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Article: Osmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents
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TitleOsmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents
 
AuthorsNi, WX2
Man, WL2
Yiu, SM2
Ho, M2
Cheung, MTW2
Ko, CC2
Che, CM1
Lam, YW2
Lau, TC2
 
KeywordsAnti-tumor agents
Antiproliferative activities
Cellular uptake
Hela cell
Heterocycles
 
Issue Date2012
 
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
 
CitationChemical Science, 2012, v. 3 n. 5, p. 1582-1588 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2sc01031c
 
AbstractEight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.
 
ISSN2041-6520
2012 Impact Factor: 8.314
 
DOIhttp://dx.doi.org/10.1039/c2sc01031c
 
DC FieldValue
dc.contributor.authorNi, WX
 
dc.contributor.authorMan, WL
 
dc.contributor.authorYiu, SM
 
dc.contributor.authorHo, M
 
dc.contributor.authorCheung, MTW
 
dc.contributor.authorKo, CC
 
dc.contributor.authorChe, CM
 
dc.contributor.authorLam, YW
 
dc.contributor.authorLau, TC
 
dc.date.accessioned2012-08-16T05:49:07Z
 
dc.date.available2012-08-16T05:49:07Z
 
dc.date.issued2012
 
dc.description.abstractEight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.
 
dc.identifier.citationChemical Science, 2012, v. 3 n. 5, p. 1582-1588 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c2sc01031c
 
dc.identifier.doihttp://dx.doi.org/10.1039/c2sc01031c
 
dc.identifier.epage1588
 
dc.identifier.hkuros205355
 
dc.identifier.issn2041-6520
2012 Impact Factor: 8.314
 
dc.identifier.issue5
 
dc.identifier.scopuseid_2-s2.0-84859336852
 
dc.identifier.spage1582
 
dc.identifier.urihttp://hdl.handle.net/10722/159405
 
dc.identifier.volume3
 
dc.languageeng
 
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofChemical Science
 
dc.subjectAnti-tumor agents
 
dc.subjectAntiproliferative activities
 
dc.subjectCellular uptake
 
dc.subjectHela cell
 
dc.subjectHeterocycles
 
dc.titleOsmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents
 
dc.typeArticle
 
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<item><contributor.author>Ni, WX</contributor.author>
<contributor.author>Man, WL</contributor.author>
<contributor.author>Yiu, SM</contributor.author>
<contributor.author>Ho, M</contributor.author>
<contributor.author>Cheung, MTW</contributor.author>
<contributor.author>Ko, CC</contributor.author>
<contributor.author>Che, CM</contributor.author>
<contributor.author>Lam, YW</contributor.author>
<contributor.author>Lau, TC</contributor.author>
<date.accessioned>2012-08-16T05:49:07Z</date.accessioned>
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<description.abstract>Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. &#169; 2012 The Royal Society of Chemistry.</description.abstract>
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<subject>Anti-tumor agents</subject>
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Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  2. City University of Hong Kong