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Article: Negative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffolds
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TitleNegative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffolds
 
AuthorsTong, HW
Wang, M
 
KeywordsElectrospinning
Nanofibers
Negative voltage
Charge retention
Tissue engineering
 
Issue Date2012
 
PublisherWorld Scientific Publishing Co. Pte. Ltd. The Journal's web site is located at http://www.worldscinet.com/nl/nl.shtml
 
CitationNano LIFE, 2012, v. 2 n. 1, article no. 1250004, p. 1250004-1-1250004-16 [How to Cite?]
DOI: http://dx.doi.org/10.1142/S1793984411000384
 
AbstractPositive voltage electrospinning (PVES) has been mainly used for forming fibrous polymer scaffolds for different applications including tissue engineering. There is virtually no report on negative voltage electrospinning (NVES) of tissue engineering scaffolds. In this study, NVES of four biopolymers, namely, gelatin, chitosan, poly(lactic-co-glycolic acid) (PLGA), and polybutylene terephthalate (PBT), to form nanofibrous membranes was systematically investigated. For comparisons, PVES of these polymers was also conducted. It was found that chitosan fibers could not be produced using NVES. Under NVES or PVES, the fiber diameter of electrospun scaffolds generally increased with increasing needle inner diameter and polymer solution concentration but decreased with increasing working distance for all four polymers. Neither NVES nor PVES altered the chemical structure of gelatin, PLGA, and PBT. PVES and NVES resulted in fibrous membranes bearing positive charges and negative charges, respectively. PLGA and PBT fibrous membranes retained around 30% and 50%, respectively, of the initial charge one week after electrospinning. Charges on gelatin and chitosan fibrous membranes were almost completely dissipated within 60 min of electrospinning. For all four polymers, under either PVES or NVES, the retained charges on fibrous membranes increased with increasing applied electrospinning voltage. This study explored a new approach for forming fibrous scaffolds by using NVES and has opened a new area for developing negatively charged fibrous scaffolds for tissue engineering applications.
 
ISSN1793-9844
 
DOIhttp://dx.doi.org/10.1142/S1793984411000384
 
DC FieldValue
dc.contributor.authorTong, HW
 
dc.contributor.authorWang, M
 
dc.date.accessioned2012-08-16T05:52:40Z
 
dc.date.available2012-08-16T05:52:40Z
 
dc.date.issued2012
 
dc.description.abstractPositive voltage electrospinning (PVES) has been mainly used for forming fibrous polymer scaffolds for different applications including tissue engineering. There is virtually no report on negative voltage electrospinning (NVES) of tissue engineering scaffolds. In this study, NVES of four biopolymers, namely, gelatin, chitosan, poly(lactic-co-glycolic acid) (PLGA), and polybutylene terephthalate (PBT), to form nanofibrous membranes was systematically investigated. For comparisons, PVES of these polymers was also conducted. It was found that chitosan fibers could not be produced using NVES. Under NVES or PVES, the fiber diameter of electrospun scaffolds generally increased with increasing needle inner diameter and polymer solution concentration but decreased with increasing working distance for all four polymers. Neither NVES nor PVES altered the chemical structure of gelatin, PLGA, and PBT. PVES and NVES resulted in fibrous membranes bearing positive charges and negative charges, respectively. PLGA and PBT fibrous membranes retained around 30% and 50%, respectively, of the initial charge one week after electrospinning. Charges on gelatin and chitosan fibrous membranes were almost completely dissipated within 60 min of electrospinning. For all four polymers, under either PVES or NVES, the retained charges on fibrous membranes increased with increasing applied electrospinning voltage. This study explored a new approach for forming fibrous scaffolds by using NVES and has opened a new area for developing negatively charged fibrous scaffolds for tissue engineering applications.
 
dc.identifier.citationNano LIFE, 2012, v. 2 n. 1, article no. 1250004, p. 1250004-1-1250004-16 [How to Cite?]
DOI: http://dx.doi.org/10.1142/S1793984411000384
 
dc.identifier.doihttp://dx.doi.org/10.1142/S1793984411000384
 
dc.identifier.epage1250004-16
 
dc.identifier.hkuros204406
 
dc.identifier.issn1793-9844
 
dc.identifier.issue1
 
dc.identifier.spage1250004-1
 
dc.identifier.urihttp://hdl.handle.net/10722/159569
 
dc.identifier.volume2
 
dc.languageeng
 
dc.publisherWorld Scientific Publishing Co. Pte. Ltd. The Journal's web site is located at http://www.worldscinet.com/nl/nl.shtml
 
dc.publisher.placeSingapore
 
dc.relation.ispartofNano LIFE
 
dc.rightsNano LIFE. Copyright © World Scientific Publishing Co. Pte. Ltd.
 
dc.subjectElectrospinning
 
dc.subjectNanofibers
 
dc.subjectNegative voltage
 
dc.subjectCharge retention
 
dc.subjectTissue engineering
 
dc.titleNegative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffolds
 
dc.typeArticle
 
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<subject>Electrospinning</subject>
<subject>Nanofibers</subject>
<subject>Negative voltage</subject>
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