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Article: An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling

TitleAn anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling
Authors
KeywordsCancer cell lines
Catenin signaling
Complex 1
Dna binding
Dna micro-array
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2011, v. 2 n. 9, p. 1788-1792 How to Cite?
AbstractA new trinuclear ruthenium complex [Ru III 3(TSA-H) 2(TSA) 4][NEt 4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H 2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses. © The Royal Society of Chemistry 2011.
Persistent Identifierhttp://hdl.handle.net/10722/159403
ISSN
2015 Impact Factor: 9.144
2015 SCImago Journal Rankings: 4.974
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLaiFung Chan, Sen_HK
dc.contributor.authorWaiYin Sun, Ren_HK
dc.contributor.authorChoi, MYen_HK
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorShek, Len_HK
dc.contributor.authorSinYin Chui, Sen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2012-08-16T05:49:07Z-
dc.date.available2012-08-16T05:49:07Z-
dc.date.issued2011en_HK
dc.identifier.citationChemical Science, 2011, v. 2 n. 9, p. 1788-1792en_HK
dc.identifier.issn2041-6520en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159403-
dc.description.abstractA new trinuclear ruthenium complex [Ru III 3(TSA-H) 2(TSA) 4][NEt 4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H 2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses. © The Royal Society of Chemistry 2011.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.aspen_HK
dc.relation.ispartofChemical Scienceen_HK
dc.subjectCancer cell lines-
dc.subjectCatenin signaling-
dc.subjectComplex 1-
dc.subjectDna binding-
dc.subjectDna micro-array-
dc.titleAn anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signalingen_HK
dc.typeArticleen_HK
dc.identifier.emailSinYin Chui, S: chuissy@hkucc.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authoritySinYin Chui, S=rp00686en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c1sc00203aen_HK
dc.identifier.scopuseid_2-s2.0-81355149545en_HK
dc.identifier.hkuros205322en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81355149545&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1788en_HK
dc.identifier.epage1792en_HK
dc.identifier.isiWOS:000293693700021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLaiFung Chan, S=54395866200en_HK
dc.identifier.scopusauthoridWaiYin Sun, R=54416547900en_HK
dc.identifier.scopusauthoridChoi, MY=36929153100en_HK
dc.identifier.scopusauthoridZeng, Y=7402981405en_HK
dc.identifier.scopusauthoridShek, L=35741917300en_HK
dc.identifier.scopusauthoridSinYin Chui, S=8297453100en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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