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Article: A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells

TitleA synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells
Authors
KeywordsCell membrane permeability
Cell strain HEK293
Chloride channelopathy
Chloride conductance
Chloride transport
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2012, v. 7 n. 4 How to Cite?
AbstractMutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl -) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl - transport through alternative pathways. In this paper, we demonstrate that a small synthetic molecule which forms Cl - channels to mediate Cl - transport across lipid bilayer membranes is capable of restoring Cl - permeability in human CF epithelial cells; as a result, it has the potential to become a lead compound for the treatment of human diseases associated with Cl - channel dysfunction. © 2012 Shen et al.
Persistent Identifierhttp://hdl.handle.net/10722/159320
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShen, Ben_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorWang, Fen_HK
dc.contributor.authorYao, Xen_HK
dc.contributor.authorYang, Den_HK
dc.date.accessioned2012-08-16T05:48:38Z-
dc.date.available2012-08-16T05:48:38Z-
dc.date.issued2012en_HK
dc.identifier.citationPlos One, 2012, v. 7 n. 4en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159320-
dc.description.abstractMutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl -) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl - transport through alternative pathways. In this paper, we demonstrate that a small synthetic molecule which forms Cl - channels to mediate Cl - transport across lipid bilayer membranes is capable of restoring Cl - permeability in human CF epithelial cells; as a result, it has the potential to become a lead compound for the treatment of human diseases associated with Cl - channel dysfunction. © 2012 Shen et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCell membrane permeability-
dc.subjectCell strain HEK293-
dc.subjectChloride channelopathy-
dc.subjectChloride conductance-
dc.subjectChloride transport-
dc.titleA synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, X:xiangli@hku.hken_HK
dc.identifier.emailYang, D:yangdan@hku.hken_HK
dc.identifier.authorityLi, X=rp01562en_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0034694en_HK
dc.identifier.pmid22514656-
dc.identifier.pmcidPMC3326041-
dc.identifier.scopuseid_2-s2.0-84859705589en_HK
dc.identifier.hkuros203828en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859705589&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.isiWOS:000305341600062-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShen, B=8958686600en_HK
dc.identifier.scopusauthoridLi, X=49761544200en_HK
dc.identifier.scopusauthoridWang, F=55183517700en_HK
dc.identifier.scopusauthoridYao, X=7402529434en_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK

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