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Article: The role of circulating serotonin in the development of chronic obstructive pulmonary disease

TitleThe role of circulating serotonin in the development of chronic obstructive pulmonary disease
Authors
KeywordsAge
Chronic obstructive lung disease
Cigarette smoking
Disease association
Enzyme linked immunosorbent assay
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 2, article no. e31617 How to Cite?
Abstract
BACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.
Persistent Identifierhttp://hdl.handle.net/10722/159666
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLau, WKWen_US
dc.contributor.authorChan, MMWen_US
dc.contributor.authorYip, BHKen_US
dc.contributor.authorCheung, AHKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorThe COPD Study Group of the Hong Kong Thoracic Society-
dc.date.accessioned2012-08-16T05:53:51Z-
dc.date.available2012-08-16T05:53:51Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 2, article no. e31617en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/159666-
dc.description.abstractBACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAge-
dc.subjectChronic obstructive lung disease-
dc.subjectCigarette smoking-
dc.subjectDisease association-
dc.subjectEnzyme linked immunosorbent assay-
dc.titleThe role of circulating serotonin in the development of chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US
dc.identifier.emailChan, MMW: mmwchan@hku.hken_US
dc.identifier.emailYip, BHK: yipben@hkucc.hku.hken_US
dc.identifier.emailCheung, AHK: ahkcheun@hkucc.hku.hken_US
dc.identifier.emailIp, MSM: msmip@hku.hken_US
dc.identifier.emailMak, JCW: judymak@hku.hk-
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0031617-
dc.identifier.pmid22319639-
dc.identifier.pmcidPMC3272036-
dc.identifier.scopuseid_2-s2.0-84856512594-
dc.identifier.hkuros204345en_US
dc.identifier.volume7en_US
dc.identifier.issue2, article no. e31617en_US
dc.identifier.eissn1932-6203-
dc.identifier.isiWOS:000302178400047-
dc.publisher.placeUnited States-

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