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Article: Molecular histology analysis by matrix-assisted laser desorption/ ionization imaging mass spectrometry using gold nanoparticles as matrix

TitleMolecular histology analysis by matrix-assisted laser desorption/ ionization imaging mass spectrometry using gold nanoparticles as matrix
Authors
Issue Date2011
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0951-4198/
Citation
Rapid Communications In Mass Spectrometry, 2011, v. 25 n. 24, p. 3690-3696 How to Cite?
AbstractGold nanoparticles (AuNPs) were applied and optimized as matrix for matrix-assisted laser desorption/ionization mass spectrometry analysis of animal tissues, and enabled histological analysis of animal tissues at molecular level by imaging mass spectrometry (IMS). AuNPs were coated on animal tissue in a solvent-free manner via argon ion sputtering. Metabolites, including neurotransmitters, fatty acids and nucleobases, were directly detected from mouse brain tissue. Based on region-specific chemical profiles, fine histological features of mouse brain tissue and heterogeneous regions of tumor tissue were both revealed. Copyright © 2011 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/159372
ISSN
2015 Impact Factor: 2.226
2015 SCImago Journal Rankings: 0.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, HWen_HK
dc.contributor.authorWong, MYMen_HK
dc.contributor.authorLam, Wen_HK
dc.contributor.authorCheng, YCen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorNg, KMen_HK
dc.date.accessioned2012-08-16T05:48:54Z-
dc.date.available2012-08-16T05:48:54Z-
dc.date.issued2011en_HK
dc.identifier.citationRapid Communications In Mass Spectrometry, 2011, v. 25 n. 24, p. 3690-3696en_HK
dc.identifier.issn0951-4198en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159372-
dc.description.abstractGold nanoparticles (AuNPs) were applied and optimized as matrix for matrix-assisted laser desorption/ionization mass spectrometry analysis of animal tissues, and enabled histological analysis of animal tissues at molecular level by imaging mass spectrometry (IMS). AuNPs were coated on animal tissue in a solvent-free manner via argon ion sputtering. Metabolites, including neurotransmitters, fatty acids and nucleobases, were directly detected from mouse brain tissue. Based on region-specific chemical profiles, fine histological features of mouse brain tissue and heterogeneous regions of tumor tissue were both revealed. Copyright © 2011 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0951-4198/en_HK
dc.relation.ispartofRapid Communications in Mass Spectrometryen_HK
dc.titleMolecular histology analysis by matrix-assisted laser desorption/ ionization imaging mass spectrometry using gold nanoparticles as matrixen_HK
dc.typeArticleen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailNg, KM:kwanmng@hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityNg, KM=rp00766en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/rcm.5281en_HK
dc.identifier.pmid22468326-
dc.identifier.scopuseid_2-s2.0-84857213889en_HK
dc.identifier.hkuros205065en_US
dc.identifier.hkuros201256-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857213889&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue24en_HK
dc.identifier.spage3690en_HK
dc.identifier.epage3696en_HK
dc.identifier.isiWOS:000297930100005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, HW=16231745000en_HK
dc.identifier.scopusauthoridWong, MYM=37076134600en_HK
dc.identifier.scopusauthoridLam, W=7203021943en_HK
dc.identifier.scopusauthoridCheng, YC=36041844200en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridNg, KM=26026091100en_HK

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