Article: The role of circulating serotonin in the development of chronic obstructive pulmonary disease

File Download

content.pdf

Links for fulltext
(May Require Subscription)

Publisher Website: 10.1371/journal.pone.0031617
Scopus: eid_2-s2.0-84856512594
PMID: 22319639

Supplementary

Citations:
- Scopus:
- Web of Science:
- PubMed Central:
Item Statistics (The Hub)
Appears in Collections:
- Medicine: Journal/Magazine Articles

Title	The role of circulating serotonin in the development of chronic obstructive pulmonary disease
Authors	Lau, WKW Chan, MMW Yip, BHK Cheung, AHK Ip, MSM Mak, JCW The COPD Study Group of the Hong Kong Thoracic Society
Keywords	Age Chronic obstructive lung disease Cigarette smoking Disease association Enzyme linked immunosorbent assay
Issue Date	2012
Publisher	Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation	PLoS One, 2012, v. 7 n. 2, article no. e31617 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0031617
Abstract	BACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.
ISSN	1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519
DOI	http://dx.doi.org/10.1371/journal.pone.0031617
PubMed Central ID	PMC3272036

DC Field	Value
dc.contributor.author	Lau, WKW
dc.contributor.author	Chan, MMW
dc.contributor.author	Yip, BHK
dc.contributor.author	Cheung, AHK
dc.contributor.author	Ip, MSM
dc.contributor.author	Mak, JCW
dc.contributor.author	The COPD Study Group of the Hong Kong Thoracic Society
dc.date.accessioned	2012-08-16T05:53:51Z
dc.date.available	2012-08-16T05:53:51Z
dc.date.issued	2012
dc.description.abstract	BACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.
dc.description.nature	published_or_final_version
dc.identifier.citation	PLoS One, 2012, v. 7 n. 2, article no. e31617 [How to Cite?] DOI: http://dx.doi.org/10.1371/journal.pone.0031617
dc.identifier.doi	http://dx.doi.org/10.1371/journal.pone.0031617
dc.identifier.hkuros	204345
dc.identifier.issn	1932-6203 2011 Impact Factor: 4.092 2011 SCImago Journal Rankings: 0.519
dc.identifier.issue	2, article no. e31617
dc.identifier.pmcid	PMC3272036
dc.identifier.pmid	22319639
dc.identifier.scopus	eid_2-s2.0-84856512594
dc.identifier.uri	http://hdl.handle.net/10722/159666
dc.identifier.volume	7
dc.language	eng
dc.publisher	Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
dc.publisher.place	United States
dc.relation.ispartof	PLoS One
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.subject	Age
dc.subject	Chronic obstructive lung disease
dc.subject	Cigarette smoking
dc.subject	Disease association
dc.subject	Enzyme linked immunosorbent assay
dc.title	The role of circulating serotonin in the development of chronic obstructive pulmonary disease
dc.type	Article

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Lau, WKW</contributor.author><contributor.author>Chan, MMW</contributor.author><contributor.author>Yip, BHK</contributor.author><contributor.author>Cheung, AHK</contributor.author><contributor.author>Ip, MSM</contributor.author><contributor.author>Mak, JCW</contributor.author><contributor.author>The COPD Study Group of the Hong Kong Thoracic Society</contributor.author><date.accessioned>2012-08-16T05:53:51Z</date.accessioned><date.available>2012-08-16T05:53:51Z</date.available><date.issued>2012</date.issued><identifier.citation>PLoS One, 2012, v. 7 n. 2, article no. e31617</identifier.citation><identifier.issn>1932-6203</identifier.issn><identifier.uri>http://hdl.handle.net/10722/159666</identifier.uri><description.abstract>BACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p&lt;0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.</description.abstract><language>eng</language><publisher>Public Library of Science. The Journal&apos;s web site is located at http://www.plosone.org/home.action</publisher><relation.ispartof>PLoS One</relation.ispartof><rights>Creative Commons: Attribution 3.0 Hong Kong License</rights><subject>Age</subject><subject>Chronic obstructive lung disease</subject><subject>Cigarette smoking</subject><subject>Disease association</subject><subject>Enzyme linked immunosorbent assay</subject><title>The role of circulating serotonin in the development of chronic obstructive pulmonary disease</title><type>Article</type><description.nature>published_or_final_version</description.nature><identifier.doi>10.1371/journal.pone.0031617</identifier.doi><identifier.pmid>22319639</identifier.pmid><identifier.pmcid>PMC3272036</identifier.pmcid><identifier.scopus>eid_2-s2.0-84856512594</identifier.scopus><identifier.hkuros>204345</identifier.hkuros><identifier.volume>7</identifier.volume><identifier.issue>2, article no. e31617</identifier.issue><publisher.place>United States</publisher.place><bitstream.url>http://hub.hku.hk/bitstream/10722/159666/1/content.pdf</bitstream.url></item>

Author Affiliations

The University of Hong Kong