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Article: Click to join peptides/proteins together

TitleClick to join peptides/proteins together
Authors
Keywordsclick chemistry
cycloaddition
ligation
peptidomimetics
proteins
Issue Date2011
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451
Citation
Chemistry - An Asian Journal, 2011, v. 6 n. 10, p. 2606-2616 How to Cite?
AbstractCopper(I) is able to catalyze Huisgen 1,3-dipolar cycloaddition in a "click" fashion. This copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction presents excellent chemoselectivity and occurs over a wide-range of reaction conditions. It shows tolerance to variation in both pH and solvent polarity, thereby facilitating the ligation of peptides and proteins to produce peptidomimetics and synthetic proteins. In addition, the only product formed is a 1,4-disubstituted-1,2,3-triazole moiety, in many aspects resembling the natural peptide bond, including hydrogen-bonding capability, planarity, distance between the 1 and 4 substituents, and conformational restriction of the peptide backbone; thus the triazole-backbone-modified peptide, in which a triazole replaces the amide bond, may be anticipated to present a secondary structure similar to that of its natural counterpart. This Focus Review describes the scope and applications of copper(I)-catalyzed alkyne-azide cycloaddition in synthetic peptide/protein chemistry. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/159315
ISSN
2015 Impact Factor: 4.592
2015 SCImago Journal Rankings: 1.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.date.accessioned2012-08-16T05:48:36Z-
dc.date.available2012-08-16T05:48:36Z-
dc.date.issued2011en_HK
dc.identifier.citationChemistry - An Asian Journal, 2011, v. 6 n. 10, p. 2606-2616en_HK
dc.identifier.issn1861-4728en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159315-
dc.description.abstractCopper(I) is able to catalyze Huisgen 1,3-dipolar cycloaddition in a "click" fashion. This copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction presents excellent chemoselectivity and occurs over a wide-range of reaction conditions. It shows tolerance to variation in both pH and solvent polarity, thereby facilitating the ligation of peptides and proteins to produce peptidomimetics and synthetic proteins. In addition, the only product formed is a 1,4-disubstituted-1,2,3-triazole moiety, in many aspects resembling the natural peptide bond, including hydrogen-bonding capability, planarity, distance between the 1 and 4 substituents, and conformational restriction of the peptide backbone; thus the triazole-backbone-modified peptide, in which a triazole replaces the amide bond, may be anticipated to present a secondary structure similar to that of its natural counterpart. This Focus Review describes the scope and applications of copper(I)-catalyzed alkyne-azide cycloaddition in synthetic peptide/protein chemistry. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451en_HK
dc.relation.ispartofChemistry - An Asian Journalen_HK
dc.subjectclick chemistryen_HK
dc.subjectcycloadditionen_HK
dc.subjectligationen_HK
dc.subjectpeptidomimeticsen_HK
dc.subjectproteinsen_HK
dc.titleClick to join peptides/proteins togetheren_HK
dc.typeArticleen_HK
dc.identifier.emailLi, X:xuechenl@hku.hken_HK
dc.identifier.authorityLi, X=rp00742en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/asia.201100329en_HK
dc.identifier.pmid22043498-
dc.identifier.scopuseid_2-s2.0-80053550495en_HK
dc.identifier.hkuros203770en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053550495&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2606en_HK
dc.identifier.epage2616en_HK
dc.identifier.eissn1861-471X-
dc.identifier.isiWOS:000296273900004-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLi, X=24168958800en_HK

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