Article: Femtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents

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TitleFemtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents
AuthorsLi, MD1
Li, W1
Ma, J1
Su, T1
Liu, M1
Du, Y2
Phillips, DL1
Issue Date2011
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jpca
CitationJournal Of Physical Chemistry A, 2011, v. 115 n. 49, p. 14168-14174 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp207582w
AbstractHydrogen abstraction reaction of fenofibric acid (FA) in acetonitrile and isopropyl alcohol solvents was studied by femtosecond transient absorption (fs-TA) and nanosecond time-resolved resonance Raman (ns-TR 3) spectroscopy experiments. The singlet excite state ( 1FA) (nπ*) with a maximum transient absorption at 352 nm observed in the fs-TA experiments undergoes efficient intersystem crossing (ISC) to convert into a nπ* triplet state FA ( 3FA) that exhibits two transient absorption bands at 345 and 542 nm. The nπ* 3FA species does not decay obviously within 3000 ps. In the ns-TR 3 experiments, the nπ* 3FA is also observed and completely decays by 120 ns. Compared with the triplet states of benzophenone (BP) and ketoprofen (KP), the nπ* 3FA species seems to have a much higher hydrogen abstraction reactivity so that 3FA decays fast and generates a FA ketyl radical like species. In isopropyl alcohol solvent, the nπ* 3FA exhibits similar reactivity and promptly abstracts a hydrogen from the strong hydrogen donor isopropyl alcohol solvent to generate a ketyl radical intermediate. With the decay of the FA ketyl radical, no light absorption transient (LAT) intermediate is observed in isopropyl alcohol solvent although such a LAT species was observed after similar experiments for BP and KP. Comparison of the ns-TR 3 spectra for the species of interest with results from density functional theory calculations were used to elucidate the identity, structure, properties, and major spectral features of the intermediates observed in the ns-TR 3 spectra. This comparison provides insight into the structure and hydrogen abstraction reactivity of the triplet states of BP derivatives. © 2011 American Chemical Society.
ISSN1089-5639
2011 Impact Factor: 2.946
2011 SCImago Journal Rankings: 0.212
DOIhttp://dx.doi.org/10.1021/jp207582w
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, MD
dc.contributor.authorLi, W
dc.contributor.authorMa, J
dc.contributor.authorSu, T
dc.contributor.authorLiu, M
dc.contributor.authorDu, Y
dc.contributor.authorPhillips, DL
dc.date.accessioned2012-08-16T05:48:27Z
dc.date.available2012-08-16T05:48:27Z
dc.date.issued2011
dc.description.abstractHydrogen abstraction reaction of fenofibric acid (FA) in acetonitrile and isopropyl alcohol solvents was studied by femtosecond transient absorption (fs-TA) and nanosecond time-resolved resonance Raman (ns-TR 3) spectroscopy experiments. The singlet excite state ( 1FA) (nπ*) with a maximum transient absorption at 352 nm observed in the fs-TA experiments undergoes efficient intersystem crossing (ISC) to convert into a nπ* triplet state FA ( 3FA) that exhibits two transient absorption bands at 345 and 542 nm. The nπ* 3FA species does not decay obviously within 3000 ps. In the ns-TR 3 experiments, the nπ* 3FA is also observed and completely decays by 120 ns. Compared with the triplet states of benzophenone (BP) and ketoprofen (KP), the nπ* 3FA species seems to have a much higher hydrogen abstraction reactivity so that 3FA decays fast and generates a FA ketyl radical like species. In isopropyl alcohol solvent, the nπ* 3FA exhibits similar reactivity and promptly abstracts a hydrogen from the strong hydrogen donor isopropyl alcohol solvent to generate a ketyl radical intermediate. With the decay of the FA ketyl radical, no light absorption transient (LAT) intermediate is observed in isopropyl alcohol solvent although such a LAT species was observed after similar experiments for BP and KP. Comparison of the ns-TR 3 spectra for the species of interest with results from density functional theory calculations were used to elucidate the identity, structure, properties, and major spectral features of the intermediates observed in the ns-TR 3 spectra. This comparison provides insight into the structure and hydrogen abstraction reactivity of the triplet states of BP derivatives. © 2011 American Chemical Society.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Physical Chemistry A, 2011, v. 115 n. 49, p. 14168-14174 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp207582w
dc.identifier.doihttp://dx.doi.org/10.1021/jp207582w
dc.identifier.epage14174
dc.identifier.hkuros203387
dc.identifier.issn1089-5639
2011 Impact Factor: 2.946
2011 SCImago Journal Rankings: 0.212
dc.identifier.issue49
dc.identifier.pmid22044318
dc.identifier.scopuseid_2-s2.0-83455195653
dc.identifier.spage14168
dc.identifier.urihttp://hdl.handle.net/10722/159294
dc.identifier.volume115
dc.languageeng
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jpca
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Physical Chemistry A
dc.relation.referencesReferences in Scopus
dc.titleFemtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. China Jiliang University