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Article: Recent advances in bioinorganic chemistry of bismuth
Title | Recent advances in bioinorganic chemistry of bismuth |
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Authors | |
Issue Date | 2012 |
Publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbi |
Citation | Current Opinion in Chemical Biology, 2012, v. 16 n. 1-2, p. 74-83 How to Cite? |
Abstract | Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs. |
Persistent Identifier | http://hdl.handle.net/10722/159376 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.328 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, H | en_HK |
dc.contributor.author | Sun, H | en_HK |
dc.date.accessioned | 2012-08-16T05:48:56Z | - |
dc.date.available | 2012-08-16T05:48:56Z | - |
dc.date.issued | 2012 | en_HK |
dc.identifier.citation | Current Opinion in Chemical Biology, 2012, v. 16 n. 1-2, p. 74-83 | en_HK |
dc.identifier.issn | 1367-5931 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/159376 | - |
dc.description.abstract | Bismuth has been used in medicine for over two centuries for the treatment of various diseases, in particular for gastrointestinal disorders, owing to its antimicrobial activity. Recent structural characterization of bismuth drugs provides an insight into assembly and pharmacokinetic pathway of the drugs. Mining potential protein targets inside the pathogen via metallomic/metalloproteomic approach and further characterization on the interactions of bismuth drugs with these targets laid foundation in understanding the mechanism of action of bismuth drugs. Such studies would be beneficial in rational design of new potential drugs. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cbi | en_HK |
dc.relation.ispartof | Current Opinion in Chemical Biology | en_HK |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in Current Opinion in Chemical Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Current Opinion in Chemical Biology, 2012, v. 16 n. 1-2, p. 74-83. DOI: 10.1016/j.cbpa.2012.01.006 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.mesh | Bismuth - chemistry - metabolism | en_HK |
dc.subject.mesh | Drug Design | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Organic Chemistry Phenomena | en_HK |
dc.subject.mesh | Proteins - chemistry - metabolism | en_HK |
dc.title | Recent advances in bioinorganic chemistry of bismuth | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1367-5931&volume=16&spage=74&epage=83&date=2012&atitle=Recent+advances+in+bioinorganic+chemistry+of+bismuth | en_US |
dc.identifier.email | Li, H: hylichem@hku.hk | en_HK |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Sun, H=rp00777 | en_HK |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.cbpa.2012.01.006 | en_HK |
dc.identifier.pmid | 22322154 | - |
dc.identifier.scopus | eid_2-s2.0-84862813658 | en_HK |
dc.identifier.hkuros | 205075 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84862813658&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 16 | en_HK |
dc.identifier.issue | 1-2 | en_HK |
dc.identifier.spage | 74 | en_HK |
dc.identifier.epage | 83 | en_HK |
dc.identifier.isi | WOS:000303640400011 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Sun, H=7404827446 | en_HK |
dc.identifier.scopusauthorid | Li, H=37063577200 | en_HK |
dc.identifier.citeulike | 10365682 | - |
dc.identifier.issnl | 1367-5931 | - |