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Article: Femtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents
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TitleFemtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents
 
AuthorsLi, MD1
Li, W1
Ma, J1
Su, T1
Liu, M1
Du, Y2
Phillips, DL1
 
Issue Date2011
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jpca
 
CitationJournal Of Physical Chemistry A, 2011, v. 115 n. 49, p. 14168-14174 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp207582w
 
AbstractHydrogen abstraction reaction of fenofibric acid (FA) in acetonitrile and isopropyl alcohol solvents was studied by femtosecond transient absorption (fs-TA) and nanosecond time-resolved resonance Raman (ns-TR 3) spectroscopy experiments. The singlet excite state ( 1FA) (nπ*) with a maximum transient absorption at 352 nm observed in the fs-TA experiments undergoes efficient intersystem crossing (ISC) to convert into a nπ* triplet state FA ( 3FA) that exhibits two transient absorption bands at 345 and 542 nm. The nπ* 3FA species does not decay obviously within 3000 ps. In the ns-TR 3 experiments, the nπ* 3FA is also observed and completely decays by 120 ns. Compared with the triplet states of benzophenone (BP) and ketoprofen (KP), the nπ* 3FA species seems to have a much higher hydrogen abstraction reactivity so that 3FA decays fast and generates a FA ketyl radical like species. In isopropyl alcohol solvent, the nπ* 3FA exhibits similar reactivity and promptly abstracts a hydrogen from the strong hydrogen donor isopropyl alcohol solvent to generate a ketyl radical intermediate. With the decay of the FA ketyl radical, no light absorption transient (LAT) intermediate is observed in isopropyl alcohol solvent although such a LAT species was observed after similar experiments for BP and KP. Comparison of the ns-TR 3 spectra for the species of interest with results from density functional theory calculations were used to elucidate the identity, structure, properties, and major spectral features of the intermediates observed in the ns-TR 3 spectra. This comparison provides insight into the structure and hydrogen abstraction reactivity of the triplet states of BP derivatives. © 2011 American Chemical Society.
 
ISSN1089-5639
2013 Impact Factor: 2.775
 
DOIhttp://dx.doi.org/10.1021/jp207582w
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, MD
 
dc.contributor.authorLi, W
 
dc.contributor.authorMa, J
 
dc.contributor.authorSu, T
 
dc.contributor.authorLiu, M
 
dc.contributor.authorDu, Y
 
dc.contributor.authorPhillips, DL
 
dc.date.accessioned2012-08-16T05:48:27Z
 
dc.date.available2012-08-16T05:48:27Z
 
dc.date.issued2011
 
dc.description.abstractHydrogen abstraction reaction of fenofibric acid (FA) in acetonitrile and isopropyl alcohol solvents was studied by femtosecond transient absorption (fs-TA) and nanosecond time-resolved resonance Raman (ns-TR 3) spectroscopy experiments. The singlet excite state ( 1FA) (nπ*) with a maximum transient absorption at 352 nm observed in the fs-TA experiments undergoes efficient intersystem crossing (ISC) to convert into a nπ* triplet state FA ( 3FA) that exhibits two transient absorption bands at 345 and 542 nm. The nπ* 3FA species does not decay obviously within 3000 ps. In the ns-TR 3 experiments, the nπ* 3FA is also observed and completely decays by 120 ns. Compared with the triplet states of benzophenone (BP) and ketoprofen (KP), the nπ* 3FA species seems to have a much higher hydrogen abstraction reactivity so that 3FA decays fast and generates a FA ketyl radical like species. In isopropyl alcohol solvent, the nπ* 3FA exhibits similar reactivity and promptly abstracts a hydrogen from the strong hydrogen donor isopropyl alcohol solvent to generate a ketyl radical intermediate. With the decay of the FA ketyl radical, no light absorption transient (LAT) intermediate is observed in isopropyl alcohol solvent although such a LAT species was observed after similar experiments for BP and KP. Comparison of the ns-TR 3 spectra for the species of interest with results from density functional theory calculations were used to elucidate the identity, structure, properties, and major spectral features of the intermediates observed in the ns-TR 3 spectra. This comparison provides insight into the structure and hydrogen abstraction reactivity of the triplet states of BP derivatives. © 2011 American Chemical Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Physical Chemistry A, 2011, v. 115 n. 49, p. 14168-14174 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jp207582w
 
dc.identifier.doihttp://dx.doi.org/10.1021/jp207582w
 
dc.identifier.epage14174
 
dc.identifier.hkuros203387
 
dc.identifier.issn1089-5639
2013 Impact Factor: 2.775
 
dc.identifier.issue49
 
dc.identifier.pmid22044318
 
dc.identifier.scopuseid_2-s2.0-83455195653
 
dc.identifier.spage14168
 
dc.identifier.urihttp://hdl.handle.net/10722/159294
 
dc.identifier.volume115
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jpca
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Physical Chemistry A
 
dc.relation.referencesReferences in Scopus
 
dc.titleFemtosecond transient absorption, nanosecond time-resolved resonance Raman, and density functional theory study of fenofibric acid in acetonitrile and isopropyl alcohol solvents
 
dc.typeArticle
 
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<description.abstract>Hydrogen abstraction reaction of fenofibric acid (FA) in acetonitrile and isopropyl alcohol solvents was studied by femtosecond transient absorption (fs-TA) and nanosecond time-resolved resonance Raman (ns-TR 3) spectroscopy experiments. The singlet excite state ( 1FA) (n&#960;*) with a maximum transient absorption at 352 nm observed in the fs-TA experiments undergoes efficient intersystem crossing (ISC) to convert into a n&#960;* triplet state FA ( 3FA) that exhibits two transient absorption bands at 345 and 542 nm. The n&#960;* 3FA species does not decay obviously within 3000 ps. In the ns-TR 3 experiments, the n&#960;* 3FA is also observed and completely decays by 120 ns. Compared with the triplet states of benzophenone (BP) and ketoprofen (KP), the n&#960;* 3FA species seems to have a much higher hydrogen abstraction reactivity so that 3FA decays fast and generates a FA ketyl radical like species. In isopropyl alcohol solvent, the n&#960;* 3FA exhibits similar reactivity and promptly abstracts a hydrogen from the strong hydrogen donor isopropyl alcohol solvent to generate a ketyl radical intermediate. With the decay of the FA ketyl radical, no light absorption transient (LAT) intermediate is observed in isopropyl alcohol solvent although such a LAT species was observed after similar experiments for BP and KP. Comparison of the ns-TR 3 spectra for the species of interest with results from density functional theory calculations were used to elucidate the identity, structure, properties, and major spectral features of the intermediates observed in the ns-TR 3 spectra. This comparison provides insight into the structure and hydrogen abstraction reactivity of the triplet states of BP derivatives. &#169; 2011 American Chemical Society.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. China Jiliang University