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Article: A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells

TitleA dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells
Authors
Issue Date2012
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp
Citation
Chemical Communications, 2012, v. 48 n. 28, p. 3388-3390 How to Cite?
AbstractThe water-soluble gold(iii) complex [Au III(butyl-CN)biguanide]Cl (butyl-HCN = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations. © 2012 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/159399
ISSN
2015 Impact Factor: 6.567
2015 SCImago Journal Rankings: 2.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, JJen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2012-08-16T05:49:06Z-
dc.date.available2012-08-16T05:49:06Z-
dc.date.issued2012en_HK
dc.identifier.citationChemical Communications, 2012, v. 48 n. 28, p. 3388-3390en_HK
dc.identifier.issn1359-7345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159399-
dc.description.abstractThe water-soluble gold(iii) complex [Au III(butyl-CN)biguanide]Cl (butyl-HCN = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations. © 2012 The Royal Society of Chemistry.en_HK
dc.languageengen_US
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.aspen_HK
dc.relation.ispartofChemical Communicationsen_HK
dc.subject.meshAngiogenesis Inhibitors - pharmacology - toxicityen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Lineen_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshEndoplasmic Reticulum - drug effects - pathologyen_HK
dc.subject.meshEndoplasmic Reticulum Stress - drug effectsen_HK
dc.subject.meshHeLa Cellsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshOrganogold Compounds - pharmacology - toxicityen_HK
dc.subject.meshSolubilityen_HK
dc.subject.meshWater - chemistryen_HK
dc.titleA dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailSun, RWY:rwysun@hku.hken_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c2cc00029fen_HK
dc.identifier.pmid22373586-
dc.identifier.scopuseid_2-s2.0-84863297752en_HK
dc.identifier.hkuros205303en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863297752&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48en_HK
dc.identifier.issue28en_HK
dc.identifier.spage3388en_HK
dc.identifier.epage3390en_HK
dc.identifier.eissn1364-548X-
dc.identifier.isiWOS:000301193100005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhang, JJ=55063903900en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK

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