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Article: Is human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002

TitleIs human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002
Authors
KeywordsBody mass
Cytomegalovirus infection
Diabetes mellitus
Disease association
Ethnic difference
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 7, article no. e39760 How to Cite?
Abstract
PURPOSE: Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension. We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES). METHODS: We analyzed data on 2979 men and 3324 women in the NHANES 1999-2002. We included participants aged 16-49 years who had valid data on HCMV infection and hypertension. RESULTS: Of the participants, 54.7% had serologic evidence of HCMV infection and 17.5% had hypertension. There were ethnic differences in the prevalence of HCMV infection (P<0.001) and hypertension (P<0.001). The prevalence of both increased with age (P<0.001). Before adjustment, HCMV seropositivity was significantly associated with hypertension in women (OR = 1.63, 95% CI = 1.25-2.13, P = 0.001) but not in men. After adjustment for race/ethnicity, the association between HCMV seropositivity and hypertension in women remained significant (OR = 1.55, 95% CI = 1.20-2.02, P = 0.002). Further adjustment for body mass index, diabetes status and hypercholesterolemia attenuated the association (OR = 1.44, 95% CI = 1.10-1.90, P = 0.010). However, after adjusting for age, the association was no longer significant (OR = 1.24, 95% CI = 0.91-1.67, P = 0.162). CONCLUSIONS: In this nationally representative population-based survey, HCMV seropositivity is associated with hypertension in women in the NHANES population. This association is largely explained by the association of hypertension with age and the increase in past exposure to HCMV with age.
Persistent Identifierhttp://hdl.handle.net/10722/159662
ISSN
2013 Impact Factor: 3.534
2013 SCImago Journal Rankings: 1.724
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Heart Research Institute Australia
DC FieldValueLanguage
dc.contributor.authorLi, Cen_US
dc.contributor.authorSamaranayake, Nen_US
dc.contributor.authorOng, KLen_US
dc.contributor.authorWong, HKen_US
dc.contributor.authorCheung, BMYen_US
dc.date.accessioned2012-08-16T05:53:50Z-
dc.date.available2012-08-16T05:53:50Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 7, article no. e39760en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/159662-
dc.description.abstractPURPOSE: Recent studies have implicated the human cytomegalovirus (HCMV) as a possible pathogen for causing hypertension. We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES). METHODS: We analyzed data on 2979 men and 3324 women in the NHANES 1999-2002. We included participants aged 16-49 years who had valid data on HCMV infection and hypertension. RESULTS: Of the participants, 54.7% had serologic evidence of HCMV infection and 17.5% had hypertension. There were ethnic differences in the prevalence of HCMV infection (P<0.001) and hypertension (P<0.001). The prevalence of both increased with age (P<0.001). Before adjustment, HCMV seropositivity was significantly associated with hypertension in women (OR = 1.63, 95% CI = 1.25-2.13, P = 0.001) but not in men. After adjustment for race/ethnicity, the association between HCMV seropositivity and hypertension in women remained significant (OR = 1.55, 95% CI = 1.20-2.02, P = 0.002). Further adjustment for body mass index, diabetes status and hypercholesterolemia attenuated the association (OR = 1.44, 95% CI = 1.10-1.90, P = 0.010). However, after adjusting for age, the association was no longer significant (OR = 1.24, 95% CI = 0.91-1.67, P = 0.162). CONCLUSIONS: In this nationally representative population-based survey, HCMV seropositivity is associated with hypertension in women in the NHANES population. This association is largely explained by the association of hypertension with age and the increase in past exposure to HCMV with age.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBody mass-
dc.subjectCytomegalovirus infection-
dc.subjectDiabetes mellitus-
dc.subjectDisease association-
dc.subjectEthnic difference-
dc.titleIs human cytomegalovirus infection associated with hypertension? the United States National Health and Nutrition Examination Survey 1999-2002en_US
dc.typeArticleen_US
dc.identifier.emailCheung, BMY: mycheung@hku.hken_US
dc.identifier.authorityCheung, BMY=rp01321en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0039760-
dc.identifier.pmid22768311-
dc.identifier.pmcidPMC3388091-
dc.identifier.scopuseid_2-s2.0-84863621393-
dc.identifier.hkuros204106en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863621393&selection=ref&src=s&origin=recordpage-
dc.identifier.volume7en_US
dc.identifier.issue7, article no. e39760en_US
dc.identifier.isiWOS:000305966500024-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridLi, C=55235396800-
dc.identifier.scopusauthoridSamaranayake, NR=37081701500-
dc.identifier.scopusauthoridOng, KL=55277638900-
dc.identifier.scopusauthoridWong, HK=55305600000-
dc.identifier.scopusauthoridCheung, BMY=7103294806-

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