Article: Dense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled study

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TitleDense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled study
AuthorsZhang, ZJ2
Ng, R2
Man, SC2
Li, TYJ2
Wong, W2
Tan, QR3
Wong, HK2
Chung, KF2
Wong, MT4
Tsang, WKA4
Yip, Kc4
Ziea, E1
Wong, VT1
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
CitationPlos One, 2012, v. 7 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0029651
AbstractBackground: Previous studies suggest that electroacupuncture possesses therapeutic benefits for depressive disorders. The purpose of this study was to determine whether dense cranial electroacupuncture stimulation (DCEAS) could enhance the antidepressant efficacy in the early phase of selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder (MDD). Methods: In this single-blind, randomized, controlled study, patients with MDD were randomly assigned to 9-session DCEAS or noninvasive electroacupuncture (n-EA) control procedure in combination with fluoxetine (FLX) for 3 weeks. Clinical outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression-severity (CGI-S), and Self-rating Depression Scale (SDS) as well as the response and remission rates. Results: Seventy-three patients were randomly assigned to n-EA (n = 35) and DCEAS (n = 38), of whom 34 in n-EA and 36 in DCEAS group were analyzed. DCEAS-treated patients displayed a significantly greater reduction from baseline in HAMD-17 scores at Day 3 through Day 21 and in SDS scores at Day 3 and Day 21 compared to patients receiving n-EA. DCEAS intervention also produced a higher rate of clinically significant response compared to n-EA procedure (19.4% (7/36) vs. 8.8% (3/34)). The incidence of adverse events was similar in the two groups. Conclusions: DCEAS is a safe and effective intervention that augments the antidepressant efficacy. It can be considered as an additional therapy in the early phase of SSRI treatment of depressed patients. © 2012 Zhang et al.
ISSN1932-6203
2011 Impact Factor: 4.092
2011 SCImago Journal Rankings: 0.519
DOIhttp://dx.doi.org/10.1371/journal.pone.0029651
PubMed Central IDPMC3253099
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhang, ZJ
dc.contributor.authorNg, R
dc.contributor.authorMan, SC
dc.contributor.authorLi, TYJ
dc.contributor.authorWong, W
dc.contributor.authorTan, QR
dc.contributor.authorWong, HK
dc.contributor.authorChung, KF
dc.contributor.authorWong, MT
dc.contributor.authorTsang, WKA
dc.contributor.authorYip, Kc
dc.contributor.authorZiea, E
dc.contributor.authorWong, VT
dc.date.accessioned2012-08-16T05:53:08Z
dc.date.available2012-08-16T05:53:08Z
dc.date.issued2012
dc.description.abstractBackground: Previous studies suggest that electroacupuncture possesses therapeutic benefits for depressive disorders. The purpose of this study was to determine whether dense cranial electroacupuncture stimulation (DCEAS) could enhance the antidepressant efficacy in the early phase of selective serotonin reuptake inhibitor (SSRI) treatment of major depressive disorder (MDD). Methods: In this single-blind, randomized, controlled study, patients with MDD were randomly assigned to 9-session DCEAS or noninvasive electroacupuncture (n-EA) control procedure in combination with fluoxetine (FLX) for 3 weeks. Clinical outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), Clinical Global Impression-severity (CGI-S), and Self-rating Depression Scale (SDS) as well as the response and remission rates. Results: Seventy-three patients were randomly assigned to n-EA (n = 35) and DCEAS (n = 38), of whom 34 in n-EA and 36 in DCEAS group were analyzed. DCEAS-treated patients displayed a significantly greater reduction from baseline in HAMD-17 scores at Day 3 through Day 21 and in SDS scores at Day 3 and Day 21 compared to patients receiving n-EA. DCEAS intervention also produced a higher rate of clinically significant response compared to n-EA procedure (19.4% (7/36) vs. 8.8% (3/34)). The incidence of adverse events was similar in the two groups. Conclusions: DCEAS is a safe and effective intervention that augments the antidepressant efficacy. It can be considered as an additional therapy in the early phase of SSRI treatment of depressed patients. © 2012 Zhang et al.
dc.description.naturepublished_or_final_version
dc.identifier.citationPlos One, 2012, v. 7 n. 1 [How to Cite?]
DOI: http://dx.doi.org/10.1371/journal.pone.0029651
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0029651
dc.identifier.hkuros205006
dc.identifier.issn1932-6203
2011 Impact Factor: 4.092
2011 SCImago Journal Rankings: 0.519
dc.identifier.issue1
dc.identifier.pmcidPMC3253099
dc.identifier.pmid22238631
dc.identifier.scopuseid_2-s2.0-84855456776
dc.identifier.urihttp://hdl.handle.net/10722/159605
dc.identifier.volume7
dc.languageeng
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
dc.publisher.placeUnited States
dc.relation.ispartofPLoS ONE
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAntidepressive Agents, Second-Generation - administration and dosage
dc.subject.meshCombined Modality Therapy
dc.subject.meshDepressive Disorder, Major - therapy
dc.subject.meshElectroacupuncture - methods
dc.subject.meshElectroconvulsive Therapy - methods
dc.titleDense cranial electroacupuncture stimulation for major depressive disorder-A single-blind, randomized, controlled study
dc.typeArticle
Author Affiliations
  1. Hong Kong Hospital Authority
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. The Fourth Military Medical University
  4. Kowloon Hospital