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Article: Osmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents

TitleOsmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agents
Authors
KeywordsAnti-tumor agents
Antiproliferative activities
Cellular uptake
Hela cell
Heterocycles
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2012, v. 3 n. 5, p. 1582-1588 How to Cite?
AbstractEight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/159405
ISSN
2014 Impact Factor: 9.211
2014 SCImago Journal Rankings: 4.455
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNi, WXen_US
dc.contributor.authorMan, WLen_US
dc.contributor.authorYiu, SMen_US
dc.contributor.authorHo, Men_US
dc.contributor.authorCheung, MTWen_US
dc.contributor.authorKo, CCen_US
dc.contributor.authorChe, CMen_US
dc.contributor.authorLam, YWen_US
dc.contributor.authorLau, TCen_US
dc.date.accessioned2012-08-16T05:49:07Z-
dc.date.available2012-08-16T05:49:07Z-
dc.date.issued2012en_US
dc.identifier.citationChemical Science, 2012, v. 3 n. 5, p. 1582-1588en_US
dc.identifier.issn2041-6520-
dc.identifier.urihttp://hdl.handle.net/10722/159405-
dc.description.abstractEight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA. © 2012 The Royal Society of Chemistry.-
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp-
dc.relation.ispartofChemical Scienceen_US
dc.subjectAnti-tumor agents-
dc.subjectAntiproliferative activities-
dc.subjectCellular uptake-
dc.subjectHela cell-
dc.subjectHeterocycles-
dc.titleOsmium(VI) nitrido complexes bearing azole heterocycles: a new class of antitumor agentsen_US
dc.typeArticleen_US
dc.identifier.emailChe, CM: cmche@hku.hken_US
dc.identifier.emailLam, YW: yunwlam@cityu.edu.hk-
dc.identifier.emailLau, TC: bhtclau@cityu.edu.hk-
dc.identifier.authorityChe, CM=rp00670en_US
dc.identifier.doi10.1039/c2sc01031c-
dc.identifier.scopuseid_2-s2.0-84859336852-
dc.identifier.hkuros205355en_US
dc.identifier.volume3en_US
dc.identifier.issue5-
dc.identifier.spage1582en_US
dc.identifier.epage1588en_US
dc.identifier.isiWOS:000302319000029-
dc.publisher.placeUnited Kingdom-

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