Article: Is human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002

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TitleIs human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002
AuthorsLi, C1
Samaranayake, N
Ong, KL2
Wong, HK1
Cheung, BMY1
KeywordsBody mass
Cytomegalovirus infection
Diabetes mellitus
Disease association
Ethnic difference
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
CitationPLoS One, 2012, v. 7 n. 7, article no. e39760 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0039760
AbstractPURPOSE: Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension. We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES). METHODS: We analyzed data on 2979 men and 3324 women in the NHANES 1999-2002. We included participants aged 16-49 years who had valid data on HCMV infection and hypertension. RESULTS: Of the participants, 54.7% had serologic evidence of HCMV infection and 17.5% had hypertension. There were ethnic differences in the prevalence of HCMV infection (P<0.001) and hypertension (P<0.001). The prevalence of both increased with age (P<0.001). Before adjustment, HCMV seropositivity was significantly associated with hypertension in women (OR = 1.63, 95% CI = 1.25-2.13, P = 0.001) but not in men. After adjustment for race/ethnicity, the association between HCMV seropositivity and hypertension in women remained significant (OR = 1.55, 95% CI = 1.20-2.02, P = 0.002). Further adjustment for body mass index, diabetes status and hypercholesterolemia attenuated the association (OR = 1.44, 95% CI = 1.10-1.90, P = 0.010). However, after adjusting for age, the association was no longer significant (OR = 1.24, 95% CI = 0.91-1.67, P = 0.162). CONCLUSIONS: In this nationally representative population-based survey, HCMV seropositivity is associated with hypertension in women in the NHANES population. This association is largely explained by the association of hypertension with age and the increase in past exposure to HCMV with age.
ISSN1932-6203
2011 Impact Factor: 4.092
2011 SCImago Journal Rankings: 0.519
DOIhttp://dx.doi.org/10.1371/journal.pone.0039760
PubMed Central IDPMC3388091
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, C
dc.contributor.authorSamaranayake, N
dc.contributor.authorOng, KL
dc.contributor.authorWong, HK
dc.contributor.authorCheung, BMY
dc.date.accessioned2012-08-16T05:53:50Z
dc.date.available2012-08-16T05:53:50Z
dc.date.issued2012
dc.description.abstractPURPOSE: Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension. We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES). METHODS: We analyzed data on 2979 men and 3324 women in the NHANES 1999-2002. We included participants aged 16-49 years who had valid data on HCMV infection and hypertension. RESULTS: Of the participants, 54.7% had serologic evidence of HCMV infection and 17.5% had hypertension. There were ethnic differences in the prevalence of HCMV infection (P<0.001) and hypertension (P<0.001). The prevalence of both increased with age (P<0.001). Before adjustment, HCMV seropositivity was significantly associated with hypertension in women (OR = 1.63, 95% CI = 1.25-2.13, P = 0.001) but not in men. After adjustment for race/ethnicity, the association between HCMV seropositivity and hypertension in women remained significant (OR = 1.55, 95% CI = 1.20-2.02, P = 0.002). Further adjustment for body mass index, diabetes status and hypercholesterolemia attenuated the association (OR = 1.44, 95% CI = 1.10-1.90, P = 0.010). However, after adjusting for age, the association was no longer significant (OR = 1.24, 95% CI = 0.91-1.67, P = 0.162). CONCLUSIONS: In this nationally representative population-based survey, HCMV seropositivity is associated with hypertension in women in the NHANES population. This association is largely explained by the association of hypertension with age and the increase in past exposure to HCMV with age.
dc.description.naturepublished_or_final_version
dc.identifier.citationPLoS One, 2012, v. 7 n. 7, article no. e39760 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0039760
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0039760
dc.identifier.hkuros204106
dc.identifier.issn1932-6203
2011 Impact Factor: 4.092
2011 SCImago Journal Rankings: 0.519
dc.identifier.issue7, article no. e39760
dc.identifier.pmcidPMC3388091
dc.identifier.pmid22768311
dc.identifier.scopuseid_2-s2.0-84863621393
dc.identifier.urihttp://hdl.handle.net/10722/159662
dc.identifier.volume7
dc.languageeng
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
dc.publisher.placeUnited States
dc.relation.ispartofPLoS One
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectBody mass
dc.subjectCytomegalovirus infection
dc.subjectDiabetes mellitus
dc.subjectDisease association
dc.subjectEthnic difference
dc.titleIs human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Heart Research Institute Australia