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Article: The role of circulating serotonin in the development of chronic obstructive pulmonary disease
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TitleThe role of circulating serotonin in the development of chronic obstructive pulmonary disease
 
AuthorsLau, WKW
Chan, MMW
Yip, BHK
Cheung, AHK
Ip, MSM
Mak, JCW
The COPD Study Group of the Hong Kong Thoracic Society
 
KeywordsAge
Chronic obstructive lung disease
Cigarette smoking
Disease association
Enzyme linked immunosorbent assay
 
Issue Date2012
 
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
CitationPLoS One, 2012, v. 7 n. 2, article no. e31617 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0031617
 
AbstractBACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.
 
ISSN1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
DOIhttp://dx.doi.org/10.1371/journal.pone.0031617
 
PubMed Central IDPMC3272036
 
ISI Accession Number IDWOS:000302178400047
 
DC FieldValue
dc.contributor.authorLau, WKW
 
dc.contributor.authorChan, MMW
 
dc.contributor.authorYip, BHK
 
dc.contributor.authorCheung, AHK
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorMak, JCW
 
dc.contributor.authorThe COPD Study Group of the Hong Kong Thoracic Society
 
dc.date.accessioned2012-08-16T05:53:51Z
 
dc.date.available2012-08-16T05:53:51Z
 
dc.date.issued2012
 
dc.description.abstractBACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p<0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPLoS One, 2012, v. 7 n. 2, article no. e31617 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0031617
 
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0031617
 
dc.identifier.eissn1932-6203
 
dc.identifier.hkuros204345
 
dc.identifier.isiWOS:000302178400047
 
dc.identifier.issn1932-6203
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
 
dc.identifier.issue2, article no. e31617
 
dc.identifier.pmcidPMC3272036
 
dc.identifier.pmid22319639
 
dc.identifier.scopuseid_2-s2.0-84856512594
 
dc.identifier.urihttp://hdl.handle.net/10722/159666
 
dc.identifier.volume7
 
dc.languageeng
 
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPLoS One
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectAge
 
dc.subjectChronic obstructive lung disease
 
dc.subjectCigarette smoking
 
dc.subjectDisease association
 
dc.subjectEnzyme linked immunosorbent assay
 
dc.titleThe role of circulating serotonin in the development of chronic obstructive pulmonary disease
 
dc.typeArticle
 
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<contributor.author>Chan, MMW</contributor.author>
<contributor.author>Yip, BHK</contributor.author>
<contributor.author>Cheung, AHK</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<contributor.author>Mak, JCW</contributor.author>
<contributor.author>The COPD Study Group of the Hong Kong Thoracic Society</contributor.author>
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<description.abstract>BACKGROUND: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. METHODS: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). RESULTS: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p&lt;0.0001). The effect remained significant after being adjusted for age and pack-years smoked (OR = 1.271, 95% CI = 1.134 to 1.408, p = 0.0003). Furthermore, plasma 5-HT was found to mediate the relation between pack-years smoked and COPD. A positive correlation (r = 0.303, p = 0.017) was found between plasma 5-HT levels and age in COPD, but not in the control subjects (r = -0.149, p = 0.108). CONCLUSION: Our results suggest that cigarette smoke-induced COPD is partially mediated by the plasma levels of 5-HT, and that these become elevated with increased age in COPD. The elevated plasma 5-HT levels in COPD might contribute to the pathogenesis of this disease.</description.abstract>
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<subject>Age</subject>
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Author Affiliations
  1. The University of Hong Kong