decades ago (Tarkka and Treede, 1993). Whereas there is a large consensus on the sources of the late part of the LEP waveform (N2 and P2 waves), the relative contribution of the primary somatosensory cortex (S1) to the early part of the LEP waveform (N1 wave) is still debated. To address this issue we recorded LEPs elicited by the stimulation of four limbs in a large population (n=35). Early LEP generators were estimated both at single-subject and group level, using three different approaches: distributed source analysis, dipolar source modeling, and probabilistic independent component analysis (ICA). We show that the scalp distribution of the earliest LEP response to hand stimulation was maximal over the central-parietal electrodes contralateral to the stimulated side, while that of the earliest LEP response to foot stimulation was maximal over the central-parietal midline electrodes. Crucially, all three approaches indicated hand and foot S1 areas as generators of the earliest LEP response. Altogether, these findings indicate that the earliest part of the scalp response elicited by a selective nociceptive stimulus is largely explained by activity in the contralateral S1, with negligible contribution from the secondary somatosensory cortex (S2).en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroimageen_HK
dc.subject.meshAdulten_HK
dc.subject.meshElectroencephalography - methodsen_HK
dc.subject.meshEvoked Potentials, Somatosensoryen_HK
dc.subject.meshNociceptive Pain - physiopathologyen_HK
dc.subject.meshSomatosensory Cortex - physiopathologyen_HK
dc.titleThe primary somatosensory cortex largely contributes to the early part of the cortical response elicited by nociceptive stimulien_HK
dc.typeArticleen_HK
dc.identifier.emailHu, L: hulitju@hku.hken_HK
dc.identifier.emailHu, Y: yhud@hku.hk-
dc.identifier.emailIannetti, GD: g.iannetti@ucl.ac.uk-
dc.identifier.authorityHu, Y=rp00432en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2011.08.069en_HK
dc.identifier.pmid21906686-
dc.identifier.scopuseid_2-s2.0-83055172768en_HK
dc.identifier.hkuros202317en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83055172768&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue2en_HK
dc.identifier.spage1571en_HK
dc.identifier.epage1581en_HK
dc.identifier.isiWOS:000298210600078-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIannetti, GD=7005461102en_HK
dc.identifier.scopusauthoridAglioti, SM=7007006465en_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK
dc.identifier.scopusauthoridChakrabarti, B=35253357900en_HK
dc.identifier.scopusauthoridHu, L=34770075600en_HK
dc.identifier.scopusauthoridValentini, E=22981981100en_HK

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