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Article: Extraordinary metabolic stability of peptides containing α-aminoxy acids

TitleExtraordinary metabolic stability of peptides containing α-aminoxy acids
Authors
Chan, FMa, BYang, ZLin, GYang, D
KeywordsStability
Peptides
Metabolism
Aminoxy acid
Issue Date2012
PublisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/amino_acids
Citation
Amino Acids, 2012, v. 43 n. 1, p. 499-503 How to Cite?
DOI: http://dx.doi.org/10.1007/s00726-011-1095-8
AbstractThe metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides. © 2011 Springer-Verlag.
DescriptionShort communication
Persistent Identifierhttp://hdl.handle.net/10722/159317
ISSN
0939-4451
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.731
ISI Accession Number ID
WOS:000305210800051
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChan, Fen_HK
dc.contributor.authorMa, Ben_HK
dc.contributor.authorYang, Zen_HK
dc.contributor.authorLin, Gen_HK
dc.contributor.authorYang, Den_HK
dc.date.accessioned2012-08-16T05:48:36Z-
dc.date.available2012-08-16T05:48:36Z-
dc.date.issued2012en_HK
dc.identifier.citationAmino Acids, 2012, v. 43 n. 1, p. 499-503en_HK
dc.identifier.issn0939-4451en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159317-
dc.descriptionShort communication-
dc.description.abstractThe metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides. © 2011 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer-Verlag Wien. The Journal's web site is located at http://www.springer.at/amino_acidsen_HK
dc.relation.ispartofAmino Acidsen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectStabilityen_HK
dc.subjectPeptidesen_HK
dc.subjectMetabolismen_HK
dc.subjectAminoxy aciden_HK
dc.subject.meshAmino Acids - chemistry-
dc.subject.meshMicrosomes, Liver - metabolism-
dc.subject.meshPeptides - chemistry - metabolism-
dc.subject.meshProtein Stability-
dc.subject.meshProtein Structure, Secondary-
dc.subject.meshAnimals-
dc.subject.meshRats-
dc.titleExtraordinary metabolic stability of peptides containing α-aminoxy acidsen_HK
dc.typeArticleen_HK
dc.identifier.emailYang, D: yangdan@hku.hken_HK
dc.identifier.authorityYang, D=rp00825en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00726-011-1095-8en_HK
dc.identifier.pmid21964968-
dc.identifier.scopuseid_2-s2.0-84862768277en_HK
dc.identifier.hkuros203808en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862768277&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue1en_HK
dc.identifier.spage499en_HK
dc.identifier.epage503en_HK
dc.identifier.isiWOS:000305210800051-
dc.publisher.placeAustriaen_HK
dc.identifier.scopusauthoridYang, D=7404800756en_HK
dc.identifier.scopusauthoridLin, G=26643369300en_HK
dc.identifier.scopusauthoridYang, ZC=51864670800en_HK
dc.identifier.scopusauthoridMa, B=51864116400en_HK
dc.identifier.scopusauthoridChen, F=7404908085en_HK
dc.identifier.citeulike9848783-
dc.identifier.issnl0939-4451-

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