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Article: Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment

TitleTherapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment
Authors
Issue Date2011
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2011, v. 47 n. 34, p. 9554-9560 How to Cite?
AbstractGold and its complexes have long been known to display unique biological and medicinal properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the potent anti-cancer activities of diverse classes of gold(I) and gold(III) complexes. Most of the reported anti-cancer active gold complexes are highly cytotoxic and unstable under physiological conditions, which hamper their development to be launched clinically. Several clinical reports showed that lipophilic organic cations are promising anti-cancer drug candidates targeting to mitochondria. Through metal-ligand coordination, gold(I) and gold(III) ions can form stable lipophilic cations containing organic ligands having tunable lipophilicity and diverse functionalities. The present highlight summarizes the recent development of lipophilic gold(III) cations and gold(I) complexes with promising anti-cancer activities.
Persistent Identifierhttp://hdl.handle.net/10722/159401
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChe, CMen_HK
dc.contributor.authorSun, RWYen_HK
dc.date.accessioned2012-08-16T05:49:06Z-
dc.date.available2012-08-16T05:49:06Z-
dc.date.issued2011en_HK
dc.identifier.citationChemical Communications, 2011, v. 47 n. 34, p. 9554-9560en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159401-
dc.description.abstractGold and its complexes have long been known to display unique biological and medicinal properties. Extensive cell-based (in vitro) and animal (in vivo) studies have revealed the potent anti-cancer activities of diverse classes of gold(I) and gold(III) complexes. Most of the reported anti-cancer active gold complexes are highly cytotoxic and unstable under physiological conditions, which hamper their development to be launched clinically. Several clinical reports showed that lipophilic organic cations are promising anti-cancer drug candidates targeting to mitochondria. Through metal-ligand coordination, gold(I) and gold(III) ions can form stable lipophilic cations containing organic ligands having tunable lipophilicity and diverse functionalities. The present highlight summarizes the recent development of lipophilic gold(III) cations and gold(I) complexes with promising anti-cancer activities.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshAntineoplastic Agents - chemistry - pharmacology - therapeutic use-
dc.subject.meshCell Line, Tumor-
dc.subject.meshGold - chemistry-
dc.subject.meshHydrophobic and Hydrophilic Interactions-
dc.subject.meshOrganometallic Compounds - chemistry - pharmacology - therapeutic use-
dc.titleTherapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatmenten_HK
dc.typeArticleen_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c1cc10860cen_HK
dc.identifier.pmid21674082-
dc.identifier.scopuseid_2-s2.0-80051722314en_HK
dc.identifier.hkuros205317en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80051722314&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue34en_HK
dc.identifier.spage9554en_HK
dc.identifier.epage9560en_HK
dc.identifier.eissn1364-548X-
dc.identifier.isiWOS:000293858700001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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