File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3

TitleSodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3
Authors
Issue Date2012
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes, 2012, v. 61 n. 4, p. 797-806 How to Cite?
AbstractFibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor. FGF21 expression was examined in serum and liver after injection of sodium butyrate into dietary obese C57BL/6J mice. The role of FGF21 was determined using antibody neutralization or knockout mice. FGF21 transcription was investigated in liver and HepG2 hepatocytes. Trichostatin A (TSA) was used in the control as an HDAC inhibitor. Butyrate was compared with bezafibrate and fenofibrate in the induction of FGF21 expression. Butyrate induced FGF21 in the serum, enhanced fatty acid oxidation in mice, and stimulated ketone body production in liver. The butyrate activity was significantly reduced by the FGF21 antibody or gene knockout. Butyrate induced FGF21 gene expression in liver and hepatocytes by inhibiting HDAC3, which suppresses peroxisome proliferator-activated receptor-alpha function. Butyrate enhanced bezafibrate activity in the induction of FGF21. TSA exhibited a similar set of activities to butyrate. FGF21 mediates the butyrate activity to increase fatty acid use and ketogenesis. Butyrate induces FGF21 transcription by inhibition of HDAC3.
Persistent Identifierhttp://hdl.handle.net/10722/159705
ISSN
2015 Impact Factor: 8.784
2015 SCImago Journal Rankings: 5.185
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorGao, Zen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorYe, Xen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorYe, Jen_US
dc.contributor.authorJia, Wen_US
dc.date.accessioned2012-08-16T05:54:12Z-
dc.date.available2012-08-16T05:54:12Z-
dc.date.issued2012en_US
dc.identifier.citationDiabetes, 2012, v. 61 n. 4, p. 797-806en_US
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://hdl.handle.net/10722/159705-
dc.description.abstractFibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor. FGF21 expression was examined in serum and liver after injection of sodium butyrate into dietary obese C57BL/6J mice. The role of FGF21 was determined using antibody neutralization or knockout mice. FGF21 transcription was investigated in liver and HepG2 hepatocytes. Trichostatin A (TSA) was used in the control as an HDAC inhibitor. Butyrate was compared with bezafibrate and fenofibrate in the induction of FGF21 expression. Butyrate induced FGF21 in the serum, enhanced fatty acid oxidation in mice, and stimulated ketone body production in liver. The butyrate activity was significantly reduced by the FGF21 antibody or gene knockout. Butyrate induced FGF21 gene expression in liver and hepatocytes by inhibiting HDAC3, which suppresses peroxisome proliferator-activated receptor-alpha function. Butyrate enhanced bezafibrate activity in the induction of FGF21. TSA exhibited a similar set of activities to butyrate. FGF21 mediates the butyrate activity to increase fatty acid use and ketogenesis. Butyrate induces FGF21 transcription by inhibition of HDAC3.-
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/-
dc.relation.ispartofDiabetesen_US
dc.subject.meshBezafibrate - pharmacology-
dc.subject.meshButyrates - pharmacology-
dc.subject.meshFibroblast Growth Factors - genetics - metabolism-
dc.subject.meshGene Expression Regulation - drug effects - physiology-
dc.subject.meshHistone Deacetylases - metabolism-
dc.titleSodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3en_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1939-327X (Electronic)0012-1797 (Linkin&volume=61&issue=4&spage=797&epage=806&date=2012&atitle=Sodium+butyrate+stimulates+expression+of+fibroblast+growth+factor+21+in+liver+by+inhibition+of+histone+deacetylase+3en_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailYe, J: yej@pbrc.edu-
dc.identifier.emailJia, W: wpjia@sjtu.edu.cn-
dc.identifier.authorityXu, A=rp00485en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2337/db11-0846-
dc.identifier.pmid22338096-
dc.identifier.pmcidPMC3314370-
dc.identifier.scopuseid_2-s2.0-84859529243-
dc.identifier.hkuros205683en_US
dc.identifier.volume61en_US
dc.identifier.issue4en_US
dc.identifier.spage797en_US
dc.identifier.epage806en_US
dc.identifier.isiWOS:000301959800008-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats