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Article: Negative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffolds

TitleNegative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffolds
Authors
KeywordsElectrospinning
Nanofibers
Negative voltage
Charge retention
Tissue engineering
Issue Date2012
PublisherWorld Scientific Publishing Co. Pte. Ltd. The Journal's web site is located at http://www.worldscinet.com/nl/nl.shtml
Citation
Nano LIFE, 2012, v. 2 n. 1, article no. 1250004, p. 1250004-1-1250004-16 How to Cite?
AbstractPositive voltage electrospinning (PVES) has been mainly used for forming fibrous polymer scaffolds for different applications including tissue engineering. There is virtually no report on negative voltage electrospinning (NVES) of tissue engineering scaffolds. In this study, NVES of four biopolymers, namely, gelatin, chitosan, poly(lactic-co-glycolic acid) (PLGA), and polybutylene terephthalate (PBT), to form nanofibrous membranes was systematically investigated. For comparisons, PVES of these polymers was also conducted. It was found that chitosan fibers could not be produced using NVES. Under NVES or PVES, the fiber diameter of electrospun scaffolds generally increased with increasing needle inner diameter and polymer solution concentration but decreased with increasing working distance for all four polymers. Neither NVES nor PVES altered the chemical structure of gelatin, PLGA, and PBT. PVES and NVES resulted in fibrous membranes bearing positive charges and negative charges, respectively. PLGA and PBT fibrous membranes retained around 30% and 50%, respectively, of the initial charge one week after electrospinning. Charges on gelatin and chitosan fibrous membranes were almost completely dissipated within 60 min of electrospinning. For all four polymers, under either PVES or NVES, the retained charges on fibrous membranes increased with increasing applied electrospinning voltage. This study explored a new approach for forming fibrous scaffolds by using NVES and has opened a new area for developing negatively charged fibrous scaffolds for tissue engineering applications.
Persistent Identifierhttp://hdl.handle.net/10722/159569
ISSN

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-08-16T05:52:40Z-
dc.date.available2012-08-16T05:52:40Z-
dc.date.issued2012en_US
dc.identifier.citationNano LIFE, 2012, v. 2 n. 1, article no. 1250004, p. 1250004-1-1250004-16en_US
dc.identifier.issn1793-9844-
dc.identifier.urihttp://hdl.handle.net/10722/159569-
dc.description.abstractPositive voltage electrospinning (PVES) has been mainly used for forming fibrous polymer scaffolds for different applications including tissue engineering. There is virtually no report on negative voltage electrospinning (NVES) of tissue engineering scaffolds. In this study, NVES of four biopolymers, namely, gelatin, chitosan, poly(lactic-co-glycolic acid) (PLGA), and polybutylene terephthalate (PBT), to form nanofibrous membranes was systematically investigated. For comparisons, PVES of these polymers was also conducted. It was found that chitosan fibers could not be produced using NVES. Under NVES or PVES, the fiber diameter of electrospun scaffolds generally increased with increasing needle inner diameter and polymer solution concentration but decreased with increasing working distance for all four polymers. Neither NVES nor PVES altered the chemical structure of gelatin, PLGA, and PBT. PVES and NVES resulted in fibrous membranes bearing positive charges and negative charges, respectively. PLGA and PBT fibrous membranes retained around 30% and 50%, respectively, of the initial charge one week after electrospinning. Charges on gelatin and chitosan fibrous membranes were almost completely dissipated within 60 min of electrospinning. For all four polymers, under either PVES or NVES, the retained charges on fibrous membranes increased with increasing applied electrospinning voltage. This study explored a new approach for forming fibrous scaffolds by using NVES and has opened a new area for developing negatively charged fibrous scaffolds for tissue engineering applications.-
dc.languageengen_US
dc.publisherWorld Scientific Publishing Co. Pte. Ltd. The Journal's web site is located at http://www.worldscinet.com/nl/nl.shtml-
dc.relation.ispartofNano LIFEen_US
dc.rightsNano LIFE. Copyright © World Scientific Publishing Co. Pte. Ltd.-
dc.subjectElectrospinning-
dc.subjectNanofibers-
dc.subjectNegative voltage-
dc.subjectCharge retention-
dc.subjectTissue engineering-
dc.titleNegative voltage electrospinning and positive voltage electrospinning of tissue engineering scaffolds: a comparative study and charge retention on scaffoldsen_US
dc.typeArticleen_US
dc.identifier.emailTong, HW: meboris@hku.hken_US
dc.identifier.emailWang, M: memwang@hku.hken_US
dc.identifier.authorityWang, M=rp00185en_US
dc.identifier.doi10.1142/S1793984411000384-
dc.identifier.hkuros204406en_US
dc.identifier.volume2en_US
dc.identifier.issue1-
dc.identifier.spage1250004-1en_US
dc.identifier.epage1250004-16en_US
dc.publisher.placeSingapore-

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