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Article: Dense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled study

TitleDense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled study
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2012, v. 7 n. 1 How to Cite?
AbstractBackground: Previous studies suggest that electroacupuncture possesses therapeutic benefits for depressive disorders. The purpose of this study was to determine whether dense cranial electroacupuncture stimulation (DCEAS) could enhance the antidepressant efficacy in the early phase of selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder (MDD). Methods: In this single-blind, randomized, controlled study, patients with MDD were randomly assigned to 9-session DCEAS or noninvasive electroacupuncture (n-EA) control procedure in combination with fluoxetine (FLX) for 3 weeks. Clinical outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression-severity (CGI-S), and Self-rating Depression Scale (SDS) as well as the response and remission rates. Results: Seventy-three patients were randomly assigned to n-EA (n = 35) and DCEAS (n = 38), of whom 34 in n-EA and 36 in DCEAS group were analyzed. DCEAS-treated patients displayed a significantly greater reduction from baseline in HAMD-17 scores at Day 3 through Day 21 and in SDS scores at Day 3 and Day 21 compared to patients receiving n-EA. DCEAS intervention also produced a higher rate of clinically significant response compared to n-EA procedure (19.4% (7/36) vs. 8.8% (3/34)). The incidence of adverse events was similar in the two groups. Conclusions: DCEAS is a safe and effective intervention that augments the antidepressant efficacy. It can be considered as an additional therapy in the early phase of SSRI treatment of depressed patients. © 2012 Zhang et al.
Persistent Identifierhttp://hdl.handle.net/10722/159605
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorNg, Ren_HK
dc.contributor.authorMan, SCen_HK
dc.contributor.authorLi, TYJen_HK
dc.contributor.authorWong, Wen_HK
dc.contributor.authorTan, QRen_HK
dc.contributor.authorWong, HKen_HK
dc.contributor.authorChung, KFen_HK
dc.contributor.authorWong, MTen_HK
dc.contributor.authorTsang, WKAen_HK
dc.contributor.authorYip, Kcen_HK
dc.contributor.authorZiea, Een_HK
dc.contributor.authorWong, VTen_HK
dc.date.accessioned2012-08-16T05:53:08Z-
dc.date.available2012-08-16T05:53:08Z-
dc.date.issued2012en_HK
dc.identifier.citationPlos One, 2012, v. 7 n. 1en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159605-
dc.description.abstractBackground: Previous studies suggest that electroacupuncture possesses therapeutic benefits for depressive disorders. The purpose of this study was to determine whether dense cranial electroacupuncture stimulation (DCEAS) could enhance the antidepressant efficacy in the early phase of selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder (MDD). Methods: In this single-blind, randomized, controlled study, patients with MDD were randomly assigned to 9-session DCEAS or noninvasive electroacupuncture (n-EA) control procedure in combination with fluoxetine (FLX) for 3 weeks. Clinical outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression-severity (CGI-S), and Self-rating Depression Scale (SDS) as well as the response and remission rates. Results: Seventy-three patients were randomly assigned to n-EA (n = 35) and DCEAS (n = 38), of whom 34 in n-EA and 36 in DCEAS group were analyzed. DCEAS-treated patients displayed a significantly greater reduction from baseline in HAMD-17 scores at Day 3 through Day 21 and in SDS scores at Day 3 and Day 21 compared to patients receiving n-EA. DCEAS intervention also produced a higher rate of clinically significant response compared to n-EA procedure (19.4% (7/36) vs. 8.8% (3/34)). The incidence of adverse events was similar in the two groups. Conclusions: DCEAS is a safe and effective intervention that augments the antidepressant efficacy. It can be considered as an additional therapy in the early phase of SSRI treatment of depressed patients. © 2012 Zhang et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntidepressive Agents, Second-Generation - administration and dosage-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshDepressive Disorder, Major - therapy-
dc.subject.meshElectroacupuncture - methods-
dc.subject.meshElectroconvulsive Therapy - methods-
dc.titleDense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled studyen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0029651en_HK
dc.identifier.pmid22238631-
dc.identifier.pmcidPMC3253099-
dc.identifier.scopuseid_2-s2.0-84855456776en_HK
dc.identifier.hkuros205006en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855456776&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue1en_HK
dc.identifier.eissn1932-6203-
dc.identifier.isiWOS:000301188800023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridNg, R=7102153803en_HK
dc.identifier.scopusauthoridMan, SC=54884459700en_HK
dc.identifier.scopusauthoridLi, TYJ=54884443500en_HK
dc.identifier.scopusauthoridWong, W=54884457500en_HK
dc.identifier.scopusauthoridTan, QR=7102120177en_HK
dc.identifier.scopusauthoridWong, HK=36920239700en_HK
dc.identifier.scopusauthoridChung, KF=38561123100en_HK
dc.identifier.scopusauthoridWong, MT=54884686300en_HK
dc.identifier.scopusauthoridTsang, WKA=54884725100en_HK
dc.identifier.scopusauthoridYip, Kc=28168097100en_HK
dc.identifier.scopusauthoridZiea, E=6507982323en_HK
dc.identifier.scopusauthoridWong, VT=16176799600en_HK

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