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Article: An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling
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TitleAn anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling
 
AuthorsLaiFung Chan, S1
WaiYin Sun, R1
Choi, MY1
Zeng, Y1
Shek, L1
SinYin Chui, S1
Che, CM1
 
KeywordsCancer cell lines
Catenin signaling
Complex 1
Dna binding
Dna micro-array
 
Issue Date2011
 
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
 
CitationChemical Science, 2011, v. 2 n. 9, p. 1788-1792 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c1sc00203a
 
AbstractA new trinuclear ruthenium complex [Ru III 3(TSA-H) 2(TSA) 4][NEt 4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H 2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses. © The Royal Society of Chemistry 2011.
 
ISSN2041-6520
2013 Impact Factor: 8.601
 
DOIhttp://dx.doi.org/10.1039/c1sc00203a
 
ISI Accession Number IDWOS:000293693700021
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLaiFung Chan, S
 
dc.contributor.authorWaiYin Sun, R
 
dc.contributor.authorChoi, MY
 
dc.contributor.authorZeng, Y
 
dc.contributor.authorShek, L
 
dc.contributor.authorSinYin Chui, S
 
dc.contributor.authorChe, CM
 
dc.date.accessioned2012-08-16T05:49:07Z
 
dc.date.available2012-08-16T05:49:07Z
 
dc.date.issued2011
 
dc.description.abstractA new trinuclear ruthenium complex [Ru III 3(TSA-H) 2(TSA) 4][NEt 4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H 2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses. © The Royal Society of Chemistry 2011.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationChemical Science, 2011, v. 2 n. 9, p. 1788-1792 [How to Cite?]
DOI: http://dx.doi.org/10.1039/c1sc00203a
 
dc.identifier.doihttp://dx.doi.org/10.1039/c1sc00203a
 
dc.identifier.epage1792
 
dc.identifier.hkuros205322
 
dc.identifier.isiWOS:000293693700021
 
dc.identifier.issn2041-6520
2013 Impact Factor: 8.601
 
dc.identifier.issue9
 
dc.identifier.scopuseid_2-s2.0-81355149545
 
dc.identifier.spage1788
 
dc.identifier.urihttp://hdl.handle.net/10722/159403
 
dc.identifier.volume2
 
dc.languageeng
 
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofChemical Science
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCancer cell lines
 
dc.subjectCatenin signaling
 
dc.subjectComplex 1
 
dc.subjectDna binding
 
dc.subjectDna micro-array
 
dc.titleAn anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling
 
dc.typeArticle
 
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<contributor.author>Shek, L</contributor.author>
<contributor.author>SinYin Chui, S</contributor.author>
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Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong